CA3163199A1 - Biomarqueur du cancer des ovaires et ses procedes d~utilisation - Google Patents
Biomarqueur du cancer des ovaires et ses procedes d~utilisation Download PDFInfo
- Publication number
- CA3163199A1 CA3163199A1 CA3163199A CA3163199A CA3163199A1 CA 3163199 A1 CA3163199 A1 CA 3163199A1 CA 3163199 A CA3163199 A CA 3163199A CA 3163199 A CA3163199 A CA 3163199A CA 3163199 A1 CA3163199 A1 CA 3163199A1
- Authority
- CA
- Canada
- Prior art keywords
- arresten
- ovarian cancer
- subject
- antibody
- expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010033128 Ovarian cancer Diseases 0.000 title claims abstract description 338
- 206010061535 Ovarian neoplasm Diseases 0.000 title claims abstract description 327
- 238000000034 method Methods 0.000 title claims abstract description 186
- 239000000107 tumor biomarker Substances 0.000 title description 11
- 229960003738 meticrane Drugs 0.000 claims abstract description 334
- 101800001248 Arresten Proteins 0.000 claims abstract description 326
- 102400000729 Arresten Human genes 0.000 claims abstract description 326
- FNQQBFNIYODEMB-UHFFFAOYSA-N Meticrane Chemical compound C1CCS(=O)(=O)C2=C1C=C(C)C(S(N)(=O)=O)=C2 FNQQBFNIYODEMB-UHFFFAOYSA-N 0.000 claims abstract description 325
- 238000011282 treatment Methods 0.000 claims abstract description 39
- 230000014509 gene expression Effects 0.000 claims description 140
- 239000000523 sample Substances 0.000 claims description 131
- 101000623901 Homo sapiens Mucin-16 Proteins 0.000 claims description 94
- 238000001514 detection method Methods 0.000 claims description 66
- 230000035945 sensitivity Effects 0.000 claims description 49
- 102000004190 Enzymes Human genes 0.000 claims description 36
- 108090000790 Enzymes Proteins 0.000 claims description 36
- 239000012472 biological sample Substances 0.000 claims description 33
- 101500026840 Homo sapiens Arresten Proteins 0.000 claims description 30
- 108090000623 proteins and genes Proteins 0.000 claims description 29
- 210000002966 serum Anatomy 0.000 claims description 29
- 239000003153 chemical reaction reagent Substances 0.000 claims description 28
- 230000027455 binding Effects 0.000 claims description 25
- 239000007787 solid Substances 0.000 claims description 25
- 102000004169 proteins and genes Human genes 0.000 claims description 23
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 20
- 102000055862 human MUC16 Human genes 0.000 claims description 18
- 239000011159 matrix material Substances 0.000 claims description 14
- 230000008569 process Effects 0.000 claims description 14
- 239000000758 substrate Substances 0.000 claims description 14
- 238000002512 chemotherapy Methods 0.000 claims description 12
- 108010090804 Streptavidin Proteins 0.000 claims description 11
- 229960002685 biotin Drugs 0.000 claims description 10
- 235000020958 biotin Nutrition 0.000 claims description 10
- 239000011616 biotin Substances 0.000 claims description 10
- 238000009007 Diagnostic Kit Methods 0.000 claims description 9
- 238000001959 radiotherapy Methods 0.000 claims description 8
- 108090001008 Avidin Proteins 0.000 claims description 7
- 238000010166 immunofluorescence Methods 0.000 claims description 6
- 238000002372 labelling Methods 0.000 claims description 6
- 230000013595 glycosylation Effects 0.000 claims description 5
- 238000006206 glycosylation reaction Methods 0.000 claims description 5
- 238000005415 bioluminescence Methods 0.000 claims description 4
- 230000029918 bioluminescence Effects 0.000 claims description 4
- 238000004737 colorimetric analysis Methods 0.000 claims description 4
- 230000022811 deglycosylation Effects 0.000 claims description 4
- 238000005259 measurement Methods 0.000 claims description 4
- 230000003100 immobilizing effect Effects 0.000 claims description 3
- 239000000090 biomarker Substances 0.000 abstract description 80
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 43
- 201000010099 disease Diseases 0.000 abstract description 41
- 239000003795 chemical substances by application Substances 0.000 abstract description 28
- 238000012544 monitoring process Methods 0.000 abstract description 7
- 230000004044 response Effects 0.000 abstract description 7
- 239000000439 tumor marker Substances 0.000 abstract description 2
- 206010028980 Neoplasm Diseases 0.000 description 127
- 201000011510 cancer Diseases 0.000 description 79
- 102100023123 Mucin-16 Human genes 0.000 description 76
- 238000012360 testing method Methods 0.000 description 49
- 101000955067 Homo sapiens WAP four-disulfide core domain protein 2 Proteins 0.000 description 41
- 102100038965 WAP four-disulfide core domain protein 2 Human genes 0.000 description 41
- 238000002965 ELISA Methods 0.000 description 39
- 210000002381 plasma Anatomy 0.000 description 34
- 210000002700 urine Anatomy 0.000 description 33
- 238000003745 diagnosis Methods 0.000 description 31
- 229940088598 enzyme Drugs 0.000 description 29
- 238000004393 prognosis Methods 0.000 description 28
- 210000004027 cell Anatomy 0.000 description 26
- 238000012216 screening Methods 0.000 description 26
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 description 25
- 238000003556 assay Methods 0.000 description 24
- 238000002560 therapeutic procedure Methods 0.000 description 24
- 230000004083 survival effect Effects 0.000 description 23
- 238000003018 immunoassay Methods 0.000 description 19
- 101000721661 Homo sapiens Cellular tumor antigen p53 Proteins 0.000 description 18
- 208000007571 Ovarian Epithelial Carcinoma Diseases 0.000 description 17
- 210000001519 tissue Anatomy 0.000 description 17
- 239000003550 marker Substances 0.000 description 15
- 230000002611 ovarian Effects 0.000 description 15
- 230000036470 plasma concentration Effects 0.000 description 14
- 238000003118 sandwich ELISA Methods 0.000 description 14
- 239000002250 absorbent Substances 0.000 description 13
- 230000002745 absorbent Effects 0.000 description 13
- 238000002405 diagnostic procedure Methods 0.000 description 13
- 210000004369 blood Anatomy 0.000 description 12
- 239000008280 blood Substances 0.000 description 12
- 230000001965 increasing effect Effects 0.000 description 12
- 230000035772 mutation Effects 0.000 description 12
- 238000004458 analytical method Methods 0.000 description 11
- 238000009535 clinical urine test Methods 0.000 description 11
- 239000000463 material Substances 0.000 description 11
- 230000007423 decrease Effects 0.000 description 10
- 239000012634 fragment Substances 0.000 description 10
- 239000000427 antigen Substances 0.000 description 9
- 108091007433 antigens Proteins 0.000 description 9
- 102000036639 antigens Human genes 0.000 description 9
- 230000003211 malignant effect Effects 0.000 description 9
- 206010034260 pelvic mass Diseases 0.000 description 9
- 208000024891 symptom Diseases 0.000 description 9
- 208000035269 cancer or benign tumor Diseases 0.000 description 8
- 239000003085 diluting agent Substances 0.000 description 8
- 238000003364 immunohistochemistry Methods 0.000 description 8
- 230000036210 malignancy Effects 0.000 description 8
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 8
- 239000011534 wash buffer Substances 0.000 description 8
- 206010027476 Metastases Diseases 0.000 description 7
- 108010078814 Tumor Suppressor Protein p53 Proteins 0.000 description 7
- 108010035532 Collagen Proteins 0.000 description 6
- 102000008186 Collagen Human genes 0.000 description 6
- 229920001436 collagen Polymers 0.000 description 6
- 238000011334 debulking surgery Methods 0.000 description 6
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 6
- 230000002349 favourable effect Effects 0.000 description 6
- 210000004185 liver Anatomy 0.000 description 6
- 230000009401 metastasis Effects 0.000 description 6
- 239000002953 phosphate buffered saline Substances 0.000 description 6
- 238000010200 validation analysis Methods 0.000 description 6
- 238000001262 western blot Methods 0.000 description 6
- 201000009030 Carcinoma Diseases 0.000 description 5
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 5
- 208000009956 adenocarcinoma Diseases 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 208000037828 epithelial carcinoma Diseases 0.000 description 5
- 238000000684 flow cytometry Methods 0.000 description 5
- 230000001976 improved effect Effects 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 238000010197 meta-analysis Methods 0.000 description 5
- 238000010837 poor prognosis Methods 0.000 description 5
- 208000004548 serous cystadenocarcinoma Diseases 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 238000001356 surgical procedure Methods 0.000 description 5
- 238000002604 ultrasonography Methods 0.000 description 5
- 208000026310 Breast neoplasm Diseases 0.000 description 4
- 208000016908 Female Genital disease Diseases 0.000 description 4
- 208000029082 Pelvic Inflammatory Disease Diseases 0.000 description 4
- 210000001124 body fluid Anatomy 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 230000034994 death Effects 0.000 description 4
- 231100000517 death Toxicity 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 208000019622 heart disease Diseases 0.000 description 4
- 238000001114 immunoprecipitation Methods 0.000 description 4
- 208000027866 inflammatory disease Diseases 0.000 description 4
- 230000003993 interaction Effects 0.000 description 4
- 208000017169 kidney disease Diseases 0.000 description 4
- 208000019423 liver disease Diseases 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 230000002018 overexpression Effects 0.000 description 4
- 230000001575 pathological effect Effects 0.000 description 4
- 230000037361 pathway Effects 0.000 description 4
- 229910052697 platinum Inorganic materials 0.000 description 4
- 230000005855 radiation Effects 0.000 description 4
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 3
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 3
- 101100423701 Arabidopsis thaliana OVA1 gene Proteins 0.000 description 3
- 108700010154 BRCA2 Genes Proteins 0.000 description 3
- 101150008921 Brca2 gene Proteins 0.000 description 3
- 206010006187 Breast cancer Diseases 0.000 description 3
- 208000020446 Cardiac disease Diseases 0.000 description 3
- 102100024458 Cyclin-dependent kinase inhibitor 2A Human genes 0.000 description 3
- 206010014759 Endometrial neoplasm Diseases 0.000 description 3
- BKAYIFDRRZZKNF-VIFPVBQESA-N N-acetylcarnosine Chemical compound CC(=O)NCCC(=O)N[C@H](C(O)=O)CC1=CN=CN1 BKAYIFDRRZZKNF-VIFPVBQESA-N 0.000 description 3
- 208000034179 Neoplasms, Glandular and Epithelial Diseases 0.000 description 3
- 239000000020 Nitrocellulose Substances 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 229920002684 Sepharose Polymers 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 150000007513 acids Chemical class 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 230000004075 alteration Effects 0.000 description 3
- 230000001772 anti-angiogenic effect Effects 0.000 description 3
- 210000000481 breast Anatomy 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 239000000104 diagnostic biomarker Substances 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 210000004408 hybridoma Anatomy 0.000 description 3
- 238000003384 imaging method Methods 0.000 description 3
- 238000003365 immunocytochemistry Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 108020004999 messenger RNA Proteins 0.000 description 3
- 238000011227 neoadjuvant chemotherapy Methods 0.000 description 3
- 229920001220 nitrocellulos Polymers 0.000 description 3
- 210000001672 ovary Anatomy 0.000 description 3
- 238000012123 point-of-care testing Methods 0.000 description 3
- 229920002492 poly(sulfone) Polymers 0.000 description 3
- 238000011002 quantification Methods 0.000 description 3
- 210000003296 saliva Anatomy 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- XZKIHKMTEMTJQX-UHFFFAOYSA-N 4-Nitrophenyl Phosphate Chemical compound OP(O)(=O)OC1=CC=C([N+]([O-])=O)C=C1 XZKIHKMTEMTJQX-UHFFFAOYSA-N 0.000 description 2
- 102100028914 Catenin beta-1 Human genes 0.000 description 2
- 241000282693 Cercopithecidae Species 0.000 description 2
- 108010042086 Collagen Type IV Proteins 0.000 description 2
- 102000004266 Collagen Type IV Human genes 0.000 description 2
- 108020004414 DNA Proteins 0.000 description 2
- 201000009273 Endometriosis Diseases 0.000 description 2
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 2
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 2
- 101100328554 Homo sapiens COL4A1 gene Proteins 0.000 description 2
- 101000916173 Homo sapiens Catenin beta-1 Proteins 0.000 description 2
- 101000605639 Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Proteins 0.000 description 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 2
- 238000012773 Laboratory assay Methods 0.000 description 2
- 102000043136 MAP kinase family Human genes 0.000 description 2
- 108091054455 MAP kinase family Proteins 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241001529936 Murinae Species 0.000 description 2
- -1 PTE1V Proteins 0.000 description 2
- 229930012538 Paclitaxel Natural products 0.000 description 2
- 102100038332 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Human genes 0.000 description 2
- 206010035226 Plasma cell myeloma Diseases 0.000 description 2
- 229920001213 Polysorbate 20 Polymers 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- DZBUGLKDJFMEHC-UHFFFAOYSA-N acridine Chemical compound C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 description 2
- 125000003275 alpha amino acid group Chemical group 0.000 description 2
- 230000009830 antibody antigen interaction Effects 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 210000002469 basement membrane Anatomy 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 231100000504 carcinogenesis Toxicity 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 210000003756 cervix mucus Anatomy 0.000 description 2
- 238000012512 characterization method Methods 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 2
- 229960004316 cisplatin Drugs 0.000 description 2
- 230000002860 competitive effect Effects 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 230000003467 diminishing effect Effects 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 210000004696 endometrium Anatomy 0.000 description 2
- 208000010932 epithelial neoplasm Diseases 0.000 description 2
- 210000002744 extracellular matrix Anatomy 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 238000009396 hybridization Methods 0.000 description 2
- 230000001900 immune effect Effects 0.000 description 2
- 230000003053 immunization Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 238000007477 logistic regression Methods 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 230000000877 morphologic effect Effects 0.000 description 2
- 201000000050 myeloid neoplasm Diseases 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 238000011275 oncology therapy Methods 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 229920000620 organic polymer Polymers 0.000 description 2
- 208000025661 ovarian cyst Diseases 0.000 description 2
- 229960001592 paclitaxel Drugs 0.000 description 2
- 230000007170 pathology Effects 0.000 description 2
- 230000000737 periodic effect Effects 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920002401 polyacrylamide Polymers 0.000 description 2
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 2
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 230000035935 pregnancy Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 230000002285 radioactive effect Effects 0.000 description 2
- 239000013074 reference sample Substances 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 210000004989 spleen cell Anatomy 0.000 description 2
- 238000010561 standard procedure Methods 0.000 description 2
- 238000011272 standard treatment Methods 0.000 description 2
- 239000012089 stop solution Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 2
- 210000001138 tear Anatomy 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- UAIUNKRWKOVEES-UHFFFAOYSA-N 3,3',5,5'-tetramethylbenzidine Chemical compound CC1=C(N)C(C)=CC(C=2C=C(C)C(N)=C(C)C=2)=C1 UAIUNKRWKOVEES-UHFFFAOYSA-N 0.000 description 1
- 101800000504 3C-like protease Proteins 0.000 description 1
- 208000006678 Abdominal Neoplasms Diseases 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 208000005641 Adenomyosis Diseases 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 102000005666 Apolipoprotein A-I Human genes 0.000 description 1
- 102000036365 BRCA1 Human genes 0.000 description 1
- 108700040618 BRCA1 Genes Proteins 0.000 description 1
- 101150072950 BRCA1 gene Proteins 0.000 description 1
- 206010061692 Benign muscle neoplasm Diseases 0.000 description 1
- 101150066399 COL4A1 gene Proteins 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 208000005623 Carcinogenesis Diseases 0.000 description 1
- 208000037051 Chromosomal Instability Diseases 0.000 description 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
- 108020004635 Complementary DNA Proteins 0.000 description 1
- 108010009392 Cyclin-Dependent Kinase Inhibitor p16 Proteins 0.000 description 1
- IGXWBGJHJZYPQS-SSDOTTSWSA-N D-Luciferin Chemical compound OC(=O)[C@H]1CSC(C=2SC3=CC=C(O)C=C3N=2)=N1 IGXWBGJHJZYPQS-SSDOTTSWSA-N 0.000 description 1
- CYCGRDQQIOGCKX-UHFFFAOYSA-N Dehydro-luciferin Natural products OC(=O)C1=CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 CYCGRDQQIOGCKX-UHFFFAOYSA-N 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 206010061818 Disease progression Diseases 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010014733 Endometrial cancer Diseases 0.000 description 1
- 201000001342 Fallopian tube cancer Diseases 0.000 description 1
- 208000013452 Fallopian tube neoplasm Diseases 0.000 description 1
- BJGNCJDXODQBOB-UHFFFAOYSA-N Fivefly Luciferin Natural products OC(=O)C1CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 BJGNCJDXODQBOB-UHFFFAOYSA-N 0.000 description 1
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 description 1
- 102100030708 GTPase KRas Human genes 0.000 description 1
- 201000003741 Gastrointestinal carcinoma Diseases 0.000 description 1
- 208000031448 Genomic Instability Diseases 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 101000733802 Homo sapiens Apolipoprotein A-I Proteins 0.000 description 1
- 101000584612 Homo sapiens GTPase KRas Proteins 0.000 description 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 1
- 101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 description 1
- 101000766306 Homo sapiens Serotransferrin Proteins 0.000 description 1
- 108010082302 Human Follicle Stimulating Hormone Proteins 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 239000007836 KH2PO4 Substances 0.000 description 1
- 108060001084 Luciferase Proteins 0.000 description 1
- 239000005089 Luciferase Substances 0.000 description 1
- DDWFXDSYGUXRAY-UHFFFAOYSA-N Luciferin Natural products CCc1c(C)c(CC2NC(=O)C(=C2C=C)C)[nH]c1Cc3[nH]c4C(=C5/NC(CC(=O)O)C(C)C5CC(=O)O)CC(=O)c4c3C DDWFXDSYGUXRAY-UHFFFAOYSA-N 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 206010061269 Malignant peritoneal neoplasm Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 206010027406 Mesothelioma Diseases 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 201000004458 Myoma Diseases 0.000 description 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 description 1
- 206010057529 Ovarian cancer metastatic Diseases 0.000 description 1
- 206010058823 Ovarian mass Diseases 0.000 description 1
- 102000014160 PTEN Phosphohydrolase Human genes 0.000 description 1
- 108010011536 PTEN Phosphohydrolase Proteins 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 108090000526 Papain Proteins 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 208000000450 Pelvic Pain Diseases 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 241000276498 Pollachius virens Species 0.000 description 1
- 102000004079 Prolyl Hydroxylases Human genes 0.000 description 1
- 108010043005 Prolyl Hydroxylases Proteins 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 208000006265 Renal cell carcinoma Diseases 0.000 description 1
- 102100027103 Serine/threonine-protein kinase B-raf Human genes 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 108700025695 Suppressor Genes Proteins 0.000 description 1
- 229940123237 Taxane Drugs 0.000 description 1
- 208000024313 Testicular Neoplasms Diseases 0.000 description 1
- 102000004338 Transferrin Human genes 0.000 description 1
- 206010046543 Urinary incontinence Diseases 0.000 description 1
- 206010046798 Uterine leiomyoma Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 238000001261 affinity purification Methods 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 239000004037 angiogenesis inhibitor Substances 0.000 description 1
- 238000002963 antigen down assay Methods 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 230000009925 apoptotic mechanism Effects 0.000 description 1
- VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 208000024330 bloating Diseases 0.000 description 1
- 230000036765 blood level Effects 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 238000011088 calibration curve Methods 0.000 description 1
- 230000036952 cancer formation Effects 0.000 description 1
- 230000005773 cancer-related death Effects 0.000 description 1
- 229960004562 carboplatin Drugs 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 210000003679 cervix uteri Anatomy 0.000 description 1
- 229940044683 chemotherapy drug Drugs 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000012875 competitive assay Methods 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 238000013211 curve analysis Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000012631 diagnostic technique Methods 0.000 description 1
- 208000018554 digestive system carcinoma Diseases 0.000 description 1
- 230000005750 disease progression Effects 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- BFMYDTVEBKDAKJ-UHFFFAOYSA-L disodium;(2',7'-dibromo-3',6'-dioxido-3-oxospiro[2-benzofuran-1,9'-xanthene]-4'-yl)mercury;hydrate Chemical compound O.[Na+].[Na+].O1C(=O)C2=CC=CC=C2C21C1=CC(Br)=C([O-])C([Hg])=C1OC1=C2C=C(Br)C([O-])=C1 BFMYDTVEBKDAKJ-UHFFFAOYSA-L 0.000 description 1
- 229960003668 docetaxel Drugs 0.000 description 1
- 238000013399 early diagnosis Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 230000002357 endometrial effect Effects 0.000 description 1
- 201000009274 endometriosis of uterus Diseases 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 208000014804 familial ovarian cancer Diseases 0.000 description 1
- 201000010255 female reproductive organ cancer Diseases 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000011354 first-line chemotherapy Methods 0.000 description 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
- 238000000799 fluorescence microscopy Methods 0.000 description 1
- 229940028334 follicle stimulating hormone Drugs 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 230000004077 genetic alteration Effects 0.000 description 1
- 231100000118 genetic alteration Toxicity 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 238000001794 hormone therapy Methods 0.000 description 1
- 238000012744 immunostaining Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 102000006495 integrins Human genes 0.000 description 1
- 108010044426 integrins Proteins 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 201000010260 leiomyoma Diseases 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000009607 mammography Methods 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000009245 menopause Effects 0.000 description 1
- 210000004914 menses Anatomy 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 230000001394 metastastic effect Effects 0.000 description 1
- 206010061289 metastatic neoplasm Diseases 0.000 description 1
- 230000011987 methylation Effects 0.000 description 1
- 238000007069 methylation reaction Methods 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000003990 molecular pathway Effects 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- 201000010879 mucinous adenocarcinoma Diseases 0.000 description 1
- 230000000869 mutational effect Effects 0.000 description 1
- 230000014399 negative regulation of angiogenesis Effects 0.000 description 1
- 230000009826 neoplastic cell growth Effects 0.000 description 1
- 238000007474 nonparametric Mann- Whitney U test Methods 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 210000003101 oviduct Anatomy 0.000 description 1
- 101800000607 p15 Proteins 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 229940055729 papain Drugs 0.000 description 1
- 235000019834 papain Nutrition 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 201000002524 peritoneal carcinoma Diseases 0.000 description 1
- 210000004303 peritoneum Anatomy 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 238000009258 post-therapy Methods 0.000 description 1
- 230000004481 post-translational protein modification Effects 0.000 description 1
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000009597 pregnancy test Methods 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 230000006337 proteolytic cleavage Effects 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000004451 qualitative analysis Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 239000012857 radioactive material Substances 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000000405 serological effect Effects 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 238000012289 standard assay Methods 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 description 1
- 230000002381 testicular Effects 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 239000012581 transferrin Substances 0.000 description 1
- 206010044412 transitional cell carcinoma Diseases 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 201000007954 uterine fibroid Diseases 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57449—Specifically defined cancers of ovaries
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA3163199A CA3163199A1 (fr) | 2022-06-16 | 2022-06-16 | Biomarqueur du cancer des ovaires et ses procedes d~utilisation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA3163199A CA3163199A1 (fr) | 2022-06-16 | 2022-06-16 | Biomarqueur du cancer des ovaires et ses procedes d~utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3163199A1 true CA3163199A1 (fr) | 2023-12-16 |
Family
ID=89158665
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3163199A Pending CA3163199A1 (fr) | 2022-06-16 | 2022-06-16 | Biomarqueur du cancer des ovaires et ses procedes d~utilisation |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA3163199A1 (fr) |
-
2022
- 2022-06-16 CA CA3163199A patent/CA3163199A1/fr active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1987360B1 (fr) | Méthodes permettant d'identifier des patientes présentant un risque accru d'être atteintes d'un cancer de l'ovaire et compositions associées | |
| DUFFY et al. | CA125 in ovarian cancer: European Group on Tumor Markers guidelines for clinical use | |
| Leung et al. | Folate-receptor 1 (FOLR1) protein is elevated in the serum of ovarian cancer patients | |
| JP5312684B2 (ja) | 癌のマーカーとしてのｄｐｐｉｖ／セプラーゼの使用 | |
| WO2022063156A1 (fr) | Biomarqueur du cancer du sein et son application | |
| JP2014211452A (ja) | 結腸直腸癌のためのマーカーパネル | |
| WO2007082144A9 (fr) | Methode permettant de detecter un cancer a l'aide de b7-h1 et de survivine | |
| JP6216732B2 (ja) | 癌の診断方法ならびに癌患者の全生存期間および無病生存期間の決定方法 | |
| WO2010136629A1 (fr) | Méthodes pour le diagnostic ou le pronostic du cancer colorectal | |
| US20220390453A1 (en) | Ovarian cancer biomarker and methods of using same | |
| US20210181200A1 (en) | Ovarian cancer biomarker and methods of using same | |
| CA3163199A1 (fr) | Biomarqueur du cancer des ovaires et ses procedes d~utilisation | |
| CA3065603A1 (fr) | Biomarqueur du cancer des ovaires et ses procedes d`utilisation | |
| US8252542B2 (en) | Serpin B 13 as a marker for squamous cell carcinoma of the lung | |
| US20070269831A1 (en) | Method for Early Detection of Ovarian Cancer | |
| US20110165577A1 (en) | Selection of colorectal cancer patients for neo-adjuvant and adjuvent systemic anti-cancer treatment | |
| US20230375550A1 (en) | Method for diagnosing breast cancer by using biomarker | |
| US20130095483A1 (en) | Predictive biomarkers for breast cancer | |
| TW202242146A (zh) | 肺癌的檢測方法 | |
| Duffy et al. | National Academy of Clinical Biochemistry guidelines for the use of tumor markers in breast cancer | |
| WO2005040805A1 (fr) | Utilisation de la proteine masp en tant que marqueur pour le cancer du sein | |
| ÖZDEMİR | CLINICAL USE OF TUMOR MARKERS | |
| WO2017060840A1 (fr) | Utilisation de la protéine htra1 pour la détection précoce du cancer colorectal | |
| EP2273272A1 (fr) | Procédé permettant de prédire les résultats d'une chimiothérapie pour traiter le cancer des ovaires |