CA3119599A1 - Als treatment using induced regulatory t (itreg) cells - Google Patents

Als treatment using induced regulatory t (itreg) cells Download PDF

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Publication number
CA3119599A1
CA3119599A1 CA3119599A CA3119599A CA3119599A1 CA 3119599 A1 CA3119599 A1 CA 3119599A1 CA 3119599 A CA3119599 A CA 3119599A CA 3119599 A CA3119599 A CA 3119599A CA 3119599 A1 CA3119599 A1 CA 3119599A1
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Prior art keywords
cells
subject
treg
cell
administered
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CA3119599A
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English (en)
French (fr)
Inventor
Daniel Harding FOWLER
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Rapa Therapeutics LLC
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Rapa Therapeutics LLC
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
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    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
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CA3119599A 2018-11-16 2019-11-15 Als treatment using induced regulatory t (itreg) cells Pending CA3119599A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862768176P 2018-11-16 2018-11-16
US62/768,176 2018-11-16
US201962927075P 2019-10-28 2019-10-28
US62/927,075 2019-10-28
PCT/US2019/061818 WO2020102731A1 (en) 2018-11-16 2019-11-15 ALS TREATMENT USING INDUCED REGULATORY T (iTREG) CELLS

Publications (1)

Publication Number Publication Date
CA3119599A1 true CA3119599A1 (en) 2020-05-22

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ID=70730603

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Application Number Title Priority Date Filing Date
CA3119599A Pending CA3119599A1 (en) 2018-11-16 2019-11-15 Als treatment using induced regulatory t (itreg) cells

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US (2) US12239647B2 (enExample)
EP (1) EP3880306A4 (enExample)
JP (2) JP7539881B2 (enExample)
KR (1) KR20210102264A (enExample)
CN (2) CN113573778B (enExample)
AU (1) AU2019379604B2 (enExample)
CA (1) CA3119599A1 (enExample)
WO (1) WO2020102731A1 (enExample)

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WO2021231806A1 (en) * 2020-05-13 2021-11-18 Rapa Therapeutics, Llc Antigen presenting t cells, sensitized, manufactured t cells and methods of treatment using the same
EP4150060A4 (en) * 2020-05-13 2024-06-19 Rapa Therapeutics, LLC TREATMENT OR PREVENTION OF PRO-INFLAMMATORY DISEASES OR CONDITIONS USING INDUCED REGULATORY T CELLS (IT)
EP4600352A1 (en) * 2022-09-26 2025-08-13 Kyoto University T cell production method

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