CA3145291A1 - Methods for treating ran protein-associated neurological diseases - Google Patents

Methods for treating ran protein-associated neurological diseases Download PDF

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Publication number
CA3145291A1
CA3145291A1 CA3145291A CA3145291A CA3145291A1 CA 3145291 A1 CA3145291 A1 CA 3145291A1 CA 3145291 A CA3145291 A CA 3145291A CA 3145291 A CA3145291 A CA 3145291A CA 3145291 A1 CA3145291 A1 CA 3145291A1
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Prior art keywords
poly
seq
ran
protein
antibody
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CA3145291A
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English (en)
French (fr)
Inventor
Laura Ranum
Lien Nguyen
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University of Florida Research Foundation Inc
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University of Florida Research Foundation Inc
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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CA3145291A 2019-07-05 2020-07-02 Methods for treating ran protein-associated neurological diseases Pending CA3145291A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962871031P 2019-07-05 2019-07-05
US62/871,031 2019-07-05
US202063025096P 2020-05-14 2020-05-14
US63/025,096 2020-05-14
PCT/US2020/040725 WO2021007110A1 (en) 2019-07-05 2020-07-02 Methods for treating ran protein-associated neurological diseases

Publications (1)

Publication Number Publication Date
CA3145291A1 true CA3145291A1 (en) 2021-01-14

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ID=74114201

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CA3145291A Pending CA3145291A1 (en) 2019-07-05 2020-07-02 Methods for treating ran protein-associated neurological diseases

Country Status (6)

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US (1) US20220267776A1 (https=)
EP (1) EP3994159A4 (https=)
JP (2) JP7579589B2 (https=)
AU (1) AU2020310843A1 (https=)
CA (1) CA3145291A1 (https=)
WO (1) WO2021007110A1 (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10509045B2 (en) 2015-05-29 2019-12-17 University Of Florida Research Foundation, Incorporated Methods for diagnosing Huntington's disease
US10940161B2 (en) 2016-04-04 2021-03-09 University Of Florida Research Foundation, Incorporated Manipulation of EIF3 to modulate repeat associated non-ATG (RAN) translation
WO2018195110A1 (en) 2017-04-17 2018-10-25 University Of Florida Research Foundation, Incorporated Regolation of ran translation by pkr and eif2a-p pathways
AU2018308088B2 (en) 2017-07-25 2025-05-29 Truebinding, Inc. Treating cancer by blocking the interaction of TIM-3 and its ligand
JP2020535448A (ja) 2017-09-25 2020-12-03 ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． Ｒａｎタンパク質の検出のための免役アッセイ
US11903910B2 (en) 2017-09-26 2024-02-20 University Of Florida Research Foundation, Incorporated Use of metformin and analogs thereof to reduce RAN protein levels in the treatment of neurological disorders
AU2020214796A1 (en) 2019-01-30 2021-07-29 Truebinding, Inc. Anti-Gal3 antibodies and uses thereof
WO2021055880A1 (en) 2019-09-20 2021-03-25 University Of Florida Researchfoundation, Incorporated Detection of antibodies against ran proteins from serum and tissue lysates
WO2021242776A2 (en) 2020-05-26 2021-12-02 Truebinding, Inc. Methods of treating inflammatory diseases by blocking galectin-3
WO2023077153A1 (en) * 2021-11-01 2023-05-04 University Of Florida Research Foundation, Incorporated Poly-ga proteins in alzheimer's disease
WO2023102111A1 (en) 2021-12-01 2023-06-08 University Of Florida Research Foundation, Incorporated Small molecule inhibitors of repeat associated non-aug (ran) translation and combination therapies
AU2023373378A1 (en) * 2022-11-01 2025-04-24 University Of Florida Research Foundation, Incorporated Interrupted ran proteins in disease
WO2024173816A1 (en) * 2023-02-17 2024-08-22 The University Of North Carolina At Chapel Hill Methods of detecting telomere-encoded dipeptide repeat proteins and therapeutic applications
CN116693621B (zh) * 2023-03-02 2023-11-14 东北农业大学 抑制革兰氏阴性菌的窄谱抗菌肽pc及其制备方法和应用
WO2025019730A1 (en) * 2023-07-20 2025-01-23 University Of Florida Research Foundation, Incorporated Engineered ga antibodies for therapy development
WO2025128551A1 (en) * 2023-12-11 2025-06-19 University Of Florida Research Foundation, Incorporated Aav-based anti-ga therapy

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2948777T (pt) * 2013-01-22 2019-09-26 Deutsches Zentrum Fuer Neurodegenerative Erkrankungen E V Proteínas de repetição por dipeptídeos como alvo terapêutico em doenças neurodegenerativas com expansão de hexanucleotídico repetido
WO2014159247A1 (en) * 2013-03-14 2014-10-02 University Of Florida Research Foundation, Inc. Di-amino acid repeat-containing proteins associated with als
EP3177322A4 (en) * 2014-08-08 2018-07-18 Alector LLC Anti-trem2 antibodies and methods of use thereof
JP6432023B2 (ja) * 2014-12-02 2018-12-05 国立大学法人 東京医科歯科大学 脊髄小脳失調症３１型（ｓｃａ３１）治療剤
US10509045B2 (en) * 2015-05-29 2019-12-17 University Of Florida Research Foundation, Incorporated Methods for diagnosing Huntington's disease
US10940161B2 (en) * 2016-04-04 2021-03-09 University Of Florida Research Foundation, Incorporated Manipulation of EIF3 to modulate repeat associated non-ATG (RAN) translation
TW201920672A (zh) * 2017-08-08 2019-06-01 新加坡商波濤生命科學有限公司 寡核苷酸組合物及其使用方法
JP2020535448A (ja) * 2017-09-25 2020-12-03 ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． Ｒａｎタンパク質の検出のための免役アッセイ
US11903910B2 (en) * 2017-09-26 2024-02-20 University Of Florida Research Foundation, Incorporated Use of metformin and analogs thereof to reduce RAN protein levels in the treatment of neurological disorders

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Publication number Publication date
WO2021007110A1 (en) 2021-01-14
JP7579589B2 (ja) 2024-11-08
AU2020310843A1 (en) 2022-01-20
US20220267776A1 (en) 2022-08-25
EP3994159A1 (en) 2022-05-11
EP3994159A4 (en) 2023-08-09
JP2022538926A (ja) 2022-09-06
JP2025026843A (ja) 2025-02-26

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