CA3075784A1 - Methods for treating triple-negative breast cancer comprising a cdk19 inhibitory agent - Google Patents

Methods for treating triple-negative breast cancer comprising a cdk19 inhibitory agent Download PDF

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Publication number
CA3075784A1
CA3075784A1 CA3075784A CA3075784A CA3075784A1 CA 3075784 A1 CA3075784 A1 CA 3075784A1 CA 3075784 A CA3075784 A CA 3075784A CA 3075784 A CA3075784 A CA 3075784A CA 3075784 A1 CA3075784 A1 CA 3075784A1
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Prior art keywords
cdk19
cells
agent
cdk8
tumor
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CA3075784A
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English (en)
French (fr)
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CA3075784C (en
Inventor
Michael F. Clarke
Robert W. HSIEH
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Leland Stanford Junior University
CZ Biohub SF LLC
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Leland Stanford Junior University
Chan Zuckerberg Biohub Inc
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57415—Specifically defined cancers of breast

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CA3075784A 2017-09-18 2018-09-18 Methods for treating triple-negative breast cancer comprising a cdk19 inhibitory agent Active CA3075784C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762560140P 2017-09-18 2017-09-18
US62/560,140 2017-09-18
PCT/US2018/051489 WO2019055977A1 (en) 2017-09-18 2018-09-18 METHODS OF TREATING NEGATIVE TRIPLE BREAST CANCER

Publications (2)

Publication Number Publication Date
CA3075784A1 true CA3075784A1 (en) 2019-03-21
CA3075784C CA3075784C (en) 2025-11-25

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Also Published As

Publication number Publication date
WO2019055977A9 (en) 2019-04-25
CN111278469A (zh) 2020-06-12
EP3684420A4 (en) 2021-06-16
US20210121495A1 (en) 2021-04-29
AU2018333072A1 (en) 2020-03-26
JP2020534354A (ja) 2020-11-26
US11471477B2 (en) 2022-10-18
WO2019055977A1 (en) 2019-03-21
US20230285439A1 (en) 2023-09-14
AU2018333072B2 (en) 2022-09-29
EP3684420A1 (en) 2020-07-29
JP7392954B2 (ja) 2023-12-06

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