CA3184819A1 - Chimeres de proteine orthogonale polyfonctionnelle - Google Patents
Chimeres de proteine orthogonale polyfonctionnelleInfo
- Publication number
- CA3184819A1 CA3184819A1 CA3184819A CA3184819A CA3184819A1 CA 3184819 A1 CA3184819 A1 CA 3184819A1 CA 3184819 A CA3184819 A CA 3184819A CA 3184819 A CA3184819 A CA 3184819A CA 3184819 A1 CA3184819 A1 CA 3184819A1
- Authority
- CA
- Canada
- Prior art keywords
- cells
- polypeptide
- domain
- protein
- engineered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Abstract
L'invention divulgue des protéines hétérodimères ou hétérotrimères modifiées qui utilisent un domaine polypeptidique d'origine non naturelle comprenant de 1 à 5 hélices alpha reliées par des lieurs d'acide aminé et un domaine de charnière IgG2 soit seul soit conjointement avec un domaine de Fc d'IgG2. Les protéines hétérodimères et hétérotrimères peuvent en outre comprendre un fragment de liaison à l'antigène qui se lie à un antigène de surface cellulaire spécifique à une lignée, un polypeptide qui se lie à une molécule exprimée sur une cellule immunitaire (par exemple, une cellule tueuse naturelle) et/ou un polypeptide qui se lie à une molécule exprimée sur un autre type de cellule immunitaire (par exemple, des lymphocytes T). L'invention divulgue également des acides nucléiques codant pour les protéines, des vecteurs comprenant les acides nucléiques, des compositions et des méthodes de traitement.
Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63/047,938 | 2020-07-03 | ||
| US202063050346P | 2020-07-10 | 2020-07-10 | |
| US63/050,346 | 2020-07-10 | ||
| US202063075388P | 2020-09-08 | 2020-09-08 | |
| US63/075,388 | 2020-09-08 | ||
| US202163145083P | 2021-02-03 | 2021-02-03 | |
| US63/145,083 | 2021-02-03 | ||
| US202163189412P | 2021-05-17 | 2021-05-17 | |
| US63/189,412 | 2021-05-17 | ||
| PCT/US2021/040538 WO2022006564A1 (fr) | 2020-07-03 | 2021-07-06 | Chimères de protéine orthogonale polyfonctionnelle |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3184819A1 true CA3184819A1 (fr) | 2022-01-06 |
Family
ID=85380732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3184819A Pending CA3184819A1 (fr) | 2020-07-03 | 2021-07-06 | Chimeres de proteine orthogonale polyfonctionnelle |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA3184819A1 (fr) |
-
2021
- 2021-07-06 CA CA3184819A patent/CA3184819A1/fr active Pending
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