CA3105039A1 - Stability of vitamin d in .beta.-hydroxy-.beta.-methylbutyrate (hmb) - Google Patents

Stability of vitamin d in .beta.-hydroxy-.beta.-methylbutyrate (hmb) Download PDF

Info

Publication number
CA3105039A1
CA3105039A1 CA3105039A CA3105039A CA3105039A1 CA 3105039 A1 CA3105039 A1 CA 3105039A1 CA 3105039 A CA3105039 A CA 3105039A CA 3105039 A CA3105039 A CA 3105039A CA 3105039 A1 CA3105039 A1 CA 3105039A1
Authority
CA
Canada
Prior art keywords
vitamin
hmb
hmbfa
formulation
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3105039A
Other languages
English (en)
French (fr)
Inventor
John Rathmacher
Martin PUPURA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Metabolic Technologies LLC
Original Assignee
Metabolic Technologies LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolic Technologies LLC filed Critical Metabolic Technologies LLC
Publication of CA3105039A1 publication Critical patent/CA3105039A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Mycology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Botany (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA3105039A 2019-06-25 2019-06-25 Stability of vitamin d in .beta.-hydroxy-.beta.-methylbutyrate (hmb) Pending CA3105039A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2019/038948 WO2020263229A1 (en) 2019-06-25 2019-06-25 STABILITY OF VITAMIN D IN β-HYDROXY- β-METHYLBUTYRATE (HMB)

Publications (1)

Publication Number Publication Date
CA3105039A1 true CA3105039A1 (en) 2020-12-30

Family

ID=74060572

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3105039A Pending CA3105039A1 (en) 2019-06-25 2019-06-25 Stability of vitamin d in .beta.-hydroxy-.beta.-methylbutyrate (hmb)

Country Status (7)

Country Link
JP (1) JP2022545299A (zh)
KR (1) KR20220050082A (zh)
CN (1) CN113056206A (zh)
AU (1) AU2019453386A1 (zh)
CA (1) CA3105039A1 (zh)
SG (1) SG11202012984YA (zh)
WO (1) WO2020263229A1 (zh)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6849613B2 (en) * 2001-08-29 2005-02-01 Kedar N. Prasad Multiple antioxidant micronutrients
US20060019933A1 (en) * 2004-07-22 2006-01-26 David Boardman Process for preparing stabilized vitamin D
US20100178369A1 (en) * 2009-01-15 2010-07-15 Nicole Lee Arledge Antioxidant-stabilized concentrated fish oil
SG192692A1 (en) * 2011-02-07 2013-09-30 Abbott Lab Nutritional products comprising beta-hydroxy-beta-methylbutyrate
CN102512655B (zh) * 2011-11-30 2013-10-30 北京康比特体育科技股份有限公司 左旋肉碱组合物和制剂，及其制备方法和应用
JP6480964B2 (ja) * 2014-03-14 2019-03-13 メタボリック・テクノロジーズ，インコーポレーテッド 遊離酸形のβ−ヒドロキシ−β−メチル酪酸（ＨＭＢ）を含有する液体及び食品ならびにその製造法
CN109862875A (zh) * 2016-03-30 2019-06-07 西姆莱斯股份公司 一种活性混合物

Also Published As

Publication number Publication date
AU2019453386A1 (en) 2021-02-18
JP2022545299A (ja) 2022-10-27
KR20220050082A (ko) 2022-04-22
WO2020263229A1 (en) 2020-12-30
SG11202012984YA (en) 2021-01-28
CN113056206A (zh) 2021-06-29

Similar Documents

Publication Publication Date Title
KR102100091B1 (ko) 영양 조성물
Kapoor et al. Coenzyme Q10-a novel molecule
JP4850986B2 (ja) カルノシンあるいはその誘導体および分枝アミノ酸を含む抗酸化活性を有する医薬組成物および／または栄養組成物
US20070292493A1 (en) Pharmaceutical composition and method for the transdermal delivery of calcium
US20070212448A1 (en) Total enteral nutritious composition
WO2007145239A1 (ja) アミノ酸組成物を含有する疲労防止剤
ZA200600203B (en) Multivitamin syrup for children or young adults
US10925845B2 (en) Stability of vitamin D in β-hydroxy-β-methylbutyrate (HMB)
US20150216779A1 (en) Compositions for targeted anti-aging therapy
US20050064014A1 (en) Use of cystathionine
US20070293572A1 (en) Anti-Fatigue Composition
US11490644B2 (en) Co-Q10, krill oil and vitamin D
CN115279209A (zh) 辅酶q产生促进剂和辅酶q产生促进方法
US20220040205A1 (en) Stability of vitamin d in beta-hydroxy- beta-methylbutyrate (hmb)
CA3105039A1 (en) Stability of vitamin d in .beta.-hydroxy-.beta.-methylbutyrate (hmb)
EP3836803A1 (en) Stability of vitamin d in beta-hydroxy- beta-methylbutyrate (hmb)
EP4110086A2 (en) Nutritional compositions for promoting pediatric health maintenance
US20210393559A1 (en) Compositions and Methods of Use of Beta-Hydroxy-Beta-methylbutyrate (HMB) for Improving Muscle Mass, Strength and Muscular Function Without Exercise
JP2000302677A (ja) カルニチン自己産生能改善作用を有する医薬および食品・飼料組成物