CA3027154C - Microfluidic device - Google Patents
Microfluidic device Download PDFInfo
- Publication number
- CA3027154C CA3027154C CA3027154A CA3027154A CA3027154C CA 3027154 C CA3027154 C CA 3027154C CA 3027154 A CA3027154 A CA 3027154A CA 3027154 A CA3027154 A CA 3027154A CA 3027154 C CA3027154 C CA 3027154C
- Authority
- CA
- Canada
- Prior art keywords
- fluid
- layers
- layer
- particles
- channel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000002245 particle Substances 0.000 claims abstract description 194
- 239000012530 fluid Substances 0.000 claims abstract description 183
- 238000000034 method Methods 0.000 claims abstract description 36
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
- 238000004891 communication Methods 0.000 claims description 15
- 239000007788 liquid Substances 0.000 claims description 13
- 238000000576 coating method Methods 0.000 claims description 11
- 239000011248 coating agent Substances 0.000 claims description 8
- 239000010410 layer Substances 0.000 description 185
- 239000011324 bead Substances 0.000 description 32
- 238000012360 testing method Methods 0.000 description 26
- 239000000523 sample Substances 0.000 description 19
- 238000009826 distribution Methods 0.000 description 18
- 230000008569 process Effects 0.000 description 15
- 238000010904 focused beam reflectance measurement Methods 0.000 description 14
- 238000001914 filtration Methods 0.000 description 9
- 210000003250 oocyst Anatomy 0.000 description 9
- 239000000853 adhesive Substances 0.000 description 8
- 230000001070 adhesive effect Effects 0.000 description 8
- 239000000463 material Substances 0.000 description 8
- 238000007789 sealing Methods 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 238000001514 detection method Methods 0.000 description 6
- 239000011325 microbead Substances 0.000 description 6
- 238000012545 processing Methods 0.000 description 6
- 238000000926 separation method Methods 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 239000004014 plasticizer Substances 0.000 description 5
- 241000894007 species Species 0.000 description 5
- 238000012546 transfer Methods 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000001124 body fluid Anatomy 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 239000012141 concentrate Substances 0.000 description 4
- 239000000356 contaminant Substances 0.000 description 4
- 238000013461 design Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 239000002609 medium Substances 0.000 description 4
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 4
- 239000004926 polymethyl methacrylate Substances 0.000 description 4
- 238000005086 pumping Methods 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- 241000223935 Cryptosporidium Species 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000012634 fragment Substances 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 244000000028 waterborne pathogen Species 0.000 description 3
- BEIGFKLRGRRJJA-JLHYYAGUSA-O 2-(2f-benzothiazolyl)-5-styryl-3-(4f-phthalhydrazidyl)tetrazolium chloride Chemical compound C=1C=C2C(=O)NNC(=O)C2=CC=1[N+](N(N=1)C=2SC3=CC=CC=C3N=2)=NC=1\C=C\C1=CC=CC=C1 BEIGFKLRGRRJJA-JLHYYAGUSA-O 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 241000223936 Cryptosporidium parvum Species 0.000 description 2
- 241000224466 Giardia Species 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000003491 array Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- FFBHFFJDDLITSX-UHFFFAOYSA-N benzyl N-[2-hydroxy-4-(3-oxomorpholin-4-yl)phenyl]carbamate Chemical compound OC1=C(NC(=O)OCC2=CC=CC=C2)C=CC(=C1)N1CCOCC1=O FFBHFFJDDLITSX-UHFFFAOYSA-N 0.000 description 2
- 210000000601 blood cell Anatomy 0.000 description 2
- 229940098773 bovine serum albumin Drugs 0.000 description 2
- 230000004087 circulation Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 239000012149 elution buffer Substances 0.000 description 2
- 238000003698 laser cutting Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- -1 poly(methyl methacrylate) Polymers 0.000 description 2
- 239000004417 polycarbonate Substances 0.000 description 2
- 229920000515 polycarbonate Polymers 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 238000004088 simulation Methods 0.000 description 2
- 210000000130 stem cell Anatomy 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 239000008399 tap water Substances 0.000 description 2
- 235000020679 tap water Nutrition 0.000 description 2
- 238000010146 3D printing Methods 0.000 description 1
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 1
- 239000012790 adhesive layer Substances 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- WYTGDNHDOZPMIW-RCBQFDQVSA-N alstonine Natural products C1=CC2=C3C=CC=CC3=NC2=C2N1C[C@H]1[C@H](C)OC=C(C(=O)OC)[C@H]1C2 WYTGDNHDOZPMIW-RCBQFDQVSA-N 0.000 description 1
- 210000004381 amniotic fluid Anatomy 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 230000002902 bimodal effect Effects 0.000 description 1
- 239000002551 biofuel Substances 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 238000011088 calibration curve Methods 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 210000004252 chorionic villi Anatomy 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000012468 concentrated sample Substances 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000004720 dielectrophoresis Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 239000013013 elastic material Substances 0.000 description 1
- 238000000835 electrochemical detection Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000004700 fetal blood Anatomy 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000003116 impacting effect Effects 0.000 description 1
- 238000002032 lab-on-a-chip Methods 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005459 micromachining Methods 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 229920005644 polyethylene terephthalate glycol copolymer Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 238000007781 pre-processing Methods 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 238000012958 reprocessing Methods 0.000 description 1
- 238000007788 roughening Methods 0.000 description 1
- 238000010079 rubber tapping Methods 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 229910000077 silane Inorganic materials 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502776—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0636—Focussing flows, e.g. to laminate flows
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0652—Sorting or classification of particles or molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/088—Channel loops
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
- B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Sampling And Sample Adjustment (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1510189.2A GB201510189D0 (en) | 2015-06-11 | 2015-06-11 | Microfluidic device |
| GB1510189.2 | 2015-06-11 | ||
| PCT/GB2016/051713 WO2016198880A1 (en) | 2015-06-11 | 2016-06-10 | Microfluidic device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA3027154A1 CA3027154A1 (en) | 2016-12-15 |
| CA3027154C true CA3027154C (en) | 2023-03-21 |
Family
ID=53784509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3027154A Active CA3027154C (en) | 2015-06-11 | 2016-06-10 | Microfluidic device |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10688490B2 (enExample) |
| EP (1) | EP3307436B1 (enExample) |
| JP (1) | JP6746619B2 (enExample) |
| AU (1) | AU2016276131B2 (enExample) |
| BR (1) | BR112017026602A2 (enExample) |
| CA (1) | CA3027154C (enExample) |
| DK (1) | DK3307436T3 (enExample) |
| ES (1) | ES2784933T3 (enExample) |
| GB (1) | GB201510189D0 (enExample) |
| PL (1) | PL3307436T3 (enExample) |
| PT (1) | PT3307436T (enExample) |
| WO (1) | WO2016198880A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017131580A1 (en) * | 2016-01-28 | 2017-08-03 | Clearbridge Biomedics Pte Ltd | Multi-stage target cell enrichment using a microfluidic device |
| BR122020022711B1 (pt) | 2016-11-07 | 2021-09-14 | The Climate Corporation | Implemento agrícola e método |
| CA3182488C (en) | 2018-07-10 | 2025-06-10 | Prec Planting Llc | AGRICULTURAL SAMPLING SYSTEM AND RELATED METHODS |
| GB201820944D0 (en) * | 2018-12-21 | 2019-02-06 | Ufraction8 Ltd | Microfluid device |
| KR102370142B1 (ko) * | 2020-03-23 | 2022-03-04 | 프레스티지바이오로직스 주식회사 | 항체 의약품 제조를 위한 배양 및 정제 공정의 하이브리드 시스템 |
| US20230285969A1 (en) * | 2022-03-10 | 2023-09-14 | City University Of Hong Kong | Microfluidic chamber, microfluidic device containing a water purification system, and a water purification method |
| CN114558631B (zh) * | 2022-03-17 | 2023-04-07 | 中南大学 | 一种微流控设备、微流体样品输入系统及控制方法 |
| CN115069134B (zh) * | 2022-07-07 | 2023-09-05 | 山东省科学院能源研究所 | 一种基于迪恩涡流的微流体高效混合器 |
| WO2025233956A1 (en) * | 2024-05-07 | 2025-11-13 | Indian Institute Of Technology Hyderabad | An integrated lab on chip device for the isolation, lysis and detection of pathogen from body fluids |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2923436B2 (ja) * | 1993-10-13 | 1999-07-26 | 株式会社ファインクレイ | 懸濁質粒子の分級方法 |
| JP2004330008A (ja) * | 2003-05-01 | 2004-11-25 | Rikogaku Shinkokai | マイクロチャンネル装置 |
| US7160025B2 (en) * | 2003-06-11 | 2007-01-09 | Agency For Science, Technology And Research | Micromixer apparatus and methods of using same |
| EP1915467A2 (en) * | 2005-08-19 | 2008-04-30 | The Regents of the University of California | Microfluidic methods for diagnostics and cellular analysis |
| JP2007148981A (ja) * | 2005-11-30 | 2007-06-14 | Univ Waseda | 微粒子分別マイクロシステムおよび微粒子分別方法 |
| US10052571B2 (en) * | 2007-11-07 | 2018-08-21 | Palo Alto Research Center Incorporated | Fluidic device and method for separation of neutrally buoyant particles |
| US9486812B2 (en) | 2006-11-30 | 2016-11-08 | Palo Alto Research Center Incorporated | Fluidic structures for membraneless particle separation |
| BRPI1008965B1 (pt) * | 2009-03-13 | 2018-12-18 | Harvard College | método para aumento de escala de dispositivos microfluídicos e sistema para a formação de gotículas em canais microfluídicos em paralelo |
| JP5459471B2 (ja) * | 2009-07-16 | 2014-04-02 | 富士ゼロックス株式会社 | 送液方法及び分級方法 |
| US8208138B2 (en) | 2009-09-24 | 2012-06-26 | University Of Cincinnati | Spiral microchannel particle separators, straight microchannel particle separators, and continuous particle separator and detector systems |
| SG10201501485QA (en) | 2010-03-04 | 2015-04-29 | Univ Singapore | Microfluidics sorter for cell detection and isolation |
| US9149806B2 (en) | 2012-01-10 | 2015-10-06 | Biopico Systems Inc | Microfluidic devices and methods for cell sorting, cell culture and cells based diagnostics and therapeutics |
| EP3628401B1 (en) * | 2012-09-21 | 2021-06-23 | Massachusetts Institute Of Technology | Micro-fluidic device and uses thereof |
| JP6501709B2 (ja) * | 2012-09-28 | 2019-04-17 | キヤノン ユー.エス. ライフ サイエンシズ, インコーポレイテッドCanon U.S. Life Sciences, Inc. | スパイラル慣性濾過を使用する粒子分離及び濃縮 |
| WO2014113598A2 (en) | 2013-01-16 | 2014-07-24 | The Regents Of The University Of California | Microfluidic devices to extract, concentrate and isolate molecules |
| US10371622B2 (en) * | 2013-03-14 | 2019-08-06 | Inguran, Llc | Device for high throughput sperm sorting |
| US10105700B2 (en) * | 2013-07-17 | 2018-10-23 | The Johns Hopkins University | Microfluidic chip for analysis of cell motility and methods for using same |
| US11396012B2 (en) * | 2013-10-07 | 2022-07-26 | Yeda Research And Development Co. Ltd. | Microfluidic device for analyzing gene expression |
| US10144009B2 (en) | 2013-10-16 | 2018-12-04 | Clearbridge Biomedics Pte Ltd | Microfluidics sorter for cell detection and isolation |
-
2015
- 2015-06-11 GB GBGB1510189.2A patent/GB201510189D0/en not_active Ceased
-
2016
- 2016-06-10 WO PCT/GB2016/051713 patent/WO2016198880A1/en not_active Ceased
- 2016-06-10 AU AU2016276131A patent/AU2016276131B2/en active Active
- 2016-06-10 CA CA3027154A patent/CA3027154C/en active Active
- 2016-06-10 EP EP16729341.4A patent/EP3307436B1/en active Active
- 2016-06-10 US US15/580,359 patent/US10688490B2/en active Active
- 2016-06-10 DK DK16729341.4T patent/DK3307436T3/da active
- 2016-06-10 ES ES16729341T patent/ES2784933T3/es active Active
- 2016-06-10 JP JP2017563516A patent/JP6746619B2/ja active Active
- 2016-06-10 PT PT167293414T patent/PT3307436T/pt unknown
- 2016-06-10 BR BR112017026602-4A patent/BR112017026602A2/pt not_active Application Discontinuation
- 2016-06-10 PL PL16729341T patent/PL3307436T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2016276131A1 (en) | 2017-12-14 |
| ES2784933T3 (es) | 2020-10-02 |
| US20180185845A1 (en) | 2018-07-05 |
| EP3307436B1 (en) | 2020-03-25 |
| CA3027154A1 (en) | 2016-12-15 |
| BR112017026602A2 (pt) | 2018-08-14 |
| WO2016198880A1 (en) | 2016-12-15 |
| AU2016276131B2 (en) | 2021-09-30 |
| EP3307436A1 (en) | 2018-04-18 |
| GB201510189D0 (en) | 2015-07-29 |
| PL3307436T3 (pl) | 2020-08-24 |
| JP6746619B2 (ja) | 2020-08-26 |
| JP2018528391A (ja) | 2018-09-27 |
| PT3307436T (pt) | 2020-04-22 |
| DK3307436T3 (da) | 2020-04-27 |
| US10688490B2 (en) | 2020-06-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA3027154C (en) | Microfluidic device | |
| JP7042289B2 (ja) | ミクロ流体装置による粒子の複合式分類および濃縮 | |
| US10596522B2 (en) | Hemolysis-free blood plasma separation | |
| JP4982768B2 (ja) | 粒子処理用マイクロ流路システムおよび粒子処理方法 | |
| EP3455337A1 (en) | Systems and methods for enriching target cells in a sample | |
| US20230347345A1 (en) | Spiral inertial microfluidic devices and methods to remove contaminants | |
| US12325021B2 (en) | Microfluidic device | |
| US20160258928A1 (en) | Microfluidic device for separating liquid from the same liquid containing deformable particles without external sources of energy | |
| WO2023211901A1 (en) | Spiral inertial microfluidic devices and methods to remove contaminants | |
| HK1243765B (en) | Combined sorting and concentrating particles in a microfluidic device | |
| HK1242781A1 (en) | Combined sorting and concentrating particles in a microfluidic device | |
| HK1243669B (en) | Sorting particles in a microfluidic device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20210224 |
|
| EEER | Examination request |
Effective date: 20210224 |
|
| EEER | Examination request |
Effective date: 20210224 |
|
| EEER | Examination request |
Effective date: 20210224 |
|
| EEER | Examination request |
Effective date: 20210224 |
|
| EEER | Examination request |
Effective date: 20210224 |