CA3082095A1 - A combination therapy with apatinib for the treatment of cancer - Google Patents
A combination therapy with apatinib for the treatment of cancer Download PDFInfo
- Publication number
- CA3082095A1 CA3082095A1 CA3082095A CA3082095A CA3082095A1 CA 3082095 A1 CA3082095 A1 CA 3082095A1 CA 3082095 A CA3082095 A CA 3082095A CA 3082095 A CA3082095 A CA 3082095A CA 3082095 A1 CA3082095 A1 CA 3082095A1
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- CA
- Canada
- Prior art keywords
- administered
- amount
- rivoceranib
- cancer
- nivolumab
- Prior art date
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- Pending
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Classifications
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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Landscapes
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- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762584547P | 2017-11-10 | 2017-11-10 | |
| US62/584,547 | 2017-11-10 | ||
| PCT/US2018/060179 WO2019094832A1 (en) | 2017-11-10 | 2018-11-09 | A combination therapy with apatinib for the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
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| CA3082095A1 true CA3082095A1 (en) | 2019-05-16 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3082095A Pending CA3082095A1 (en) | 2017-11-10 | 2018-11-09 | A combination therapy with apatinib for the treatment of cancer |
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| Country | Link |
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| US (1) | US20200282052A1 (enExample) |
| EP (1) | EP3706746A4 (enExample) |
| JP (2) | JP2021502415A (enExample) |
| KR (1) | KR20200107934A (enExample) |
| CA (1) | CA3082095A1 (enExample) |
| WO (1) | WO2019094832A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106176757B (zh) * | 2015-05-25 | 2019-12-10 | 江苏恒瑞医药股份有限公司 | 一种化合物与替吉奥联合在制备治疗增生性疾病中的药物中的用途 |
| WO2021047623A1 (en) * | 2019-09-11 | 2021-03-18 | Beigene, Ltd. | Treatment of cancer using a combination comprising multi-tyrosine kinase inhibitor and immune checkpoint inhibitor |
| CN112741905A (zh) * | 2019-10-30 | 2021-05-04 | 江苏恒瑞医药股份有限公司 | Vegfr抑制剂与抗pd-1抗体联合在制备治疗妊娠滋养细胞肿瘤的药物中的用途 |
| US20230181593A1 (en) * | 2020-05-21 | 2023-06-15 | The Regents Of The University Of California | Compositions and methods for treating breast cancer |
| CN111558044B (zh) * | 2020-06-01 | 2022-02-11 | 中山大学肿瘤防治中心(中山大学附属肿瘤医院、中山大学肿瘤研究所) | 一种包含舒尼替尼的药物组合物及其制剂和应用 |
| WO2024129903A1 (en) * | 2022-12-13 | 2024-06-20 | Elevar Therapeutics, Inc. | Pharmaceutical formulations of a tyrosine kinase inhibitor |
| WO2024130026A1 (en) * | 2022-12-16 | 2024-06-20 | Elevar Therapeutics, Inc. | Methods and compositions for treatment of subjects with hepatic impairments |
| WO2025024564A1 (en) * | 2023-07-24 | 2025-01-30 | The Board Of Regents Of The University Of Texas System | Small molecules that prevent statin-induced accumulation of hmg coa reductase |
| WO2025049528A1 (en) * | 2023-08-29 | 2025-03-06 | Cullinan Amber Corp. | Combination therapies for cancer |
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| CN101676267B (zh) * | 2008-09-16 | 2012-12-26 | 江苏恒瑞医药股份有限公司 | N-[4-(1-氰基环戊基)苯基]-2-(4-吡啶甲基)氨基-3-吡啶甲酰胺的盐 |
| BR112017004826A2 (pt) * | 2014-09-13 | 2017-12-12 | Novartis Ag | terapias de combinação de inibidores de alk |
| CA2978226C (en) * | 2015-03-04 | 2025-02-18 | Eisai R&D Management Co., Ltd. | COMBINATION OF A PD-1 ANTAGONIST AND A VEGFR/FGFR/RET TYROSINE KINASE INHIBITOR TO TREAT CANCER |
| CN106963948A (zh) * | 2017-05-12 | 2017-07-21 | 顾艳宏 | 阿帕替尼与Anti‑PD‑1抗体联用在制备结肠癌药物中的应用 |
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2018
- 2018-11-09 US US16/762,881 patent/US20200282052A1/en not_active Abandoned
- 2018-11-09 CA CA3082095A patent/CA3082095A1/en active Pending
- 2018-11-09 KR KR1020207016475A patent/KR20200107934A/ko not_active Ceased
- 2018-11-09 EP EP18876849.3A patent/EP3706746A4/en active Pending
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2024
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Also Published As
| Publication number | Publication date |
|---|---|
| EP3706746A4 (en) | 2021-12-15 |
| KR20200107934A (ko) | 2020-09-16 |
| JP2024095791A (ja) | 2024-07-10 |
| US20200282052A1 (en) | 2020-09-10 |
| JP2021502415A (ja) | 2021-01-28 |
| EP3706746A1 (en) | 2020-09-16 |
| WO2019094832A1 (en) | 2019-05-16 |
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