CA3065086A1 - High affinity cxcr4 selective binding conjugate and method for using the same - Google Patents
High affinity cxcr4 selective binding conjugate and method for using the same Download PDFInfo
- Publication number
- CA3065086A1 CA3065086A1 CA3065086A CA3065086A CA3065086A1 CA 3065086 A1 CA3065086 A1 CA 3065086A1 CA 3065086 A CA3065086 A CA 3065086A CA 3065086 A CA3065086 A CA 3065086A CA 3065086 A1 CA3065086 A1 CA 3065086A1
- Authority
- CA
- Canada
- Prior art keywords
- ipr
- high affinity
- selective binding
- binding ligand
- peptide conjugate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
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- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
Landscapes
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- Chemical & Material Sciences (AREA)
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- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US201762554354P | 2017-09-05 | 2017-09-05 | |
| US62/554,354 | 2017-09-05 | ||
| PCT/US2018/018530 WO2019050564A1 (en) | 2017-09-05 | 2018-02-17 | CXCR4 SELECTIVE BINDING CONJUGATE WITH HIGH AFFINITY AND METHOD OF USING THE SAME |
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| CA3065086A1 true CA3065086A1 (en) | 2019-03-14 |
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| JP (1) | JP2020532496A (enrdf_load_stackoverflow) |
| KR (2) | KR20200043970A (enrdf_load_stackoverflow) |
| CN (1) | CN111183146A (enrdf_load_stackoverflow) |
| CA (1) | CA3065086A1 (enrdf_load_stackoverflow) |
| WO (1) | WO2019050564A1 (enrdf_load_stackoverflow) |
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| US11123437B2 (en) | 2017-09-05 | 2021-09-21 | Mainline Biosciences, Inc. | Selective CXCR4 binding peptide conjugate and methods for making and using the same |
| JP2021165234A (ja) * | 2018-07-03 | 2021-10-14 | 富士フイルム富山化学株式会社 | Ｃｘｃｒ４結合性化合物もしくはその塩またはそれらと金属との錯体 |
| JP7541532B2 (ja) | 2019-04-18 | 2024-08-28 | プロビンシャル・ヘルス・サービシーズ・オーソリティ | 診断及び治療のための新規な放射性標識されたｃｘｃｒ４を標的とする化合物 |
| JP2023516878A (ja) * | 2020-01-26 | 2023-04-21 | メインライン バイオサイエンシーズ（シャンハイ）シーオー．，エルティーディ． | 同位体標識された選択的ｃｘｃｒ４結合性ペプチドコンジュゲート並びにその作製方法及び使用方法 |
| AU2023218802A1 (en) * | 2022-02-11 | 2023-11-09 | C-Biomex Co., Ltd. | Peptide ligand targeting carbonic anhydrase ix, peptide construct comprising same, and uses thereof |
| CN114832113B (zh) * | 2022-03-22 | 2023-06-20 | 重庆医科大学 | 疏水药物-马来酰亚胺衍生物及其主动载药脂质体和应用 |
| WO2023201435A1 (en) * | 2022-04-20 | 2023-10-26 | Provincial Health Services Authority | Cxcr4-targeting compounds, and methods of making and using the same |
| CN116023438B (zh) * | 2023-02-06 | 2025-07-11 | 中国药科大学 | 一种cxcr4靶向多肽及其应用 |
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| EP1991562A2 (en) * | 2006-02-27 | 2008-11-19 | Technische Universität München | Cancer imaging and treatment |
| PT2160221E (pt) * | 2007-05-30 | 2011-09-12 | Lilly Co Eli | Péptidos cíclicos antagonistas de cxcr4 |
| IT1397901B1 (it) * | 2010-01-26 | 2013-02-04 | Consiglio Nazionale Ricerche | Peptidi ciclici che legano il recettore cxcr4 e relativi usi in campo medico e diagnostico. |
| CN102626522B (zh) * | 2012-04-12 | 2014-09-10 | 韩彦江 | 基于趋化因子受体cxcr4多肽类拮抗剂的多肽放射性诊断与治疗药物 |
| AU2012381808B2 (en) * | 2012-06-06 | 2017-04-27 | Polyphor Ag | Beta-hairpin peptidomimetics |
| US9790286B2 (en) * | 2013-01-02 | 2017-10-17 | Lucia Irene Gonzalez | Stereoisomer peptides, their polymer conjugates, their encapsulation into nanoparticles, and uses thereof for the treatment of diseases caused by abnormal angiogenesis |
| AU2014396468B2 (en) * | 2014-06-06 | 2019-02-21 | Technische Universitat Munchen | Modified cyclopentapeptides and uses thereof |
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- 2018-02-17 KR KR1020207000227A patent/KR20200043970A/ko not_active Ceased
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- 2018-02-17 WO PCT/US2018/018530 patent/WO2019050564A1/en unknown
- 2018-02-17 CN CN201880049498.7A patent/CN111183146A/zh active Pending
- 2018-02-17 CA CA3065086A patent/CA3065086A1/en active Pending
- 2018-02-17 KR KR1020237034343A patent/KR20230145543A/ko not_active Ceased
Also Published As
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| EP3679053A1 (en) | 2020-07-15 |
| WO2019050564A1 (en) | 2019-03-14 |
| KR20200043970A (ko) | 2020-04-28 |
| CN111183146A (zh) | 2020-05-19 |
| JP2020532496A (ja) | 2020-11-12 |
| EP3679053A4 (en) | 2021-10-27 |
| KR20230145543A (ko) | 2023-10-17 |
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