CA3227486A1 - Domaines et echafaudages vnar desimmunises - Google Patents

Domaines et echafaudages vnar desimmunises Download PDF

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Publication number
CA3227486A1
CA3227486A1 CA3227486A CA3227486A CA3227486A1 CA 3227486 A1 CA3227486 A1 CA 3227486A1 CA 3227486 A CA3227486 A CA 3227486A CA 3227486 A CA3227486 A CA 3227486A CA 3227486 A1 CA3227486 A1 CA 3227486A1
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CA
Canada
Prior art keywords
amino acid
vnar
region
seq
domain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3227486A
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English (en)
Inventor
Pawel STOCKI
Julia Lynn Rutkowski
Mykhaylo DEMYDCHUK
Shu-Fen COKER
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Ossianix Inc
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Individual
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Priority claimed from PCT/US2022/040616 external-priority patent/WO2023023166A1/fr
Publication of CA3227486A1 publication Critical patent/CA3227486A1/fr
Pending legal-status Critical Current

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La présente invention concerne des échafaudages VNAR désimmunisés, des procédés de fabrication des échafaudages et leur utilisation en tant que structures, et des domaines VNAR comprenant ces échafaudages, en particulier des domaines VNAR thérapeutiques à un antigène cible d'intérêt, comprenant, par exemple, des domaines VNAR à haute affinité qui présentent une réaction croisée avec les récepteurs de la transferrine (TfR) de primate ainsi que d'autres domaines VNAR susceptibles de transporter une charge thérapeutique ou diagnostique à travers la barrière hémato-encéphalique.
CA3227486A 2021-08-17 2022-08-17 Domaines et echafaudages vnar desimmunises Pending CA3227486A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163234210P 2021-08-17 2021-08-17
US63/234,210 2021-08-17
US202163277590P 2021-11-09 2021-11-09
US63/277,590 2021-11-09
PCT/US2022/040616 WO2023023166A1 (fr) 2021-08-17 2022-08-17 Domaines et échafaudages vnar désimmunisés

Publications (1)

Publication Number Publication Date
CA3227486A1 true CA3227486A1 (fr) 2023-02-23

Family

ID=89722117

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3227486A Pending CA3227486A1 (fr) 2021-08-17 2022-08-17 Domaines et echafaudages vnar desimmunises

Country Status (1)

Country Link
CA (1) CA3227486A1 (fr)

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