CA3081362C - Method of detecting the occurrence of adpkd based on presence of nucleotide sequence alteration in pkd1 - Google Patents
Method of detecting the occurrence of adpkd based on presence of nucleotide sequence alteration in pkd1 Download PDFInfo
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- CA3081362C CA3081362C CA3081362A CA3081362A CA3081362C CA 3081362 C CA3081362 C CA 3081362C CA 3081362 A CA3081362 A CA 3081362A CA 3081362 A CA3081362 A CA 3081362A CA 3081362 C CA3081362 C CA 3081362C
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- C—CHEMISTRY; METALLURGY
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
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| CA2658421A Active CA2658421C (en) | 2006-07-24 | 2007-07-24 | Pkd mutations and evaluation of same |
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| CA3081362C (en) | 2006-07-24 | 2024-04-09 | Athena Diagnostics, Inc. | Method of detecting the occurrence of adpkd based on presence of nucleotide sequence alteration in pkd1 |
| GB201410693D0 (en) | 2014-06-16 | 2014-07-30 | Univ Southampton | Splicing modulation |
| CN107109411B (zh) | 2014-10-03 | 2022-07-01 | 冷泉港实验室 | 核基因输出的定向增加 |
| KR20170081266A (ko) * | 2014-11-19 | 2017-07-11 | 오츠카 세이야쿠 가부시키가이샤 | Pkd1 유전자 및 pkd2 유전자의 엑손을 증폭시키기 위한 프라이머 세트 및 방법 |
| KR102422625B1 (ko) | 2015-10-09 | 2022-07-20 | 유니버시티 오브 사우스앰톤 | 유전자 발현의 조절 및 탈조절된 단백질 발현의 스크리닝 |
| US11096956B2 (en) | 2015-12-14 | 2021-08-24 | Stoke Therapeutics, Inc. | Antisense oligomers and uses thereof |
| KR102604132B1 (ko) | 2015-12-14 | 2023-11-17 | 콜드스프링하버러보러토리 | 상염색체 우성 정신 지체 5 및 드라베 증후군의 치료를 위한 안티센스 올리고머 |
| WO2017106211A1 (en) * | 2015-12-14 | 2017-06-22 | Cold Spring Harbor Laboratory | Antisense oligomers for treatment of polycystic kidney disease |
| CN111278991B (zh) | 2017-08-25 | 2022-04-01 | 斯托克制药公司 | 用于治疗病况和疾病的反义寡聚体 |
| US12060558B2 (en) | 2018-05-04 | 2024-08-13 | Stoke Therapeutics, Inc. | Methods and compositions for treatment of cholesteryl ester storage disease |
| CN115867657A (zh) | 2020-05-11 | 2023-03-28 | 斯托克制药公司 | 用于治疗疾患和疾病的opa1反义寡聚物 |
| CN115725716B (zh) * | 2022-09-20 | 2024-04-30 | 湖南家辉生物技术有限公司 | Pkd1致病突变基因及在制备多囊肾病诊断试剂盒中的应用 |
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| US6867288B1 (en) | 1994-10-12 | 2005-03-15 | Genzyme Corporation | Polycystic kidney disease gene |
| US6031088A (en) * | 1996-05-23 | 2000-02-29 | Albert Einstein College Of Medicine Of Yeshiva University | Polycystic kidney disease PKD2 gene and uses thereof |
| US6100386A (en) * | 1996-11-01 | 2000-08-08 | Cold Spring Harbor Laboratory | Human gene/protein involved in chronic myelogenous leukemia |
| CA2697031C (en) | 2000-07-13 | 2017-10-31 | The Johns Hopkins University School Of Medicine | Detection and treatment of polycystic kidney disease |
| US6916619B2 (en) * | 2001-10-12 | 2005-07-12 | Athena Diagnostics, Inc. | Compositions and methods for genetic analysis of polycystic kidney disease |
| US7273701B2 (en) * | 2001-10-12 | 2007-09-25 | Athena Diagnostics, Inc. | Compositions and methods for genetic analysis of polycystic kidney disease |
| CA2872385C (en) | 2003-04-11 | 2019-01-15 | Athena Diagnostics, Inc. | Compositions and methods for genetic analysis of polycystic kidney disease |
| CA3081362C (en) | 2006-07-24 | 2024-04-09 | Athena Diagnostics, Inc. | Method of detecting the occurrence of adpkd based on presence of nucleotide sequence alteration in pkd1 |
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| US20140349290A1 (en) | 2014-11-27 |
| JP2009544314A (ja) | 2009-12-17 |
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| WO2008094194A2 (en) | 2008-08-07 |
| US8771946B2 (en) | 2014-07-08 |
| US20100047785A1 (en) | 2010-02-25 |
| CA2658421C (en) | 2018-03-20 |
| US20210079472A1 (en) | 2021-03-18 |
| CA2658421A1 (en) | 2008-08-07 |
| WO2008094194A3 (en) | 2009-01-08 |
| US11655508B2 (en) | 2023-05-23 |
| US20230374593A1 (en) | 2023-11-23 |
| CA2993381A1 (en) | 2008-08-07 |
| CA3081362A1 (en) | 2008-08-07 |
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