CA3036820A1 - Genome edited primary b cell and methods of making and using - Google Patents

Genome edited primary b cell and methods of making and using Download PDF

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Publication number
CA3036820A1
CA3036820A1 CA3036820A CA3036820A CA3036820A1 CA 3036820 A1 CA3036820 A1 CA 3036820A1 CA 3036820 A CA3036820 A CA 3036820A CA 3036820 A CA3036820 A CA 3036820A CA 3036820 A1 CA3036820 A1 CA 3036820A1
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Prior art keywords
cell
primary
genome
nucleic acid
edited
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CA3036820A
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English (en)
French (fr)
Inventor
Branden S. Moriarity
John HUNZEKER
Matthew Johnson
Kanut LAOHARAWEE
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University of Minnesota Twin Cities
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University of Minnesota Twin Cities
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Publication of CA3036820A1 publication Critical patent/CA3036820A1/en
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/00—Cellular immunotherapy
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N2310/00—Structure or type of the nucleic acid
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CA3036820A 2016-09-12 2017-09-12 Genome edited primary b cell and methods of making and using Pending CA3036820A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662393512P 2016-09-12 2016-09-12
US62/393,512 2016-09-12
PCT/US2017/051182 WO2018049401A1 (en) 2016-09-12 2017-09-12 Genome edited primary b cell and methods of making and using

Publications (1)

Publication Number Publication Date
CA3036820A1 true CA3036820A1 (en) 2018-03-15

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ID=61562180

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CA3036820A Pending CA3036820A1 (en) 2016-09-12 2017-09-12 Genome edited primary b cell and methods of making and using

Country Status (7)

Country Link
US (1) US20220168342A1 (enExample)
EP (1) EP3509606A4 (enExample)
JP (2) JP2019526270A (enExample)
CN (1) CN109843303A (enExample)
AU (1) AU2017322733B2 (enExample)
CA (1) CA3036820A1 (enExample)
WO (1) WO2018049401A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2018235957B2 (en) 2017-03-16 2024-02-01 Seattle Children's Hospital (dba Seattle Children's Research Institute) Engraftable cell-based immunotherapy for long-term delivery of therapeutic proteins
AU2020392222A1 (en) * 2019-11-27 2022-06-09 Board Of Regents, The University Of Texas System Large-scale combined CAR transduction and CRISPR gene editing of B cells
WO2023283585A2 (en) * 2021-07-06 2023-01-12 Vor Biopharma Inc. Inhibitor oligonucleotides and methods of use thereof
WO2023010125A1 (en) * 2021-07-29 2023-02-02 Regents Of The University Of Minnesota Multiplex base editing of primary human natural killer cells
EP4555091A2 (en) * 2022-07-13 2025-05-21 Vor Biopharma Inc. Compositions and methods for artificial protospacer adjacent motif (pam) generation
WO2024196669A2 (en) * 2023-03-17 2024-09-26 Walking Fish Therapeutics, Inc. Methods for in vivo editing of b cells

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170354681A1 (en) * 2014-10-24 2017-12-14 Bcrt Holding Bv T cell-based immunotherapeutics
EP4177336A1 (en) * 2014-12-19 2023-05-10 Immusoft Corporation B cells for in vivo delivery of therapeutic agents
EP4335918A3 (en) * 2015-04-03 2024-04-17 Dana-Farber Cancer Institute, Inc. Composition and methods of genome editing of b-cells

Also Published As

Publication number Publication date
JP2019526270A (ja) 2019-09-19
WO2018049401A8 (en) 2019-04-04
US20220168342A1 (en) 2022-06-02
EP3509606A1 (en) 2019-07-17
CN109843303A (zh) 2019-06-04
JP2022189863A (ja) 2022-12-22
AU2017322733B2 (en) 2024-05-09
EP3509606A4 (en) 2020-10-07
WO2018049401A1 (en) 2018-03-15
AU2017322733A1 (en) 2019-04-11

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