CA3073399A1 - Methods to improve organ viability - Google Patents

Methods to improve organ viability Download PDF

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Publication number
CA3073399A1
CA3073399A1 CA3073399A CA3073399A CA3073399A1 CA 3073399 A1 CA3073399 A1 CA 3073399A1 CA 3073399 A CA3073399 A CA 3073399A CA 3073399 A CA3073399 A CA 3073399A CA 3073399 A1 CA3073399 A1 CA 3073399A1
Authority
CA
Canada
Prior art keywords
organ
ppm
composition
gas
perfusion solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3073399A
Other languages
English (en)
French (fr)
Inventor
Jim POTENZIANO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Pharmaceuticals Ireland Ltd
Original Assignee
Mallinckrodt Hospital Products IP Unlimited Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Hospital Products IP Unlimited Co filed Critical Mallinckrodt Hospital Products IP Unlimited Co
Publication of CA3073399A1 publication Critical patent/CA3073399A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
    • A01N1/142—Apparatus
    • A01N1/143—Apparatus for organ perfusion
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00969—Surgical instruments, devices or methods used for transplantation

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
CA3073399A 2017-08-25 2018-08-24 Methods to improve organ viability Pending CA3073399A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762550463P 2017-08-25 2017-08-25
US62/550,463 2017-08-25
PCT/US2018/048028 WO2019040921A1 (en) 2017-08-25 2018-08-24 METHODS OF ENHANCING VIABILITY OF AN ORGAN

Publications (1)

Publication Number Publication Date
CA3073399A1 true CA3073399A1 (en) 2019-02-28

Family

ID=65434015

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3073399A Pending CA3073399A1 (en) 2017-08-25 2018-08-24 Methods to improve organ viability

Country Status (9)

Country Link
US (4) US11044904B2 (https=)
EP (1) EP3672403A4 (https=)
JP (4) JP7249331B2 (https=)
KR (2) KR20240142604A (https=)
CN (1) CN111107742A (https=)
AU (2) AU2018322317B2 (https=)
CA (1) CA3073399A1 (https=)
MX (1) MX2020001853A (https=)
WO (1) WO2019040921A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018013849A1 (en) * 2016-07-13 2018-01-18 The Trustees Of Columbia University In The City Of New York Cross-circulation platform for recovery, regeneration, and maintenance of extracorporeal organs
KR20240142604A (ko) * 2017-08-25 2024-09-30 말린크로트 파마슈티칼스 아일랜드 리미티드 기관 생존력을 개선시키는 방법
CN110583620A (zh) * 2019-08-26 2019-12-20 广东顺德工业设计研究院(广东顺德创新设计研究院) 离体肺脏机械灌注的调温设备及方法、装置
CN112106766B (zh) * 2020-11-18 2021-03-12 中山大学附属第一医院 一种离体心肺联合灌注系统及灌注方法
CN118142012B (zh) * 2024-03-20 2025-05-13 中国人民解放军总医院第四医学中心 离断肢体血液交叉循环系统

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5338662A (en) * 1992-09-21 1994-08-16 Bio-Preserve Medical Corporation Organ perfusion device
GB9908335D0 (en) * 1999-04-12 1999-06-09 Univ Cambridge Tech Methods and means for extracorporeal organ perfusion
US6811965B2 (en) * 2000-03-08 2004-11-02 Yoram Vodovotz Kidney perfusion solution containing nitric oxide donor, inhibitor of NOS2, glutathione, gluconate and methods of use
MXPA03012031A (es) * 2001-06-21 2005-07-01 Univ Yale El monoxido de carbono mejoraresultados en transplantes de tejido y organo y suprime apoptosis.
US7504201B2 (en) * 2004-04-05 2009-03-17 Organ Recovery Systems Method for perfusing an organ and for isolating cells from the organ
US20060160062A1 (en) * 2005-01-14 2006-07-20 Young Lindon H Perfusion and/or preservation solution for organs
JP4935242B2 (ja) 2006-08-24 2012-05-23 ニプロ株式会社 脂肪酸を含有するｓ−ニトロソタンパク質とその製法
EP2514473A1 (en) 2006-11-07 2012-10-24 The General Hospital Corporation Nitric oxide delivery device
WO2008157393A1 (en) * 2007-06-15 2008-12-24 Ikaria, Inc. Compositions comprising sulfide alone or in combination with nitric oxide and their use to
CA2819854A1 (en) 2010-12-03 2012-06-07 Geno Llc Nitric oxide treatments
US9629358B2 (en) 2013-03-15 2017-04-25 Mallinckrodt Hospital Products IP Limited Administration and monitoring of nitric oxide in ex vivo fluids
AU2016366698A1 (en) 2015-12-10 2018-06-28 Vero Biotech LLC Method and apparatus for scavenging plasma free hemoglobin
DE102017204681A1 (de) 2017-03-21 2018-09-27 Robert Bosch Gmbh Vorrichtung zum Auslösen einer externen Schutzfunktion
KR20240142604A (ko) * 2017-08-25 2024-09-30 말린크로트 파마슈티칼스 아일랜드 리미티드 기관 생존력을 개선시키는 방법

Also Published As

Publication number Publication date
JP2020531529A (ja) 2020-11-05
AU2018322317A1 (en) 2020-03-12
JP2022140622A (ja) 2022-09-26
US11950590B2 (en) 2024-04-09
CN111107742A (zh) 2020-05-05
MX2020001853A (es) 2020-08-03
KR20240142604A (ko) 2024-09-30
JP2024159817A (ja) 2024-11-08
AU2024200468A1 (en) 2024-02-15
JP7847618B2 (ja) 2026-04-17
AU2018322317B2 (en) 2023-11-23
US20190059359A1 (en) 2019-02-28
US11044904B2 (en) 2021-06-29
EP3672403A1 (en) 2020-07-01
US20210321605A1 (en) 2021-10-21
JP2025179164A (ja) 2025-12-09
EP3672403A4 (en) 2021-05-19
KR102708577B1 (ko) 2024-09-24
JP7249331B2 (ja) 2023-03-30
US12285008B2 (en) 2025-04-29
WO2019040921A1 (en) 2019-02-28
US20240138399A1 (en) 2024-05-02
AU2024200468B2 (en) 2026-01-29
US20250228235A1 (en) 2025-07-17
KR20200041359A (ko) 2020-04-21

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Downing et al. Acute physiological changes following heart-lung allotransplantation in dogs
Krueger et al. Ex vivo lung perfusion

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