CA3030872A1 - Traitement de la demence fronto-temporale. - Google Patents

Traitement de la demence fronto-temporale. Download PDF

Info

Publication number
CA3030872A1
CA3030872A1 CA3030872A CA3030872A CA3030872A1 CA 3030872 A1 CA3030872 A1 CA 3030872A1 CA 3030872 A CA3030872 A CA 3030872A CA 3030872 A CA3030872 A CA 3030872A CA 3030872 A1 CA3030872 A1 CA 3030872A1
Authority
CA
Canada
Prior art keywords
antibody
seq
amino acid
binding
complement
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA3030872A
Other languages
English (en)
Inventor
Sethu SANKARANARAYANAN
Ted Yednock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Annexon Inc
Original Assignee
Annexon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Annexon Inc filed Critical Annexon Inc
Publication of CA3030872A1 publication Critical patent/CA3030872A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2814Dementia; Cognitive disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention porte sur des méthodes de prévention, de réduction du risque de développement ou de traitement de la démence fronto-temporale (DFT) ou d'une variante de celle-ci, par l'administration d'un inhibiteur de la voie du complément.
CA3030872A 2016-07-19 2017-07-19 Traitement de la demence fronto-temporale. Abandoned CA3030872A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662364013P 2016-07-19 2016-07-19
US62/364,013 2016-07-19
PCT/US2017/042846 WO2018017711A1 (fr) 2016-07-19 2017-07-19 Traitement de la démence fronto-temporale.

Publications (1)

Publication Number Publication Date
CA3030872A1 true CA3030872A1 (fr) 2018-01-25

Family

ID=60992917

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3030872A Abandoned CA3030872A1 (fr) 2016-07-19 2017-07-19 Traitement de la demence fronto-temporale.

Country Status (6)

Country Link
EP (1) EP3487531A4 (fr)
AU (1) AU2017299579A1 (fr)
CA (1) CA3030872A1 (fr)
IL (1) IL264167A (fr)
SG (1) SG11201900123TA (fr)
WO (1) WO2018017711A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2916521C (fr) 2013-07-09 2023-03-07 Annexon, Inc. Anticorps anti-facteur du complement c1q et utilisations de ceux-ci
BR112018010360A2 (pt) * 2015-11-24 2018-12-04 Annexon Inc fragmentos fab de fator de complemento anti-c1q e utilizações dos mesmos
CN108159421B (zh) * 2018-02-05 2021-05-18 苏州大学 磷脂酰丝氨酸阻断剂在制备治疗血小板数量减少相关疾病药物中的用途
JP7499760B2 (ja) * 2018-11-02 2024-06-14 アネクソン,インコーポレーテッド 脳損傷を治療するための組成物及び方法
CN115996752A (zh) * 2020-05-05 2023-04-21 J·大卫格莱斯顿研究所-根据J·大卫格莱斯顿遗嘱的遗嘱信托 用于治疗癫痫的组合物和方法
TW202216760A (zh) 2020-07-23 2022-05-01 愛爾蘭商歐薩爾普羅席納有限公司 抗類澱粉β (ABETA)抗體
US11958899B2 (en) 2021-07-13 2024-04-16 Mabwell Therapeutics Inc. Anti-C1s antibodies and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9480658B2 (en) * 2005-12-09 2016-11-01 The Board Of Trustees Of The Leland Stanford Junior University Modulation of synaptic maintenance
WO2007070375A2 (fr) * 2005-12-09 2007-06-21 The Board Of Trustees Of The Leland Stanford Junior University Modulation du maitien synaptique
JP6538561B2 (ja) * 2012-10-25 2019-07-03 バイオベラティブ・ユーエスエイ・インコーポレイテッド 抗補体C1s抗体とそれらの用途
CA2916521C (fr) * 2013-07-09 2023-03-07 Annexon, Inc. Anticorps anti-facteur du complement c1q et utilisations de ceux-ci
EP4295911A3 (fr) * 2014-11-05 2024-03-27 Annexon, Inc. Anticorps humanisés anti-facteur du compément c1q et leurs utilisations

Also Published As

Publication number Publication date
AU2017299579A1 (en) 2019-01-24
EP3487531A1 (fr) 2019-05-29
IL264167A (en) 2019-02-28
SG11201900123TA (en) 2019-02-27
EP3487531A4 (fr) 2020-03-25
WO2018017711A1 (fr) 2018-01-25

Similar Documents

Publication Publication Date Title
US11999779B2 (en) Anti-complement factor C1q Fab fragments and uses thereof
CN108431041B (zh) 抗siglec-9抗体及其使用方法
CA3030872A1 (fr) Traitement de la demence fronto-temporale.
US20190161535A1 (en) Compositions and methods for treating spinal muscular atrophy
CN109311992B (zh) 用于治疗t细胞介导疾病的新型抗cd6抗体
SA111320266B1 (ar) أجسام مضادة مع ارتباط مولد مضاد يعتمد على الأس الهيدروجيني
EP3454902A1 (fr) Anticorps anti-facteur du complément c4/c4b et utilisations de ceux-ci
US11702467B2 (en) High affinity antibodies targeting tau phosphorylated at serine 413
US20240083989A1 (en) Compositions and methods for treating brain injury
US20240109957A1 (en) Compositions and methods for treating blood disorders
US20240034775A1 (en) Compositions and methods for treating epilepsy
CA3195798A1 (fr) Compositions et procedes pour traitement de troubles sanguins

Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20230119

FZDE Discontinued

Effective date: 20230119