CA3221581A1 - Proteines actrii et leurs utilisations - Google Patents

Proteines actrii et leurs utilisations Download PDF

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Publication number
CA3221581A1
CA3221581A1 CA3221581A CA3221581A CA3221581A1 CA 3221581 A1 CA3221581 A1 CA 3221581A1 CA 3221581 A CA3221581 A CA 3221581A CA 3221581 A CA3221581 A CA 3221581A CA 3221581 A1 CA3221581 A1 CA 3221581A1
Authority
CA
Canada
Prior art keywords
patient
seq
pulmonary
acid sequence
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3221581A
Other languages
English (en)
Inventor
Gang Li
Patrick Andre
Ravindra Kumar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Acceleron Pharma Inc
Original Assignee
Acceleron Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acceleron Pharma Inc filed Critical Acceleron Pharma Inc
Publication of CA3221581A1 publication Critical patent/CA3221581A1/fr
Pending legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1796Receptors; Cell surface antigens; Cell surface determinants for hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Selon certains aspects, l'invention concerne des compositions et des méthodes comprenant des polypeptides ActRII pour traiter, prévenir ou réduire la vitesse de progression et/ou la gravité de l'hypertension pulmonaire associée à une maladie pulmonaire (par exemple, l'hypertension pulmonaire associée à une maladie pulmonaire obstructive chronique (COPD), à une maladie pulmonaire interstitielle (ILD), ou à une fibrose et emphysème pulmonaires combinées (CPFE)), en particulier le traitement, la prévention ou la réduction de la vitesse de progression et/ou de la gravité d'une ou plusieurs hypertensions pulmonaires associées à des complications associées à une maladie pulmonaire (par exemple, l'hypertension pulmonaire associée à une maladie pulmonaire obstructive chronique (COPD), à une maladie pulmonaire interstitielle (ILD), ou à une fibrose et emphysème pulmonaires combinées (CPFE)).
CA3221581A 2021-06-11 2022-06-10 Proteines actrii et leurs utilisations Pending CA3221581A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163209871P 2021-06-11 2021-06-11
US63/209,871 2021-06-11
PCT/US2022/033007 WO2022261436A2 (fr) 2021-06-11 2022-06-10 Protéines actrii et leurs utilisations

Publications (1)

Publication Number Publication Date
CA3221581A1 true CA3221581A1 (fr) 2022-12-15

Family

ID=84426426

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3221581A Pending CA3221581A1 (fr) 2021-06-11 2022-06-10 Proteines actrii et leurs utilisations

Country Status (15)

Country Link
US (1) US20240277806A1 (fr)
EP (1) EP4351626A2 (fr)
JP (1) JP2024521575A (fr)
KR (1) KR20240035445A (fr)
CN (1) CN117794562A (fr)
AU (1) AU2022289885A1 (fr)
CA (1) CA3221581A1 (fr)
CL (1) CL2023003659A1 (fr)
CO (1) CO2024000079A2 (fr)
CR (1) CR20240013A (fr)
DO (1) DOP2023000269A (fr)
EC (1) ECSP24002381A (fr)
IL (1) IL309100A (fr)
MX (1) MX2023014761A (fr)
WO (1) WO2022261436A2 (fr)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109153713B (zh) * 2016-03-10 2022-12-27 艾科赛扬制药股份有限公司 活化素2型受体结合蛋白及其用途
DK3496739T3 (da) * 2016-07-15 2021-05-10 Acceleron Pharma Inc Sammensætninger omfattende actriia-polypeptider til brug i behandlingen af pulmonal hypertension
US20240226235A1 (en) * 2019-11-05 2024-07-11 Acceleron Pharma Inc. Treatments for systemic sclerosis

Also Published As

Publication number Publication date
DOP2023000269A (es) 2024-04-30
IL309100A (en) 2024-02-01
CN117794562A (zh) 2024-03-29
CO2024000079A2 (es) 2024-01-25
US20240277806A1 (en) 2024-08-22
CL2023003659A1 (es) 2024-06-28
KR20240035445A (ko) 2024-03-15
WO2022261436A2 (fr) 2022-12-15
EP4351626A2 (fr) 2024-04-17
JP2024521575A (ja) 2024-06-03
ECSP24002381A (es) 2024-02-29
AU2022289885A1 (en) 2024-01-18
CR20240013A (es) 2024-04-01
MX2023014761A (es) 2024-01-19
WO2022261436A3 (fr) 2023-01-19

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