CA3030959A1 - Method for providing tumour-specific t cells - Google Patents
Method for providing tumour-specific t cells Download PDFInfo
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- CA3030959A1 CA3030959A1 CA3030959A CA3030959A CA3030959A1 CA 3030959 A1 CA3030959 A1 CA 3030959A1 CA 3030959 A CA3030959 A CA 3030959A CA 3030959 A CA3030959 A CA 3030959A CA 3030959 A1 CA3030959 A1 CA 3030959A1
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- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/32—T-cell receptors [TCR]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/428—Undefined tumor antigens, e.g. tumor lysate or antigens targeted by cells isolated from tumor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57423—Specifically defined cancers of lung
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/55—Lung
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
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- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Biophysics (AREA)
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- Veterinary Medicine (AREA)
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- Animal Behavior & Ethology (AREA)
- Analytical Chemistry (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15180383 | 2015-08-10 | ||
| EP15180383.0 | 2015-08-10 | ||
| EP15202419.6 | 2015-12-23 | ||
| EP15202419 | 2015-12-23 | ||
| PCT/EP2016/069041 WO2017025564A1 (en) | 2015-08-10 | 2016-08-10 | Method for providing tumour-specific t cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3030959A1 true CA3030959A1 (en) | 2017-02-16 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3030959A Pending CA3030959A1 (en) | 2015-08-10 | 2016-08-10 | Method for providing tumour-specific t cells |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20190255162A1 (enExample) |
| EP (2) | EP3372683B1 (enExample) |
| JP (1) | JP6815400B2 (enExample) |
| CA (1) | CA3030959A1 (enExample) |
| DK (2) | DK3180433T3 (enExample) |
| ES (2) | ES2807026T3 (enExample) |
| WO (1) | WO2017025564A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220112557A1 (en) * | 2019-01-10 | 2022-04-14 | Iovance Biotherapeutics, Inc. | System and methods for monitoring adoptive cell therapy clonality and persistence |
| CA3225111A1 (en) | 2021-07-15 | 2023-02-02 | Rudolf Hammer | Identification of common tumor-specific t cell receptors and antigens |
| EP4426320A4 (en) * | 2021-11-03 | 2025-11-05 | Univ Delaware | SYSTEM FOR ADMINISTRATING CELL-DERIVED MICROPARTICLES AND ITS USES |
| CN114530202A (zh) * | 2021-12-20 | 2022-05-24 | 深圳泛因医学有限公司 | 鉴定抗原特异性tcr或bcr的方法及应用 |
| US20250368717A1 (en) | 2022-05-30 | 2025-12-04 | Hs Diagnomics Gmbh | Common tumor-specific t cell receptors |
| EP4649952A1 (en) | 2024-05-14 | 2025-11-19 | HS Diagnomics GmbH | Kras q16h specific t cell receptors and uses thereof |
| WO2025238079A1 (en) | 2024-05-14 | 2025-11-20 | Hs Diagnomics Gmbh | Kras q16h specific t cell receptors and uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| GB0128153D0 (en) * | 2001-11-23 | 2002-01-16 | Bayer Ag | Profiling of the immune gene repertoire |
| DE102004063339A1 (de) | 2004-12-23 | 2006-07-06 | Bayer Technology Services Gmbh | Sonde zum Nachweis von Nukleinsäuren |
| EP2980225B1 (en) * | 2012-04-20 | 2017-11-08 | Alacris Theranostics GmbH | Cdr sequence-specific enrichment of live immune cells |
| EP2746405B1 (en) | 2012-12-23 | 2015-11-04 | HS Diagnomics GmbH | Methods and primer sets for high throughput PCR sequencing |
| JP6164759B2 (ja) * | 2013-11-21 | 2017-07-19 | Ｒｅｐｅｒｔｏｉｒｅ Ｇｅｎｅｓｉｓ株式会社 | Ｔ細胞受容体およびｂ細胞受容体レパトアの解析システムならびにその治療および診断への利用 |
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2016
- 2016-08-10 EP EP18167345.0A patent/EP3372683B1/en active Active
- 2016-08-10 EP EP16753630.9A patent/EP3180433B1/en active Active
- 2016-08-10 CA CA3030959A patent/CA3030959A1/en active Pending
- 2016-08-10 DK DK16753630.9T patent/DK3180433T3/en active
- 2016-08-10 DK DK18167345.0T patent/DK3372683T3/da active
- 2016-08-10 JP JP2018527008A patent/JP6815400B2/ja active Active
- 2016-08-10 WO PCT/EP2016/069041 patent/WO2017025564A1/en not_active Ceased
- 2016-08-10 US US15/751,883 patent/US20190255162A1/en not_active Abandoned
- 2016-08-10 ES ES18167345T patent/ES2807026T3/es active Active
- 2016-08-10 ES ES16753630.9T patent/ES2679798T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| DK3372683T3 (da) | 2020-07-27 |
| ES2679798T3 (es) | 2018-08-31 |
| JP2018525034A (ja) | 2018-09-06 |
| DK3180433T3 (en) | 2018-07-30 |
| ES2807026T3 (es) | 2021-02-19 |
| WO2017025564A1 (en) | 2017-02-16 |
| EP3372683B1 (en) | 2020-05-27 |
| EP3372683A1 (en) | 2018-09-12 |
| EP3180433A1 (en) | 2017-06-21 |
| US20190255162A1 (en) | 2019-08-22 |
| EP3180433B1 (en) | 2018-04-18 |
| JP6815400B2 (ja) | 2021-01-20 |
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