CA3030255C - Methods and systems for determining autism spectrum disorder risk - Google Patents

Methods and systems for determining autism spectrum disorder risk Download PDF

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Publication number
CA3030255C
CA3030255C CA3030255A CA3030255A CA3030255C CA 3030255 C CA3030255 C CA 3030255C CA 3030255 A CA3030255 A CA 3030255A CA 3030255 A CA3030255 A CA 3030255A CA 3030255 C CA3030255 C CA 3030255C
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Prior art keywords
asd
metabolites
metabolite
tail
sulfate
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CA3030255A
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English (en)
French (fr)
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CA3030255A1 (en
Inventor
Ute GEIGENMULLER
Doris Damian
Maciej PACULA
Mark A. DEPRISTO
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SynapDx Corp
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SynapDx Corp
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Priority claimed from US14/493,141 external-priority patent/US20150294081A1/en
Application filed by SynapDx Corp filed Critical SynapDx Corp
Priority to CA3157221A priority Critical patent/CA3157221A1/en
Publication of CA3030255A1 publication Critical patent/CA3030255A1/en
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Publication of CA3030255C publication Critical patent/CA3030255C/en
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/492—Determining multiple analytes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/70—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving creatine or creatinine
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Ecology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
CA3030255A 2014-04-11 2015-04-10 Methods and systems for determining autism spectrum disorder risk Active CA3030255C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3157221A CA3157221A1 (en) 2014-04-11 2015-04-10 Methods and systems for determining autism spectrum disorder risk

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201461978773P 2014-04-11 2014-04-11
US61/978,773 2014-04-11
US201462002169P 2014-05-22 2014-05-22
US62/002,169 2014-05-22
US14/493,141 2014-09-22
US14/493,141 US20150294081A1 (en) 2014-04-11 2014-09-22 Methods and systems for determining autism spectrum disorder risk
US14/633,558 US9176113B1 (en) 2014-04-11 2015-02-27 Methods and systems for determining autism spectrum disorder risk
US14/633,558 2015-02-27
CA2945528A CA2945528C (en) 2014-04-11 2015-04-10 Methods and systems for determining autism spectrum disorder risk

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2945528A Division CA2945528C (en) 2014-04-11 2015-04-10 Methods and systems for determining autism spectrum disorder risk

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3157221A Division CA3157221A1 (en) 2014-04-11 2015-04-10 Methods and systems for determining autism spectrum disorder risk

Publications (2)

Publication Number Publication Date
CA3030255A1 CA3030255A1 (en) 2015-10-15
CA3030255C true CA3030255C (en) 2022-07-05

Family

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CA3157221A Pending CA3157221A1 (en) 2014-04-11 2015-04-10 Methods and systems for determining autism spectrum disorder risk
CA3030255A Active CA3030255C (en) 2014-04-11 2015-04-10 Methods and systems for determining autism spectrum disorder risk
CA2945528A Active CA2945528C (en) 2014-04-11 2015-04-10 Methods and systems for determining autism spectrum disorder risk

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CA3157221A Pending CA3157221A1 (en) 2014-04-11 2015-04-10 Methods and systems for determining autism spectrum disorder risk

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CA2945528A Active CA2945528C (en) 2014-04-11 2015-04-10 Methods and systems for determining autism spectrum disorder risk

Country Status (6)

Country Link
US (3) US9176113B1 (cg-RX-API-DMAC7.html)
EP (2) EP3954991A3 (cg-RX-API-DMAC7.html)
JP (5) JP6550124B2 (cg-RX-API-DMAC7.html)
CN (2) CN106714556B (cg-RX-API-DMAC7.html)
CA (3) CA3157221A1 (cg-RX-API-DMAC7.html)
WO (1) WO2015157601A1 (cg-RX-API-DMAC7.html)

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US20150294081A1 (en) 2014-04-11 2015-10-15 Synapdx Corporation Methods and systems for determining autism spectrum disorder risk
HUE056203T2 (hu) * 2015-01-09 2022-01-28 Global Genomics Group Llc Vér alapú biomarkerek atheroszklerotikus koszorúsér betegség diagnosztizálására
US10525020B2 (en) 2015-02-11 2020-01-07 Laboratory Corporation Of America Holdings Metabolic markers of attention deficit hyperactivity disorder
CN114470009A (zh) 2015-05-22 2022-05-13 亚利桑那大学董事会 用于治疗自闭症谱系障碍及相关症状的方法
WO2017197252A1 (en) * 2016-05-13 2017-11-16 Stemina Biomarker Discovery, Inc. Autism subsets
WO2018089794A1 (en) * 2016-11-11 2018-05-17 Arizona Board Of Regents On Behalf Of Arizona State University Methods and compositions for changing metabolite levels in a subject
US11865145B2 (en) 2017-08-07 2024-01-09 Finch Therapeutics Holdings Llc Compositions and methods for maintaining and restoring a healthy gut barrier
EP3756187A4 (en) * 2018-02-19 2021-12-08 The Regents of the University of Colorado, a body corporate OXOPIPERIDE INQUANTIZATION USING MASS SPECTROMETRY
CN112689755A (zh) * 2018-09-11 2021-04-20 梅塔博隆股份有限公司 用于检测和定量微生物区系相关代谢物的质谱测定法
CN110487922B (zh) * 2018-12-17 2022-09-27 广西中烟工业有限责任公司 一种烟叶中苏糖酸和苏糖酸酯的gc-ms分析方法
EP3948277A4 (en) * 2019-04-05 2023-05-24 Arizona Board of Regents on behalf of Arizona State University METABOLITES AS DIAGNOSTICS OF AUTISTIC SPECTRUM DISEASE IN CHILDREN WITH GASTROINTESTINAL SYMPTOMS
US20220208386A1 (en) * 2019-04-05 2022-06-30 Arizona Board Of Regents On Behalf Of Arizona State University Diagnostic for maternal risk of having a child with autism spectrum disorder
WO2020242744A1 (en) * 2019-05-31 2020-12-03 Metabolon, Inc. Mass spectrometry assay methods for detection of metabolites
JP2022541795A (ja) 2019-07-19 2022-09-27 フィンチ セラピューティクス ホールディングス エルエルシー 胃腸障害の治療のための方法および産物
CN112180005B (zh) * 2020-09-01 2022-10-04 上海市疾病预防控制中心 一种预测鉴定生物样本中酰基肉碱的方法及其应用
KR20230074216A (ko) * 2020-09-21 2023-05-26 몰레큘러 유 코포레이션 자폐 스펙트럼 장애의 진단 및 치료 방법
CN113539478B (zh) * 2021-06-24 2023-04-07 山西医科大学 基于代谢组学的深静脉血栓形成预测模型的建立方法
CN115938490B (zh) * 2023-03-07 2023-06-06 之江实验室 一种基于图表示学习算法的代谢物鉴定方法、系统和设备

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Also Published As

Publication number Publication date
JP2023178345A (ja) 2023-12-14
JP2019200210A (ja) 2019-11-21
JP6550124B2 (ja) 2019-07-24
US20150293072A1 (en) 2015-10-15
US20240019417A1 (en) 2024-01-18
CA2945528A1 (en) 2015-10-15
EP3954991A2 (en) 2022-02-16
CA3157221A1 (en) 2015-10-15
JP2021103177A (ja) 2021-07-15
US20160091481A1 (en) 2016-03-31
WO2015157601A1 (en) 2015-10-15
CN113009122B (zh) 2025-01-17
EP3151665A1 (en) 2017-04-12
EP3151665A4 (en) 2018-04-25
CN113009122A (zh) 2021-06-22
EP3954991A3 (en) 2022-05-18
EP3151665B1 (en) 2021-03-10
JP2017510821A (ja) 2017-04-13
CN106714556A (zh) 2017-05-24
US9176113B1 (en) 2015-11-03
JP2025172836A (ja) 2025-11-26
CA3030255A1 (en) 2015-10-15
CN106714556B (zh) 2021-01-26
CA2945528C (en) 2019-03-12

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