CA3114618C - Derivatives of relebactam and uses thereof - Google Patents
Derivatives of relebactam and uses thereof Download PDFInfo
- Publication number
- CA3114618C CA3114618C CA3114618A CA3114618A CA3114618C CA 3114618 C CA3114618 C CA 3114618C CA 3114618 A CA3114618 A CA 3114618A CA 3114618 A CA3114618 A CA 3114618A CA 3114618 C CA3114618 C CA 3114618C
- Authority
- CA
- Canada
- Prior art keywords
- substituted
- alkyl
- compound
- formula
- heterocycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862739746P | 2018-10-01 | 2018-10-01 | |
| US62/739,746 | 2018-10-01 | ||
| PCT/US2019/053990 WO2020072442A1 (en) | 2018-10-01 | 2019-10-01 | Derivatives of relebactam and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA3114618A1 CA3114618A1 (en) | 2020-04-09 |
| CA3114618C true CA3114618C (en) | 2023-09-05 |
Family
ID=68242885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3114618A Active CA3114618C (en) | 2018-10-01 | 2019-10-01 | Derivatives of relebactam and uses thereof |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11180500B2 (https=) |
| EP (1) | EP3860999B9 (https=) |
| JP (1) | JP7437847B2 (https=) |
| CA (1) | CA3114618C (https=) |
| ES (1) | ES2991492T3 (https=) |
| WO (1) | WO2020072442A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119431373B (zh) * | 2024-07-24 | 2025-08-08 | 科睿迪(南京)医药科技有限公司 | 一种β-内酰胺酶抑制剂及其用途 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3658849A (en) | 1969-02-19 | 1972-04-25 | Reynolds Tobacco Co R | Treatment of 2-substituted aldehydes with lead dioxide |
| DE3045373A1 (de) | 1980-12-02 | 1982-07-01 | Henkel KGaA, 4000 Düsseldorf | Verwendung von estern der 3-hydrody-2,2-dimethylpropionsaeure als riechstoffe, diese enthaltende riechstoffkompositionen und 3-hydroxy-2,2-dimethyl-propionsaeurepropylester |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| IT1270594B (it) | 1994-07-07 | 1997-05-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida |
| TR200003199T2 (tr) * | 1998-05-01 | 2001-03-21 | Kyoto Pharmaceutical Industries, Ltd. | Karbapenem türevleri, bunların kullanımı ve ara birleşiği |
| FR2812635B1 (fr) | 2000-08-01 | 2002-10-11 | Aventis Pharma Sa | Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens |
| WO2002092606A1 (en) | 2001-05-15 | 2002-11-21 | Takeda Chemical Industries, Ltd. | Fused imidazolidine derivatives, process for preparation of the same and use thereof |
| WO2009151392A1 (en) | 2008-06-14 | 2009-12-17 | Astrazeneca Ab | Novel derivatives of 11-piperazin-l-yldibenzo [b,f] [1,4] thiazepine for treating at least one syndrome or condition associated with schizophrenia and other psychotic disorders |
| TW200808731A (en) | 2006-03-30 | 2008-02-16 | Tanabe Seiyaku Co | A process for preparing tetrahydroquinoline derivatives |
| US20090082464A1 (en) | 2007-09-07 | 2009-03-26 | Bernd Jandeleit | Externally masked neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use |
| EP2217564A1 (en) | 2007-09-07 | 2010-08-18 | XenoPort, Inc. | Complex pantoic acid ester neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use |
| US20090099253A1 (en) | 2007-10-15 | 2009-04-16 | Xenoport, Inc. | Internally Masked Neopentyl Sulfonyl Ester Cyclization Release Prodrugs of Acamprosate, Compositions Thereof, and Methods of Use |
| WO2009091856A2 (en) | 2008-01-18 | 2009-07-23 | Merck & Co., Inc. | Beta-lactamase inhibitors |
| GB0801401D0 (en) | 2008-01-25 | 2008-03-05 | Barry Callebaut Ag | Composition |
| WO2009100045A1 (en) | 2008-02-04 | 2009-08-13 | Translational Genomics Research Institute | Compounds, pharmaceutical compositions and methods of use of hydroxamic acid derivatives |
| WO2010032147A2 (en) | 2008-09-19 | 2010-03-25 | Pfizer Inc. | Hydroxamic acid derivatives useful as antibacterial agents |
| WO2010065709A2 (en) | 2008-12-03 | 2010-06-10 | Amin Khan | Hydroxamic acid derivatives, preparation and therapeutic uses thereof |
| US20120053350A1 (en) * | 2009-04-30 | 2012-03-01 | Ian Mangion | Preparation of alkyl esters of n-protected oxo-azacycloalkylcarboxylic acids |
| US8859776B2 (en) | 2009-10-14 | 2014-10-14 | Merck Sharp & Dohme Corp. | Substituted piperidines that increase p53 activity and the uses thereof |
| CA2796750C (en) | 2010-04-20 | 2017-09-19 | Taisho Pharmaceutical Co., Ltd. | Novel hydroxamic acid derivative |
| WO2011150380A1 (en) | 2010-05-28 | 2011-12-01 | Xenoport, Inc. | Methods of treatment of fragile x syndrome, down's syndrome, autism and related disorders |
| US8772490B2 (en) | 2010-12-22 | 2014-07-08 | Meiji Seika Pharma Co., Ltd. | Optically active diazabicyclooctane derivatives and process for preparing the same |
| PL2657234T3 (pl) | 2010-12-22 | 2017-06-30 | Meiji Seika Pharma Co., Ltd. | Optycznie czynna pochodna diazabicyklooktanowa i sposób jej wytwarzania |
| HUE027447T2 (en) | 2011-05-30 | 2016-09-28 | Sumitomo Chemical Co | Cyclohexanone compounds and herbicides containing them |
| US8796257B2 (en) | 2011-12-02 | 2014-08-05 | Naeja Pharmaceutical Inc. | Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors |
| BR112017004796A2 (pt) | 2014-09-12 | 2017-12-12 | Toyama Chemical Co Ltd | método para utilizar derivados de ácido hidroxâmico e substância antibacterial em combinação |
| RU2017112319A (ru) | 2014-09-12 | 2018-10-12 | Тояма Кемикал Ко., Лтд. | Новая фармацевтическая композиция, содержащая производное гидроксамовой кислоты или его соль |
| WO2016116788A1 (en) | 2015-01-24 | 2016-07-28 | Wockhardt Limited | Nitrogen containing bicyclic compounds and their use in treatment of bacterial infections |
| EP3281942A4 (en) | 2015-09-16 | 2018-08-15 | Xuanzhu Pharma Co., Ltd. | B-lactamase inhibitor and application thereof |
| US20170165371A1 (en) | 2017-02-22 | 2017-06-15 | Joel Steven Goldberg | Novel synthesis of potential ester prodrugs |
| US10085999B1 (en) | 2017-05-10 | 2018-10-02 | Arixa Pharmaceuticals, Inc. | Beta-lactamase inhibitors and uses thereof |
| EP3676247B8 (en) | 2017-10-02 | 2023-04-12 | Arixa Pharmaceuticals, Inc. | Aztreonam derivatives and uses thereof |
-
2019
- 2019-10-01 CA CA3114618A patent/CA3114618C/en active Active
- 2019-10-01 EP EP19787552.9A patent/EP3860999B9/en active Active
- 2019-10-01 JP JP2021517784A patent/JP7437847B2/ja active Active
- 2019-10-01 WO PCT/US2019/053990 patent/WO2020072442A1/en not_active Ceased
- 2019-10-01 ES ES19787552T patent/ES2991492T3/es active Active
- 2019-10-01 US US16/589,498 patent/US11180500B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3860999C0 (en) | 2024-06-05 |
| ES2991492T3 (es) | 2024-12-03 |
| EP3860999A1 (en) | 2021-08-11 |
| US11180500B2 (en) | 2021-11-23 |
| JP7437847B2 (ja) | 2024-02-26 |
| WO2020072442A1 (en) | 2020-04-09 |
| JP2022511392A (ja) | 2022-01-31 |
| EP3860999B9 (en) | 2024-08-14 |
| CA3114618A1 (en) | 2020-04-09 |
| EP3860999B1 (en) | 2024-06-05 |
| US20200102307A1 (en) | 2020-04-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20210326 |