CA3098164A1 - Procede de preparation d'un intermediaire avance pour la synthese d'eribuline - Google Patents

Procede de preparation d'un intermediaire avance pour la synthese d'eribuline Download PDF

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Publication number
CA3098164A1
CA3098164A1 CA3098164A CA3098164A CA3098164A1 CA 3098164 A1 CA3098164 A1 CA 3098164A1 CA 3098164 A CA3098164 A CA 3098164A CA 3098164 A CA3098164 A CA 3098164A CA 3098164 A1 CA3098164 A1 CA 3098164A1
Authority
CA
Canada
Prior art keywords
compound
formula
converting
protecting group
parts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3098164A
Other languages
English (en)
Inventor
Jason BEXRUD
Alena Rudolph
Boris Gorin
Huimin ZHAI
Kiem Nguyen
Anne Luong
Dino Alberico
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eurofins CDMO Alphora Inc
Original Assignee
Eurofins CDMO Alphora Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eurofins CDMO Alphora Inc filed Critical Eurofins CDMO Alphora Inc
Priority to CA3098164A priority Critical patent/CA3098164A1/fr
Priority to PCT/CA2021/051567 priority patent/WO2022094711A1/fr
Publication of CA3098164A1 publication Critical patent/CA3098164A1/fr
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/207—Cyclohexane rings not substituted by nitrogen atoms, e.g. kasugamycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CA3098164A 2020-11-05 2020-11-05 Procede de preparation d'un intermediaire avance pour la synthese d'eribuline Pending CA3098164A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA3098164A CA3098164A1 (fr) 2020-11-05 2020-11-05 Procede de preparation d'un intermediaire avance pour la synthese d'eribuline
PCT/CA2021/051567 WO2022094711A1 (fr) 2020-11-05 2021-11-04 Procédé de préparation d'intermédiaire avancé pour la synthèse d'éribuline

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA3098164A CA3098164A1 (fr) 2020-11-05 2020-11-05 Procede de preparation d'un intermediaire avance pour la synthese d'eribuline

Publications (1)

Publication Number Publication Date
CA3098164A1 true CA3098164A1 (fr) 2022-05-05

Family

ID=81393264

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3098164A Pending CA3098164A1 (fr) 2020-11-05 2020-11-05 Procede de preparation d'un intermediaire avance pour la synthese d'eribuline

Country Status (2)

Country Link
CA (1) CA3098164A1 (fr)
WO (1) WO2022094711A1 (fr)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2522663T3 (pl) * 2004-06-03 2015-08-31 Eisai R&D Man Co Ltd Produkty pośrednie do otrzymywania halichondryny B
AR090699A1 (es) * 2012-04-18 2014-12-03 Biocryst Pharm Inc Compuestos inhibidores de la actividad de la arn polimerasa viral
CN110835353B (zh) * 2018-08-15 2022-08-19 上海茂晟康慧科技有限公司 一种艾日布林中间体er804698的合成方法

Also Published As

Publication number Publication date
WO2022094711A1 (fr) 2022-05-12

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