CA3168146A1 - Therapeutic tyrosine kinase inhibitors for relapsing multiple sclerosis (rms) - Google Patents

Therapeutic tyrosine kinase inhibitors for relapsing multiple sclerosis (rms)

Info

Publication number
CA3168146A1
CA3168146A1 CA3168146A CA3168146A CA3168146A1 CA 3168146 A1 CA3168146 A1 CA 3168146A1 CA 3168146 A CA3168146 A CA 3168146A CA 3168146 A CA3168146 A CA 3168146A CA 3168146 A1 CA3168146 A1 CA 3168146A1
Authority
CA
Canada
Prior art keywords
tyrosine kinase
therapeutic
multiple sclerosis
rms
kinase inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3168146A
Other languages
English (en)
French (fr)
Inventor
Meehyung CHO
Timothy J. Turner
Erik Wallstroem
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genzyme Corp
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of CA3168146A1 publication Critical patent/CA3168146A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA3168146A 2020-01-20 2021-01-19 Therapeutic tyrosine kinase inhibitors for relapsing multiple sclerosis (rms) Pending CA3168146A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202062963238P 2020-01-20 2020-01-20
US62/963,238 2020-01-20
US202062970502P 2020-02-05 2020-02-05
US62/970,502 2020-02-05
US202063013895P 2020-04-22 2020-04-22
US63/013,895 2020-04-22
PCT/US2021/013883 WO2021150476A1 (en) 2020-01-20 2021-01-19 Therapeutic tyrosine kinase inhibitors for relapsing multiple sclerosis (rms)

Publications (1)

Publication Number Publication Date
CA3168146A1 true CA3168146A1 (en) 2021-07-29

Family

ID=74626161

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3168146A Pending CA3168146A1 (en) 2020-01-20 2021-01-19 Therapeutic tyrosine kinase inhibitors for relapsing multiple sclerosis (rms)

Country Status (12)

Country Link
US (2) US11969418B2 (cg-RX-API-DMAC10.html)
EP (1) EP4093397A1 (cg-RX-API-DMAC10.html)
JP (2) JP2023510604A (cg-RX-API-DMAC10.html)
KR (1) KR102971371B1 (cg-RX-API-DMAC10.html)
CN (1) CN115348862A (cg-RX-API-DMAC10.html)
AU (1) AU2021209608B2 (cg-RX-API-DMAC10.html)
BR (1) BR112022014058A2 (cg-RX-API-DMAC10.html)
CA (1) CA3168146A1 (cg-RX-API-DMAC10.html)
IL (1) IL294560A (cg-RX-API-DMAC10.html)
MX (1) MX2022008875A (cg-RX-API-DMAC10.html)
TW (1) TWI883107B (cg-RX-API-DMAC10.html)
WO (1) WO2021150476A1 (cg-RX-API-DMAC10.html)

Families Citing this family (12)

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CA3168146A1 (en) * 2020-01-20 2021-07-29 Genzyme Corporation Therapeutic tyrosine kinase inhibitors for relapsing multiple sclerosis (rms)
CA3201936A1 (en) * 2020-12-10 2022-06-16 Minhua Chen Crystal form of tolebrutinib and preparation method thereof
IL303834A (en) 2020-12-23 2023-08-01 Genzyme Corp 4-amino-3-(4-phenoxyphenyl)-1,3-dihydro-2H-imidazo[4,5-C]pyridin-2-one derivatives and their salts
CN117295735B (zh) * 2021-04-23 2026-05-12 杭州领业医药科技有限公司 Tolebrutinib晶型、无定型及其制备方法和用途
CN117412749A (zh) * 2021-05-21 2024-01-16 杭州领业医药科技有限公司 Tolebrutinib盐及其晶型、其制备方法、其药物组合物和用途
WO2022257845A1 (zh) * 2021-06-11 2022-12-15 苏州科睿思制药有限公司 Tolebrutinib的晶型及其制备方法和用途
WO2023280132A1 (zh) * 2021-07-06 2023-01-12 苏州晶云药物科技股份有限公司 氧代二氢咪唑并吡啶类化合物的晶型及其制备方法
CA3260159A1 (en) * 2022-06-30 2024-01-04 Principia Biopharma Inc. Therapeutic Tyrosine Kinase Inhibitors for the Treatment of Multiple Sclerosis and Myasthenia Gravis
US20240173313A1 (en) * 2022-10-11 2024-05-30 Genzyme Corporation Therapeutic tyrosine kinase inhibitors for multiple sclerosis
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WO2025264860A2 (en) 2024-06-18 2025-12-26 Yale University Methods of treating post-covid airway disease

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Also Published As

Publication number Publication date
KR102971371B1 (ko) 2026-06-02
AU2021209608A1 (en) 2022-09-15
JP2026001038A (ja) 2026-01-06
MX2022008875A (es) 2022-08-11
IL294560A (en) 2022-09-01
WO2021150476A1 (en) 2021-07-29
JP2023510604A (ja) 2023-03-14
US11969418B2 (en) 2024-04-30
EP4093397A1 (en) 2022-11-30
US20210244720A1 (en) 2021-08-12
KR20220130179A (ko) 2022-09-26
CN115348862A (zh) 2022-11-15
TW202140002A (zh) 2021-11-01
US12636280B2 (en) 2026-05-26
BR112022014058A2 (pt) 2022-09-13
US20240366585A1 (en) 2024-11-07
AU2021209608B2 (en) 2026-06-04
TWI883107B (zh) 2025-05-11

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