CA3186564A1 - Method for treating graft versus host disease caused by hematopoietic stem cell transplantation - Google Patents
Method for treating graft versus host disease caused by hematopoietic stem cell transplantationInfo
- Publication number
- CA3186564A1 CA3186564A1 CA3186564A CA3186564A CA3186564A1 CA 3186564 A1 CA3186564 A1 CA 3186564A1 CA 3186564 A CA3186564 A CA 3186564A CA 3186564 A CA3186564 A CA 3186564A CA 3186564 A1 CA3186564 A1 CA 3186564A1
- Authority
- CA
- Canada
- Prior art keywords
- days
- compound
- gekg
- group
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010713637.0 | 2020-07-22 | ||
CN202010713637 | 2020-07-22 | ||
PCT/CN2021/107575 WO2022017412A1 (zh) | 2020-07-22 | 2021-07-21 | 治疗造血干细胞移植后的移植物抗宿主病的方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA3186564A1 true CA3186564A1 (en) | 2022-01-27 |
Family
ID=79728482
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA3186564A Pending CA3186564A1 (en) | 2020-07-22 | 2021-07-21 | Method for treating graft versus host disease caused by hematopoietic stem cell transplantation |
Country Status (11)
Country | Link |
---|---|
US (1) | US20230285393A1 (pt) |
EP (1) | EP4186508A1 (pt) |
JP (1) | JP2023535035A (pt) |
KR (1) | KR20230043891A (pt) |
CN (1) | CN116322670A (pt) |
AU (1) | AU2021313124A1 (pt) |
BR (1) | BR112023001049A2 (pt) |
CA (1) | CA3186564A1 (pt) |
IL (1) | IL299985A (pt) |
TW (2) | TW202216691A (pt) |
WO (1) | WO2022017412A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4393917A1 (en) * | 2021-09-18 | 2024-07-03 | Beijing Tide Pharmaceutical Co., Ltd. | Solid form of rho-associated protein kinase inhibitor or solvate thereof, preparation method and use thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2010222848A1 (en) * | 2009-03-09 | 2011-10-20 | Surface Logix, Inc. | Rho kinase inhibitors |
EP2903618B1 (en) * | 2012-10-05 | 2022-06-01 | Kadmon Corporation, LLC | Rho kinase inhibitors |
WO2018039539A1 (en) * | 2016-08-26 | 2018-03-01 | Lycera Corporation | Indazolyl-l,2,4-thiadiazolamines and related compounds for inhibition of rho-associated protein kinase and the treatment of disease |
ES2969536T3 (es) | 2017-06-30 | 2024-05-21 | Beijing Tide Pharmaceutical Co Ltd | Inhibidor de la proteína cinasa asociada a rho, composición farmacéutica que lo comprende, y su método de preparación y uso |
KR102469161B1 (ko) * | 2017-06-30 | 2022-11-23 | 베이징 타이드 파마슈티컬 코퍼레이션 리미티드 | Rho-관련 단백질 키나아제 억제제, Rho-관련 단백질 키나아제 억제제를 함유하는 약학 조성물, 제조 방법 및 약학 조성물의 용도 |
WO2019000682A1 (zh) * | 2017-06-30 | 2019-01-03 | 北京泰德制药股份有限公司 | Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途 |
-
2021
- 2021-07-21 KR KR1020237005450A patent/KR20230043891A/ko unknown
- 2021-07-21 TW TW110126814A patent/TW202216691A/zh unknown
- 2021-07-21 CN CN202180059344.8A patent/CN116322670A/zh active Pending
- 2021-07-21 EP EP21845732.3A patent/EP4186508A1/en active Pending
- 2021-07-21 BR BR112023001049A patent/BR112023001049A2/pt unknown
- 2021-07-21 WO PCT/CN2021/107575 patent/WO2022017412A1/zh unknown
- 2021-07-21 JP JP2023504356A patent/JP2023535035A/ja active Pending
- 2021-07-21 CA CA3186564A patent/CA3186564A1/en active Pending
- 2021-07-21 US US18/017,198 patent/US20230285393A1/en active Pending
- 2021-07-21 AU AU2021313124A patent/AU2021313124A1/en active Pending
- 2021-07-21 TW TW112113471A patent/TW202327609A/zh unknown
- 2021-07-21 IL IL299985A patent/IL299985A/en unknown
Also Published As
Publication number | Publication date |
---|---|
TW202327609A (zh) | 2023-07-16 |
EP4186508A1 (en) | 2023-05-31 |
AU2021313124A1 (en) | 2023-03-09 |
IL299985A (en) | 2023-03-01 |
TW202216691A (zh) | 2022-05-01 |
JP2023535035A (ja) | 2023-08-15 |
WO2022017412A1 (zh) | 2022-01-27 |
CN116322670A (zh) | 2023-06-23 |
KR20230043891A (ko) | 2023-03-31 |
BR112023001049A2 (pt) | 2023-03-07 |
US20230285393A1 (en) | 2023-09-14 |
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