CA3027154C - Microfluidic device - Google Patents

Microfluidic device Download PDF

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Publication number
CA3027154C
CA3027154C CA3027154A CA3027154A CA3027154C CA 3027154 C CA3027154 C CA 3027154C CA 3027154 A CA3027154 A CA 3027154A CA 3027154 A CA3027154 A CA 3027154A CA 3027154 C CA3027154 C CA 3027154C
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CA
Canada
Prior art keywords
fluid
layers
layer
particles
channel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3027154A
Other languages
English (en)
French (fr)
Other versions
CA3027154A1 (en
Inventor
Helen Louise BRIDLE
Brian Maxdell MILLER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ufraction8 Ltd
Original Assignee
Heriot-Watt University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heriot-Watt University filed Critical Heriot-Watt University
Publication of CA3027154A1 publication Critical patent/CA3027154A1/en
Application granted granted Critical
Publication of CA3027154C publication Critical patent/CA3027154C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502776—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0636—Focussing flows, e.g. to laminate flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/088—Channel loops
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
CA3027154A 2015-06-11 2016-06-10 Microfluidic device Active CA3027154C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1510189.2 2015-06-11
GBGB1510189.2A GB201510189D0 (en) 2015-06-11 2015-06-11 Microfluidic device
PCT/GB2016/051713 WO2016198880A1 (en) 2015-06-11 2016-06-10 Microfluidic device

Publications (2)

Publication Number Publication Date
CA3027154A1 CA3027154A1 (en) 2016-12-15
CA3027154C true CA3027154C (en) 2023-03-21

Family

ID=53784509

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3027154A Active CA3027154C (en) 2015-06-11 2016-06-10 Microfluidic device

Country Status (12)

Country Link
US (1) US10688490B2 (enExample)
EP (1) EP3307436B1 (enExample)
JP (1) JP6746619B2 (enExample)
AU (1) AU2016276131B2 (enExample)
BR (1) BR112017026602A2 (enExample)
CA (1) CA3027154C (enExample)
DK (1) DK3307436T3 (enExample)
ES (1) ES2784933T3 (enExample)
GB (1) GB201510189D0 (enExample)
PL (1) PL3307436T3 (enExample)
PT (1) PT3307436T (enExample)
WO (1) WO2016198880A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6845246B2 (ja) * 2016-01-28 2021-03-17 バイオリディックス リミテッドＢｉｏｌｉｄｉｃｓ Ｌｉｍｉｔｅｄ マイクロ流体デバイスを用いたマルチステージ標的細胞富化
US10701856B2 (en) 2016-11-07 2020-07-07 The Climate Corporation Agricultural implements for soil and vegetation analysis
EP3821223B1 (en) 2018-07-10 2024-10-09 Precision Planting LLC Agricultural sampling system and related methods
GB201820944D0 (en) 2018-12-21 2019-02-06 Ufraction8 Ltd Microfluid device
GB201913529D0 (en) 2019-09-19 2019-11-06 Tanriverdi Ugur Method And Apparatus
KR102370142B1 (ko) * 2020-03-23 2022-03-04 프레스티지바이오로직스 주식회사 항체 의약품 제조를 위한 배양 및 정제 공정의 하이브리드 시스템
US20230285969A1 (en) * 2022-03-10 2023-09-14 City University Of Hong Kong Microfluidic chamber, microfluidic device containing a water purification system, and a water purification method
CN114558631B (zh) * 2022-03-17 2023-04-07 中南大学 一种微流控设备、微流体样品输入系统及控制方法
CN115069134B (zh) * 2022-07-07 2023-09-05 山东省科学院能源研究所 一种基于迪恩涡流的微流体高效混合器
WO2025233956A1 (en) * 2024-05-07 2025-11-13 Indian Institute Of Technology Hyderabad An integrated lab on chip device for the isolation, lysis and detection of pathogen from body fluids

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2923436B2 (ja) * 1993-10-13 1999-07-26 株式会社ファインクレイ 懸濁質粒子の分級方法
JP2004330008A (ja) * 2003-05-01 2004-11-25 Rikogaku Shinkokai マイクロチャンネル装置
US7160025B2 (en) * 2003-06-11 2007-01-09 Agency For Science, Technology And Research Micromixer apparatus and methods of using same
EP1915467A2 (en) * 2005-08-19 2008-04-30 The Regents of the University of California Microfluidic methods for diagnostics and cellular analysis
JP2007148981A (ja) * 2005-11-30 2007-06-14 Univ Waseda 微粒子分別マイクロシステムおよび微粒子分別方法
US10052571B2 (en) * 2007-11-07 2018-08-21 Palo Alto Research Center Incorporated Fluidic device and method for separation of neutrally buoyant particles
US9486812B2 (en) * 2006-11-30 2016-11-08 Palo Alto Research Center Incorporated Fluidic structures for membraneless particle separation
KR101793744B1 (ko) * 2009-03-13 2017-11-03 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 유동 포커싱 미세유동 장치의 규모 확장
JP5459471B2 (ja) * 2009-07-16 2014-04-02 富士ゼロックス株式会社 送液方法及び分級方法
US8208138B2 (en) 2009-09-24 2012-06-26 University Of Cincinnati Spiral microchannel particle separators, straight microchannel particle separators, and continuous particle separator and detector systems
US9458489B2 (en) 2010-03-04 2016-10-04 Massachusetts Institute Of Technology Microfluidics sorter for cell detection and isolation
US9149806B2 (en) 2012-01-10 2015-10-06 Biopico Systems Inc Microfluidic devices and methods for cell sorting, cell culture and cells based diagnostics and therapeutics
AU2013318647B2 (en) * 2012-09-21 2017-10-26 Massachusetts Institute Of Technology Micro-fluidic device and uses thereof
US9804068B2 (en) * 2012-09-28 2017-10-31 University Of Maryland Particle separation and concentration using spiral inertial filtration
WO2014113598A2 (en) 2013-01-16 2014-07-24 The Regents Of The University Of California Microfluidic devices to extract, concentrate and isolate molecules
US10371622B2 (en) * 2013-03-14 2019-08-06 Inguran, Llc Device for high throughput sperm sorting
WO2015009688A1 (en) * 2013-07-17 2015-01-22 The Johns Hopkins University Microfluidic chip for analysis of cell motility and methods for using same
WO2015052717A1 (en) * 2013-10-07 2015-04-16 Yeda Research And Development Co. Ltd. Microfluidic device for analyzing gene expression
US10144009B2 (en) 2013-10-16 2018-12-04 Clearbridge Biomedics Pte Ltd Microfluidics sorter for cell detection and isolation

Also Published As

Publication number Publication date
JP6746619B2 (ja) 2020-08-26
BR112017026602A2 (pt) 2018-08-14
ES2784933T3 (es) 2020-10-02
JP2018528391A (ja) 2018-09-27
CA3027154A1 (en) 2016-12-15
GB201510189D0 (en) 2015-07-29
US10688490B2 (en) 2020-06-23
AU2016276131A1 (en) 2017-12-14
EP3307436B1 (en) 2020-03-25
EP3307436A1 (en) 2018-04-18
US20180185845A1 (en) 2018-07-05
DK3307436T3 (da) 2020-04-27
AU2016276131B2 (en) 2021-09-30
WO2016198880A1 (en) 2016-12-15
PL3307436T3 (pl) 2020-08-24
PT3307436T (pt) 2020-04-22

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