AU2016276131B2 - Microfluidic device - Google Patents

Microfluidic device Download PDF

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Publication number
AU2016276131B2
AU2016276131B2 AU2016276131A AU2016276131A AU2016276131B2 AU 2016276131 B2 AU2016276131 B2 AU 2016276131B2 AU 2016276131 A AU2016276131 A AU 2016276131A AU 2016276131 A AU2016276131 A AU 2016276131A AU 2016276131 B2 AU2016276131 B2 AU 2016276131B2
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AU
Australia
Prior art keywords
fluid
layers
layer
particles
channel
Prior art date
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Active
Application number
AU2016276131A
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English (en)
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AU2016276131A1 (en
Inventor
Helen Louise BRIDLE
Brian Maxdell MILLER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ufraction8 Ltd
Original Assignee
Ufraction8 Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Publication of AU2016276131A1 publication Critical patent/AU2016276131A1/en
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Assigned to uFraction8 Limited reassignment uFraction8 Limited Request for Assignment Assignors: HERIOT-WATT UNIVERSITY
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502776—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0636—Focussing flows, e.g. to laminate flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/088—Channel loops
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
AU2016276131A 2015-06-11 2016-06-10 Microfluidic device Active AU2016276131B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1510189.2A GB201510189D0 (en) 2015-06-11 2015-06-11 Microfluidic device
GB1510189.2 2015-06-11
PCT/GB2016/051713 WO2016198880A1 (en) 2015-06-11 2016-06-10 Microfluidic device

Publications (2)

Publication Number Publication Date
AU2016276131A1 AU2016276131A1 (en) 2017-12-14
AU2016276131B2 true AU2016276131B2 (en) 2021-09-30

Family

ID=53784509

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2016276131A Active AU2016276131B2 (en) 2015-06-11 2016-06-10 Microfluidic device

Country Status (12)

Country Link
US (1) US10688490B2 (enExample)
EP (1) EP3307436B1 (enExample)
JP (1) JP6746619B2 (enExample)
AU (1) AU2016276131B2 (enExample)
BR (1) BR112017026602A2 (enExample)
CA (1) CA3027154C (enExample)
DK (1) DK3307436T3 (enExample)
ES (1) ES2784933T3 (enExample)
GB (1) GB201510189D0 (enExample)
PL (1) PL3307436T3 (enExample)
PT (1) PT3307436T (enExample)
WO (1) WO2016198880A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017131580A1 (en) * 2016-01-28 2017-08-03 Clearbridge Biomedics Pte Ltd Multi-stage target cell enrichment using a microfluidic device
BR122020022711B1 (pt) 2016-11-07 2021-09-14 The Climate Corporation Implemento agrícola e método
CA3182488C (en) 2018-07-10 2025-06-10 Prec Planting Llc AGRICULTURAL SAMPLING SYSTEM AND RELATED METHODS
GB201820944D0 (en) * 2018-12-21 2019-02-06 Ufraction8 Ltd Microfluid device
KR102370142B1 (ko) * 2020-03-23 2022-03-04 프레스티지바이오로직스 주식회사 항체 의약품 제조를 위한 배양 및 정제 공정의 하이브리드 시스템
US20230285969A1 (en) * 2022-03-10 2023-09-14 City University Of Hong Kong Microfluidic chamber, microfluidic device containing a water purification system, and a water purification method
CN114558631B (zh) * 2022-03-17 2023-04-07 中南大学 一种微流控设备、微流体样品输入系统及控制方法
CN115069134B (zh) * 2022-07-07 2023-09-05 山东省科学院能源研究所 一种基于迪恩涡流的微流体高效混合器
WO2025233956A1 (en) * 2024-05-07 2025-11-13 Indian Institute Of Technology Hyderabad An integrated lab on chip device for the isolation, lysis and detection of pathogen from body fluids

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2060312A2 (en) * 2007-11-07 2009-05-20 Palo Alto Research Center Incorporated Fluidic device and method for separation of neutrally buoyant particles
EP2127752A2 (en) * 2008-05-13 2009-12-02 Palo Alto Research Center Incorporated Fluidic structures for membraneless particle separation

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JP2923436B2 (ja) * 1993-10-13 1999-07-26 株式会社ファインクレイ 懸濁質粒子の分級方法
JP2004330008A (ja) * 2003-05-01 2004-11-25 Rikogaku Shinkokai マイクロチャンネル装置
US7160025B2 (en) * 2003-06-11 2007-01-09 Agency For Science, Technology And Research Micromixer apparatus and methods of using same
EP1915467A2 (en) * 2005-08-19 2008-04-30 The Regents of the University of California Microfluidic methods for diagnostics and cellular analysis
JP2007148981A (ja) * 2005-11-30 2007-06-14 Univ Waseda 微粒子分別マイクロシステムおよび微粒子分別方法
BRPI1008965B1 (pt) * 2009-03-13 2018-12-18 Harvard College método para aumento de escala de dispositivos microfluídicos e sistema para a formação de gotículas em canais microfluídicos em paralelo
JP5459471B2 (ja) * 2009-07-16 2014-04-02 富士ゼロックス株式会社 送液方法及び分級方法
US8208138B2 (en) 2009-09-24 2012-06-26 University Of Cincinnati Spiral microchannel particle separators, straight microchannel particle separators, and continuous particle separator and detector systems
SG10201501485QA (en) 2010-03-04 2015-04-29 Univ Singapore Microfluidics sorter for cell detection and isolation
US9149806B2 (en) 2012-01-10 2015-10-06 Biopico Systems Inc Microfluidic devices and methods for cell sorting, cell culture and cells based diagnostics and therapeutics
EP3628401B1 (en) * 2012-09-21 2021-06-23 Massachusetts Institute Of Technology Micro-fluidic device and uses thereof
JP6501709B2 (ja) * 2012-09-28 2019-04-17 キヤノン ユー．エス． ライフ サイエンシズ， インコーポレイテッドＣａｎｏｎ Ｕ．Ｓ． Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ， Ｉｎｃ． スパイラル慣性濾過を使用する粒子分離及び濃縮
WO2014113598A2 (en) 2013-01-16 2014-07-24 The Regents Of The University Of California Microfluidic devices to extract, concentrate and isolate molecules
US10371622B2 (en) * 2013-03-14 2019-08-06 Inguran, Llc Device for high throughput sperm sorting
US10105700B2 (en) * 2013-07-17 2018-10-23 The Johns Hopkins University Microfluidic chip for analysis of cell motility and methods for using same
US11396012B2 (en) * 2013-10-07 2022-07-26 Yeda Research And Development Co. Ltd. Microfluidic device for analyzing gene expression
US10144009B2 (en) 2013-10-16 2018-12-04 Clearbridge Biomedics Pte Ltd Microfluidics sorter for cell detection and isolation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2060312A2 (en) * 2007-11-07 2009-05-20 Palo Alto Research Center Incorporated Fluidic device and method for separation of neutrally buoyant particles
EP2127752A2 (en) * 2008-05-13 2009-12-02 Palo Alto Research Center Incorporated Fluidic structures for membraneless particle separation

Also Published As

Publication number Publication date
AU2016276131A1 (en) 2017-12-14
ES2784933T3 (es) 2020-10-02
US20180185845A1 (en) 2018-07-05
EP3307436B1 (en) 2020-03-25
CA3027154A1 (en) 2016-12-15
BR112017026602A2 (pt) 2018-08-14
CA3027154C (en) 2023-03-21
WO2016198880A1 (en) 2016-12-15
EP3307436A1 (en) 2018-04-18
GB201510189D0 (en) 2015-07-29
PL3307436T3 (pl) 2020-08-24
JP6746619B2 (ja) 2020-08-26
JP2018528391A (ja) 2018-09-27
PT3307436T (pt) 2020-04-22
DK3307436T3 (da) 2020-04-27
US10688490B2 (en) 2020-06-23

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FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: UFRACTION8 LIMITED

Free format text: FORMER OWNER(S): HERIOT-WATT UNIVERSITY