CA3035931A1 - Cell expansion methods and therapeutic compositions - Google Patents

Cell expansion methods and therapeutic compositions Download PDF

Info

Publication number
CA3035931A1
CA3035931A1 CA3035931A CA3035931A CA3035931A1 CA 3035931 A1 CA3035931 A1 CA 3035931A1 CA 3035931 A CA3035931 A CA 3035931A CA 3035931 A CA3035931 A CA 3035931A CA 3035931 A1 CA3035931 A1 CA 3035931A1
Authority
CA
Canada
Prior art keywords
mscs
cells
culture
media
conditioned media
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3035931A
Other languages
English (en)
French (fr)
Inventor
Balarka BANERJEE
Charlotte Morgan
Graham Vesey
Nicolle Hannah Packer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cell Ideas Pty Ltd
Original Assignee
Cell Ideas Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2015903658A external-priority patent/AU2015903658A0/en
Application filed by Cell Ideas Pty Ltd filed Critical Cell Ideas Pty Ltd
Publication of CA3035931A1 publication Critical patent/CA3035931A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA3035931A 2015-09-08 2016-09-08 Cell expansion methods and therapeutic compositions Pending CA3035931A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2015903658 2015-09-08
AU2015903658A AU2015903658A0 (en) 2015-09-08 Cell expansion methods and therapeutic compositions
PCT/AU2016/000316 WO2017041133A1 (en) 2015-09-08 2016-09-08 Cell expansion methods and therapeutic compositions

Publications (1)

Publication Number Publication Date
CA3035931A1 true CA3035931A1 (en) 2017-03-16

Family

ID=58240422

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3035931A Pending CA3035931A1 (en) 2015-09-08 2016-09-08 Cell expansion methods and therapeutic compositions

Country Status (10)

Country Link
US (2) US20180236003A1 (https=)
EP (1) EP3347449A4 (https=)
JP (3) JP6995752B2 (https=)
KR (1) KR20180043834A (https=)
CN (1) CN108348555B (https=)
AU (1) AU2016321448B2 (https=)
CA (1) CA3035931A1 (https=)
HK (1) HK1252778A1 (https=)
TW (1) TWI760313B (https=)
WO (1) WO2017041133A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018531269A (ja) * 2015-10-23 2018-10-25 リグスホスピタレットＲｉｇｓｈｏｓｐｉｔａｌｅｔ 脂肪由来幹細胞に基づく幹細胞治療
WO2018213795A1 (en) * 2017-05-18 2018-11-22 The Board Of Trustees Of The Leland Stanford Junior University Targeted in situ therapeutic delivery of secreted factors from stem cells for treatment of damaged tissue
MA52883A (fr) 2018-06-15 2021-05-26 Prieto Manuel Hermida Composition pharmaceutique pour dermatologie et ses utilisations
CN109022360A (zh) * 2018-07-03 2018-12-18 湖南未名三胞转化医学科技有限公司 自体脂肪干细胞共培养促进外周血造血干细胞增殖方法
CN110106142B (zh) * 2019-05-30 2020-05-12 深圳阿尔法生物科技有限公司 一种制备“百亿”级脂肪源再生细胞的生产工艺
CN111073857A (zh) * 2019-12-30 2020-04-28 深圳爱生再生医学科技有限公司 一种治疗关节炎的干细胞生物制品及其制备方法与应用
KR102193175B1 (ko) 2020-04-07 2020-12-18 주식회사 엑소스템텍 통증조절인자를 함유한 줄기세포유래 엑소좀 및 그 용도
CO2020012570A1 (es) 2020-10-08 2022-04-08 Inst Distrital De Ciencia Biotecnologia E Innovacion En Salud Idcbis Método de estimulación de células mesenquimales para inducir expresión de factores inmunomoduladores
US20230365937A1 (en) * 2020-10-26 2023-11-16 Hadasit Medical Research Services And Development Ltd. Mesenchymal stem cells and their culture
WO2022192429A1 (en) * 2021-03-10 2022-09-15 Terasaki Insutitute For Biomedical Innovation Constructs comprising fibrin or other blood products for meat cultivation and other applications
BR102022016233A2 (pt) * 2022-08-16 2024-02-27 Omics Biotecnologia Animal Ltda Concentrado de proteínas e peptídeos derivados de células estromais mesenquimais, método de obtenção e uso de concentrado

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0404656D0 (en) * 2004-03-02 2004-04-07 Univ Manchester Treatment of spinal conditions
WO2008034803A1 (en) * 2006-09-18 2008-03-27 Medizinische Universität Graz Plasma-free platelet lysate for use as a supplement in cell cultures and for the preparation of cell therapeutics
WO2012030968A1 (en) * 2010-08-31 2012-03-08 Renovocyte, LLC Systemic, allogenic stem cell therapies for treatment of diseases in animals
DK2744892T3 (en) 2011-09-23 2019-04-23 Cell Ideas Pty Ltd THERAPEUTICS USING FAT CELLS AND CELL SECRETIONS
US20140219972A1 (en) 2013-02-05 2014-08-07 The Board Of Trustees Of The Leland Stanford Junior University Tissue engineering using progenitor cells to catalyze tissue formation by primary cells
EP3405204B1 (en) * 2016-08-26 2025-06-25 Restem Llc Composition and methods of using umbilical cord lining stem cells

Also Published As

Publication number Publication date
US20180236003A1 (en) 2018-08-23
WO2017041133A1 (en) 2017-03-16
AU2016321448B2 (en) 2023-02-02
EP3347449A4 (en) 2019-03-20
TW201720922A (zh) 2017-06-16
TWI760313B (zh) 2022-04-11
KR20180043834A (ko) 2018-04-30
JP6995752B2 (ja) 2022-02-04
US20210260129A1 (en) 2021-08-26
CN108348555A (zh) 2018-07-31
JP2022186992A (ja) 2022-12-15
JP2022027928A (ja) 2022-02-14
EP3347449A1 (en) 2018-07-18
CN108348555B (zh) 2022-07-08
AU2016321448A1 (en) 2018-03-15
HK1252778A1 (zh) 2019-05-31
JP2018526447A (ja) 2018-09-13

Similar Documents

Publication Publication Date Title
US20210260129A1 (en) Cell Expansion Methods and Therapeutic Compositions
Al Naem et al. Therapeutic mesenchymal stromal stem cells: Isolation, characterization and role in equine regenerative medicine and metabolic disorders
KR20090117817A (ko) 자궁내막/월경 세포의 획득, 분리와 동결보존
WO2011069121A1 (en) Mesenchymal stem cells (mscs) isolated from mobilized peripheral blood
AU2019348047B2 (en) Mesenchymal stem cells and products therefrom
JP2010529987A5 (https=)
KR20100035648A (ko) 체외 배양 및 증식 자기재생성 집락 형성 세포를 이용한 질환 및 장애 치료방법
Iacono et al. Equine bone marrow and adipose tissue mesenchymal stem cells: cytofluorimetric characterization, in vitro differentiation, and clinical application
CN108685948A (zh) 一种新型医用细胞修复剂的制备方法
Bohlouli et al. Tissue buccal fat pad–stromal vascular fraction as a safe source in maxillofacial bone regeneration: A clinical pilot study
Tong et al. Umbilical cord blood-derived platelet-rich plasma as a coating substrate supporting cell adhesion and biological activities of wound healing
US20180000869A1 (en) Amniotic fluid-derived preparations
CN114341346B (zh) 用于治疗骨关节炎的治疗性凋亡细胞
US20230346842A1 (en) Methods and Compositions For Reducing Joint Inflammation Using Mesenchymal Stem Cells
WO2021011779A2 (en) Mesenchymal stem cell compositions
Pieper et al. Isolation of mesenchymal stromal cells from peripheral blood of ST elevation myocardial infarction patients
KR20240034745A (ko) 동물의 골관절염 치료용 중간엽 줄기세포
WO2011145110A1 (en) A novel cord blood plasma nutrient formulation and a method for the preparation thereof
EP4227406A1 (en) Method for stimulation of mesenchymal cells to induce immunomodulatory factor expression
KR102190231B1 (ko) 조직 유래 침지액 및 이를 포함하는 세포 배양용 배지 조성물
Williams Effects of Cryopreservation, Immunophenotype and Sex on Multipotentiality, Cell Proliferation and Gene Expression in Feline Adipose-Derived Stromal Cells
WO2024246778A1 (en) Method for obtaining an advanced cell therapy product by means of the culture of mesenchymal stem cells conditioned with hyaluronic acid and sulfated derivatives, for bone injuries
Wang et al. Selection of basal medium for culturing human umbilical cord mesenchymal stem cells in combination with human platelet lysate
CN121285620A (zh) 间充质干细胞来源的含有外泌体的液的生产方法及含含有外泌体的液的药品
WO2024133886A1 (en) Primed mesenchymal stem cells for use in the treatment of chronic kidney disease

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20210908