CA3137125C - Derives de camptothecine - Google Patents

Derives de camptothecine

Info

Publication number
CA3137125C
CA3137125C CA3137125A CA3137125A CA3137125C CA 3137125 C CA3137125 C CA 3137125C CA 3137125 A CA3137125 A CA 3137125A CA 3137125 A CA3137125 A CA 3137125A CA 3137125 C CA3137125 C CA 3137125C
Authority
CA
Canada
Prior art keywords
ala
gly
alkylene
val
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3137125A
Other languages
English (en)
Other versions
CA3137125A1 (fr
Inventor
Ravi Chari
Wayne C. Widdison
Wei Li
David P. Pleynet
Original Assignee
Immunogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunogen Inc filed Critical Immunogen Inc
Priority claimed from PCT/US2020/027831 external-priority patent/WO2020219287A1/fr
Publication of CA3137125A1 publication Critical patent/CA3137125A1/fr
Application granted granted Critical
Publication of CA3137125C publication Critical patent/CA3137125C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Abstract

L'invention concerne de nouveaux composés cytotoxiques, et des conjugués cytotoxiques comprenant ces composés cytotoxiques et des agents de liaison cellulaire. Plus spécifiquement, l'invention concerne de nouveaux dérivés de camptothécine de ceux-ci, des intermédiaires de ceux-ci, des conjugués de ceux-ci, et des sels pharmaceutiquement acceptables de ceux-ci, qui sont utiles en tant que médicaments, en particulier en tant qu'agents anti-prolifératifs (agents anticancéreux).
CA3137125A 2019-04-26 2020-04-10 Derives de camptothecine Active CA3137125C (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962839440P 2019-04-26 2019-04-26
US62/839,440 2019-04-26
US201962875169P 2019-07-17 2019-07-17
US62/875,169 2019-07-17
US202062978159P 2020-02-18 2020-02-18
US62/978,159 2020-02-18
PCT/US2020/027831 WO2020219287A1 (fr) 2019-04-26 2020-04-10 Dérivés de camptothécine

Publications (2)

Publication Number Publication Date
CA3137125A1 CA3137125A1 (fr) 2020-10-29
CA3137125C true CA3137125C (fr) 2026-03-10

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