CA3150316A1 - Agents de degradation de l'erk5 utilises comme agents therapeutiques dans le cancer et les maladies inflammatoires - Google Patents
Agents de degradation de l'erk5 utilises comme agents therapeutiques dans le cancer et les maladies inflammatoires Download PDFInfo
- Publication number
- CA3150316A1 CA3150316A1 CA3150316A CA3150316A CA3150316A1 CA 3150316 A1 CA3150316 A1 CA 3150316A1 CA 3150316 A CA3150316 A CA 3150316A CA 3150316 A CA3150316 A CA 3150316A CA 3150316 A1 CA3150316 A1 CA 3150316A1
- Authority
- CA
- Canada
- Prior art keywords
- bispecific compound
- optionally substituted
- cancer
- compound
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne des composés bispécifiques (agents de dégradation) qui ciblent l'ERK5 à des fins de dégradation. L'invention concerne également des compositions pharmaceutiques contenant les agents de dégradation et des procédés d'utilisation desdits composés pour traiter le cancer et les maladies inflammatoires.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962907377P | 2019-09-27 | 2019-09-27 | |
US62/907,377 | 2019-09-27 | ||
PCT/US2020/052371 WO2021061894A1 (fr) | 2019-09-27 | 2020-09-24 | Agents de dégradation de l'erk5 utilisés comme agents thérapeutiques dans le cancer et les maladies inflammatoires |
Publications (1)
Publication Number | Publication Date |
---|---|
CA3150316A1 true CA3150316A1 (fr) | 2021-04-01 |
Family
ID=75166154
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA3150316A Pending CA3150316A1 (fr) | 2019-09-27 | 2020-09-24 | Agents de degradation de l'erk5 utilises comme agents therapeutiques dans le cancer et les maladies inflammatoires |
Country Status (5)
Country | Link |
---|---|
US (1) | US20220378919A1 (fr) |
EP (1) | EP4034132A4 (fr) |
AU (1) | AU2020356484A1 (fr) |
CA (1) | CA3150316A1 (fr) |
WO (1) | WO2021061894A1 (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022078350A1 (fr) * | 2020-10-14 | 2022-04-21 | Ranok Therapeutics (Hangzhou) Co. Ltd. | Méthodes et compositions pour la dégradation ciblée de protéines |
KR102604801B1 (ko) | 2021-08-10 | 2023-11-22 | (주) 업테라 | 신규 plk1 분해 유도 화합물 |
WO2023044482A1 (fr) * | 2021-09-20 | 2023-03-23 | Dana-Farber Cancer Institute, Inc. | Agents de dégradation erk5 et leurs utilisations |
GB202202199D0 (en) | 2022-02-18 | 2022-04-06 | Cancer Research Tech Ltd | Compounds |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2680757A1 (fr) * | 2007-03-22 | 2008-09-25 | F. Hoffmann-La Roche Ag | Pyrimidodiazepines substituees utiles en tant qu'inhibiteurs de plk1 |
CA2700979C (fr) * | 2007-09-28 | 2017-06-20 | Cyclacel Limited | Derives de pyrimidine comme inhibiteurs de proteine kinases |
EP3255047B1 (fr) * | 2009-01-06 | 2021-06-30 | Dana-Farber Cancer Institute, Inc. | Composés d'échafaudage de kinase pyrimido-diazépinone et procédés de traitement de troubles |
JP6815318B2 (ja) * | 2014-12-23 | 2021-01-20 | ダナ−ファーバー キャンサー インスティテュート,インコーポレイテッド | 二官能性分子によって標的化タンパク質分解を誘導する方法 |
WO2017007612A1 (fr) * | 2015-07-07 | 2017-01-12 | Dana-Farber Cancer Institute, Inc. | Procédés pour induire la dégradation ciblée de protéines par des molécules bifonctionnelles |
US20190374657A1 (en) * | 2017-02-08 | 2019-12-12 | Dana-Farber Cancer Institute, Inc. | Tunable endogenous protein degradation with heterobifunctional compounds |
US20230158158A1 (en) * | 2020-03-27 | 2023-05-25 | Uppthera | Pyrazolo quinazoline derivative compounds inducing selective degradation of plk1 |
-
2020
- 2020-09-24 AU AU2020356484A patent/AU2020356484A1/en active Pending
- 2020-09-24 WO PCT/US2020/052371 patent/WO2021061894A1/fr active Application Filing
- 2020-09-24 EP EP20869939.7A patent/EP4034132A4/fr active Pending
- 2020-09-24 US US17/761,096 patent/US20220378919A1/en active Pending
- 2020-09-24 CA CA3150316A patent/CA3150316A1/fr active Pending
Also Published As
Publication number | Publication date |
---|---|
US20220378919A1 (en) | 2022-12-01 |
WO2021061894A1 (fr) | 2021-04-01 |
AU2020356484A1 (en) | 2022-03-17 |
EP4034132A4 (fr) | 2023-10-11 |
EP4034132A1 (fr) | 2022-08-03 |
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