CA3144356A1 - A genetic pharmacopeia for comprehensive functional profiling of human cancers - Google Patents

A genetic pharmacopeia for comprehensive functional profiling of human cancers Download PDF

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Publication number
CA3144356A1
CA3144356A1 CA3144356A CA3144356A CA3144356A1 CA 3144356 A1 CA3144356 A1 CA 3144356A1 CA 3144356 A CA3144356 A CA 3144356A CA 3144356 A CA3144356 A CA 3144356A CA 3144356 A1 CA3144356 A1 CA 3144356A1
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gene
library
cancer
sequence
reagents
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CA3144356A
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English (en)
French (fr)
Inventor
Christian SCHMEDT
Srihari C. SAMPATH
Srinath C. SAMPATH
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Function Oncology Inc
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Function Oncology Inc
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
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    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1082—Preparation or screening gene libraries by chromosomal integration of polynucleotide sequences, HR-, site-specific-recombination, transposons, viral vectors
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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  • Health & Medical Sciences (AREA)
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  • Physics & Mathematics (AREA)
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  • Crystallography & Structural Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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CA3144356A 2019-06-21 2020-06-18 A genetic pharmacopeia for comprehensive functional profiling of human cancers Pending CA3144356A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962865047P 2019-06-21 2019-06-21
US62/865,047 2019-06-21
PCT/US2020/038503 WO2020257504A1 (en) 2019-06-21 2020-06-18 A genetic pharmacopeia for comprehensive functional profiling of human cancers

Publications (1)

Publication Number Publication Date
CA3144356A1 true CA3144356A1 (en) 2020-12-24

Family

ID=74040921

Family Applications (1)

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CA3144356A Pending CA3144356A1 (en) 2019-06-21 2020-06-18 A genetic pharmacopeia for comprehensive functional profiling of human cancers

Country Status (8)

Country Link
US (1) US20220244244A1 (enExample)
EP (1) EP3987087A4 (enExample)
JP (1) JP2022538084A (enExample)
KR (1) KR20220052902A (enExample)
CN (1) CN114450440A (enExample)
AU (1) AU2020294772A1 (enExample)
CA (1) CA3144356A1 (enExample)
WO (1) WO2020257504A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3443081A4 (en) 2016-04-13 2019-10-30 Duke University CRISPR / CAS9-BASED REPRESSORS FOR IN VIVO SHUT-OFF OF GEN-TARGETS AND METHOD OF USE
US12509492B2 (en) 2018-01-19 2025-12-30 Duke University Genome engineering with CRISPR-Cas systems in eukaryotes
CA3110837A1 (en) 2018-08-28 2020-03-05 Vor Biopharma Inc. Genetically engineered hematopoietic stem cells and uses thereof
TWI887234B (zh) 2019-04-14 2025-06-21 美國公爵大學 治療杜興氏（ｄｕｃｈｅｎｎｅ）肌肉失養症之大型突變熱點之ａａｖ載體介導之刪除
WO2022056489A1 (en) * 2020-09-14 2022-03-17 Vor Biopharma, Inc. Compositions and methods for cd38 modification
WO2022072643A1 (en) * 2020-09-30 2022-04-07 Vor Biopharma Inc. Compositions and methods for cd30 gene modification
US11802866B2 (en) * 2021-07-08 2023-10-31 Medic Life Sciences Inc. High-throughput screening system for identification of novel drugs and drug targets
IL310118A (en) * 2021-07-16 2024-03-01 Orthobio Therapeutics Inc Gene editing to improve joint function
WO2023081200A2 (en) * 2021-11-03 2023-05-11 Intellia Therapeutics, Inc. Cd38 compositions and methods for immunotherapy
CN114703191A (zh) * 2022-04-19 2022-07-05 华南农业大学 基于crsipr技术构建rictor基因敲除细胞株的方法及其应用
US20260234583A1 (en) * 2023-02-10 2026-08-13 Integrate Bioscience Llc Personalized crispr profiling for cancer
WO2024220947A2 (en) * 2023-04-21 2024-10-24 Duke University Epigenetic targets for enhancing cancer immunotherapy
EP4782540A1 (en) * 2023-09-19 2026-07-29 National University Corporation Tokai National Higher Education And Research System Single-stranded polynucleotide

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007109527A1 (en) * 2006-03-17 2007-09-27 Bristol-Myers Squibb Company Methods of identifying and treating individuals exhibiting mutant bcr/abl kinase polypeptides
WO2015065964A1 (en) * 2013-10-28 2015-05-07 The Broad Institute Inc. Functional genomics using crispr-cas systems, compositions, methods, screens and applications thereof

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Publication number Publication date
US20220244244A1 (en) 2022-08-04
EP3987087A1 (en) 2022-04-27
AU2020294772A1 (en) 2022-02-03
KR20220052902A (ko) 2022-04-28
WO2020257504A1 (en) 2020-12-24
JP2022538084A (ja) 2022-08-31
EP3987087A4 (en) 2023-11-15
CN114450440A (zh) 2022-05-06

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