CA3052704A1 - Materials and methods for delivering nucleic acids to cochlear and vestibular cells - Google Patents
Materials and methods for delivering nucleic acids to cochlear and vestibular cells Download PDFInfo
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- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
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| EP3510161A4 (en) | 2016-08-23 | 2020-04-22 | Akouos, Inc. | COMPOSITIONS AND METHODS FOR TREATING NON-AGE-ASSOCIATED HEARING DEFICIENCY IN A HUMAN SUBJECT |
| DE102018103924A1 (de) * | 2018-02-21 | 2019-08-22 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | Gentherapeutische Behandlung von Schwerhörigkeit |
| JP7430652B2 (ja) | 2018-03-05 | 2024-02-13 | ザ チルドレンズ メディカル センター コーポレーション | 蝸牛および前庭細胞に核酸を送達するための組成物および方法 |
| US11660353B2 (en) | 2018-04-27 | 2023-05-30 | Decibel Therapeutics, Inc. | Compositions and methods for treating sensorineural hearing loss using otoferlin dual vector systems |
| JP7331011B2 (ja) | 2018-04-27 | 2023-08-22 | デシベル セラピューティクス インコーポレイテッド | ミオシン１５プロモーター及びその使用 |
| EP3856227A4 (en) * | 2018-09-27 | 2022-07-06 | Akouos, Inc. | A method for treating an auditory neuropathy spectrum disorder |
| US20220096658A1 (en) * | 2018-12-21 | 2022-03-31 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Svcs. | Adeno-associated viruses and their uses for inner ear therapy |
| WO2020163743A1 (en) | 2019-02-08 | 2020-08-13 | Decibel Therapeutics, Inc. | Compositions and methods for treating sensorineural hearing loss using otoferlin dual vector systems |
| CA3129422A1 (en) | 2019-02-08 | 2020-08-13 | Decibel Therapeutics, Inc. | Myosin 15 promoters and uses thereof |
| EP3959324B1 (en) * | 2019-04-26 | 2025-09-17 | President and Fellows of Harvard College | Aav vectors encoding mini-pcdh15 and uses thereof |
| US20220396806A1 (en) * | 2019-07-26 | 2022-12-15 | Akouos, Inc. | Methods of treating hearing loss using a secreted target protein |
| EP4055175A4 (en) * | 2019-11-04 | 2023-11-29 | Decibel Therapeutics, Inc. | Cochlear inner hair cell promoters and uses thereof |
| WO2021091950A1 (en) * | 2019-11-04 | 2021-05-14 | Decibel Therapeutics, Inc. | Vestibular supporting cell promoters and uses thereof |
| CN113840915A (zh) * | 2020-01-24 | 2021-12-24 | 美利坚合众国, 由健康及人类服务部部长代表 | 腺相关病毒及其用于内耳疗法的用途 |
| WO2021168362A1 (en) | 2020-02-21 | 2021-08-26 | Akouos, Inc. | Compositions and methods for treating non-age-associated hearing impairment in a human subject |
| WO2022129543A1 (en) * | 2020-12-18 | 2022-06-23 | Institut Pasteur | Gene therapy for treating usher syndrome |
| CN114762733B (zh) * | 2021-01-15 | 2025-03-18 | 中国科学院脑科学与智能技术卓越创新中心 | 耳蜗外毛细胞特异性顺式调节元件及其应用 |
| KR102751019B1 (ko) * | 2021-03-03 | 2025-01-09 | 연세대학교 산학협력단 | Kcnq4 유전자 교정용 가이드 rna 및 이를 포함하는 난청 치료용 조성물 |
| US20250114480A1 (en) | 2022-01-25 | 2025-04-10 | Bridgebio Gene Therapy Research, Inc. | Gene therapy for genetic hearing loss |
| WO2024239226A1 (zh) * | 2023-05-23 | 2024-11-28 | 苏州星奥拓维生物技术有限公司 | 耳蜗毛细胞特异性启动子及其用途 |
| CN119061007A (zh) * | 2023-06-02 | 2024-12-03 | 苏州星奥拓维生物技术有限公司 | 耳蜗支持细胞基因治疗和再生的方法 |
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| US8673634B2 (en) * | 2003-11-13 | 2014-03-18 | Massachusetts Eye & Ear Infirmary | Method for the treatment of hearing loss |
| WO2011075838A1 (en) | 2009-12-21 | 2011-06-30 | Audigen Inc. | Method of treating or preventing hearing loss |
| KR100990160B1 (ko) * | 2010-03-15 | 2010-10-29 | 도태환 | 기전력 안정화 영구자석 발전기 |
| JP6552511B2 (ja) * | 2013-10-11 | 2019-07-31 | マサチューセッツ アイ アンド イヤー インファーマリー | 祖先ウイルス配列を予測する方法およびその使用 |
| BR112016013201B1 (pt) * | 2013-12-12 | 2023-01-31 | The Broad Institute, Inc. | Uso de uma composição compreendendo um sistema crispr-cas no tratamento de uma doença genética ocular |
| JP6990182B2 (ja) * | 2015-12-11 | 2022-02-15 | マサチューセッツ アイ アンド イヤー インファーマリー | 蝸牛および前庭細胞に核酸を送達するための材料および方法 |
| US20190038778A1 (en) | 2016-02-05 | 2019-02-07 | The General Hospital Corporation | Hybrid System for Efficient Gene Delivery to Cells of the Inner Ear |
| WO2018017834A1 (en) * | 2016-07-21 | 2018-01-25 | The Regents Of The University Of California | Methods for inducing stereocilia on hair cells |
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| EP3576696A1 (en) | 2019-12-11 |
| US20230330268A1 (en) | 2023-10-19 |
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| JP2023036921A (ja) | 2023-03-14 |
| JP2020508648A (ja) | 2020-03-26 |
| JP7601916B2 (ja) | 2024-12-17 |
| US11730827B2 (en) | 2023-08-22 |
| AU2018215785A1 (en) | 2019-08-22 |
| US20190351072A1 (en) | 2019-11-21 |
| AU2018215785A9 (en) | 2019-09-26 |
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