CA3142948A1 - Artificial expression constructs for selectively modulating gene expression in selected neuronal cell populations - Google Patents

Artificial expression constructs for selectively modulating gene expression in selected neuronal cell populations Download PDF

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Publication number
CA3142948A1
CA3142948A1 CA3142948A CA3142948A CA3142948A1 CA 3142948 A1 CA3142948 A1 CA 3142948A1 CA 3142948 A CA3142948 A CA 3142948A CA 3142948 A CA3142948 A CA 3142948A CA 3142948 A1 CA3142948 A1 CA 3142948A1
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Prior art keywords
ehgt
expression construct
bghpa
vector
wpre3
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CA3142948A
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English (en)
French (fr)
Inventor
Jonathan Ting
Boaz P. LEVI
Bosiljka Tasic
John K. Mich
Erik HESS
Edward Sebastian LEIN
Lucas T. GRAYBUCK
Tanya DAIGLE
Hongkui Zeng
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Allen Institute
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Allen Institute
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Publication of CA3142948A1 publication Critical patent/CA3142948A1/en
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    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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CA3142948A 2019-02-15 2020-02-14 Artificial expression constructs for selectively modulating gene expression in selected neuronal cell populations Pending CA3142948A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962806686P 2019-02-15 2019-02-15
US201962806660P 2019-02-15 2019-02-15
US62/806,660 2019-02-15
US62/806,686 2019-02-15
US201962874859P 2019-07-16 2019-07-16
US62/874,859 2019-07-16
PCT/US2020/018416 WO2020168279A2 (en) 2019-02-15 2020-02-14 Artificial expression constructs for selectively modulating gene expression in selected neuronal cell populations

Publications (1)

Publication Number Publication Date
CA3142948A1 true CA3142948A1 (en) 2020-08-20

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CA3142948A Pending CA3142948A1 (en) 2019-02-15 2020-02-14 Artificial expression constructs for selectively modulating gene expression in selected neuronal cell populations

Country Status (6)

Country Link
US (1) US20220249703A1 (https=)
EP (1) EP3923995A4 (https=)
JP (2) JP7608348B2 (https=)
AU (1) AU2020223367A1 (https=)
CA (1) CA3142948A1 (https=)
WO (1) WO2020168279A2 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2021261359A1 (en) * 2020-04-21 2022-12-08 Allen Institute Artificial expression constructs for selectively modulating gene expression in neocortical layer 5 glutamatergic neurons
WO2022103859A1 (en) * 2020-11-10 2022-05-19 Allen Institute Artificial expression constructs for modulating gene expression in chandelier cells
WO2022212585A1 (en) * 2021-03-30 2022-10-06 Allen Institute Artificial expression constructs for modulating gene expression in claustrum neurons
WO2022246276A2 (en) * 2021-05-21 2022-11-24 Allen Institute Artificial expression constructs for modulating gene expression in neurons within the thalamus
EP4413142A4 (en) * 2021-10-05 2025-11-05 Allen Inst ARTIFICIAL EXPRESSION CONSTRUCTIONS TO MODULATE GENE EXPRESSION IN THE CEREBELLUM AND IN A SECONDARY CELL TYPE
AU2024308266A1 (en) * 2023-06-28 2025-12-18 Allen Institute Artificial expression constructs for modulating gene expression in cardiomyocytes

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69918090T2 (de) * 1998-04-24 2005-06-16 University Of Florida, Gainesville Rekombinanter adeno-assoziierter viraler vektor, der alpha-1 antitrypsin kodiert, zur gentherapie
US20070037165A1 (en) * 2000-09-08 2007-02-15 Applera Corporation Polymorphisms in known genes associated with human disease, methods of detection and uses thereof
CA2817256A1 (en) * 2010-11-12 2012-05-18 The General Hospital Corporation Polycomb-associated non-coding rnas
AU2013201287B2 (en) * 2012-03-06 2015-05-14 Duke University Synthetic regulation of gene expression
WO2013155222A2 (en) * 2012-04-10 2013-10-17 The Regents Of The University Of California Brain-specific enhancers for cell-based therapy
US9790490B2 (en) * 2015-06-18 2017-10-17 The Broad Institute Inc. CRISPR enzymes and systems
KR102423442B1 (ko) 2015-12-11 2022-07-20 캘리포니아 인스티튜트 오브 테크놀로지 아데노-관련 바이러스를 지시하기 위한 타겟팅 펩타이드
US10973930B2 (en) * 2016-02-18 2021-04-13 The Penn State Research Foundation Generating GABAergic neurons in brains
WO2020097121A1 (en) * 2018-11-05 2020-05-14 Allen Institute Artificial expression constructs for selectively modulating gene expression in excitatory cortical neurons

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Publication number Publication date
WO2020168279A2 (en) 2020-08-20
WO2020168279A3 (en) 2020-09-24
US20220249703A1 (en) 2022-08-11
JP7608348B2 (ja) 2025-01-06
EP3923995A2 (en) 2021-12-22
JP2025041709A (ja) 2025-03-26
JP2022520437A (ja) 2022-03-30
EP3923995A4 (en) 2023-05-17
AU2020223367A1 (en) 2021-10-07

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