CA3027127A1 - Systems and methods for automated annotation and screening of biological sequences - Google Patents
Systems and methods for automated annotation and screening of biological sequences Download PDFInfo
- Publication number
- CA3027127A1 CA3027127A1 CA3027127A CA3027127A CA3027127A1 CA 3027127 A1 CA3027127 A1 CA 3027127A1 CA 3027127 A CA3027127 A CA 3027127A CA 3027127 A CA3027127 A CA 3027127A CA 3027127 A1 CA3027127 A1 CA 3027127A1
- Authority
- CA
- Canada
- Prior art keywords
- biological
- sequences
- sequence
- harmful
- instructions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims description 127
- 238000012216 screening Methods 0.000 title abstract description 53
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 61
- 108091033319 polynucleotide Proteins 0.000 claims abstract description 20
- 239000002157 polynucleotide Substances 0.000 claims abstract description 20
- 102000040430 polynucleotide Human genes 0.000 claims abstract description 20
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 11
- 238000003786 synthesis reaction Methods 0.000 claims abstract description 11
- 150000007523 nucleic acids Chemical class 0.000 claims description 58
- 238000013461 design Methods 0.000 claims description 41
- 102000039446 nucleic acids Human genes 0.000 claims description 27
- 108020004707 nucleic acids Proteins 0.000 claims description 27
- 108091005461 Nucleic proteins Proteins 0.000 claims description 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 4
- 238000012163 sequencing technique Methods 0.000 claims description 3
- 108090000623 proteins and genes Proteins 0.000 abstract description 59
- 230000014509 gene expression Effects 0.000 abstract description 10
- 238000012545 processing Methods 0.000 description 48
- 238000003860 storage Methods 0.000 description 28
- 238000004422 calculation algorithm Methods 0.000 description 24
- 108091028043 Nucleic acid sequence Proteins 0.000 description 22
- 230000008569 process Effects 0.000 description 22
- 150000001413 amino acids Chemical class 0.000 description 17
- 238000012552 review Methods 0.000 description 17
- 241000700605 Viruses Species 0.000 description 15
- 241000282414 Homo sapiens Species 0.000 description 14
- 238000004891 communication Methods 0.000 description 13
- 238000004590 computer program Methods 0.000 description 11
- 231100000735 select agent Toxicity 0.000 description 10
- 230000002093 peripheral effect Effects 0.000 description 9
- 241000894006 Bacteria Species 0.000 description 8
- 238000013500 data storage Methods 0.000 description 8
- 208000001203 Smallpox Diseases 0.000 description 7
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 239000002773 nucleotide Substances 0.000 description 7
- 125000003729 nucleotide group Chemical group 0.000 description 7
- 230000007918 pathogenicity Effects 0.000 description 7
- 230000001105 regulatory effect Effects 0.000 description 7
- 208000010359 Newcastle Disease Diseases 0.000 description 6
- 238000010586 diagram Methods 0.000 description 6
- 238000007481 next generation sequencing Methods 0.000 description 6
- 238000011161 development Methods 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 101710154606 Hemagglutinin Proteins 0.000 description 4
- 241001157060 Lepiota brunneoincarnata Species 0.000 description 4
- 241000124008 Mammalia Species 0.000 description 4
- 101710093908 Outer capsid protein VP4 Proteins 0.000 description 4
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 4
- 101710176177 Protein A56 Proteins 0.000 description 4
- 238000013459 approach Methods 0.000 description 4
- 238000003491 array Methods 0.000 description 4
- 229910052799 carbon Inorganic materials 0.000 description 4
- 230000037406 food intake Effects 0.000 description 4
- 239000000185 hemagglutinin Substances 0.000 description 4
- 230000001717 pathogenic effect Effects 0.000 description 4
- 241000271566 Aves Species 0.000 description 3
- 241000233866 Fungi Species 0.000 description 3
- 241000238631 Hexapoda Species 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 241000870995 Variola Species 0.000 description 3
- 230000003044 adaptive effect Effects 0.000 description 3
- 230000000712 assembly Effects 0.000 description 3
- 238000000429 assembly Methods 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 230000033001 locomotion Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 244000052769 pathogen Species 0.000 description 3
- 238000002864 sequence alignment Methods 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 231100000765 toxin Toxicity 0.000 description 3
- 239000003053 toxin Substances 0.000 description 3
- 230000003612 virological effect Effects 0.000 description 3
- 230000000007 visual effect Effects 0.000 description 3
- 229920001621 AMOLED Polymers 0.000 description 2
- 241000283707 Capra Species 0.000 description 2
- 108020004414 DNA Proteins 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 241000700629 Orthopoxvirus Species 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 208000004756 Respiratory Insufficiency Diseases 0.000 description 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 2
- 206010046865 Vaccinia virus infection Diseases 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000003124 biologic agent Substances 0.000 description 2
- 238000004883 computer application Methods 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 229910003460 diamond Inorganic materials 0.000 description 2
- 239000010432 diamond Substances 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 239000004973 liquid crystal related substance Substances 0.000 description 2
- 238000003058 natural language processing Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 201000004193 respiratory failure Diseases 0.000 description 2
- 239000010979 ruby Substances 0.000 description 2
- 229910001750 ruby Inorganic materials 0.000 description 2
- 239000010454 slate Substances 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 2
- 238000013518 transcription Methods 0.000 description 2
- 230000035897 transcription Effects 0.000 description 2
- 238000013519 translation Methods 0.000 description 2
- 208000007089 vaccinia Diseases 0.000 description 2
- 201000006266 variola major Diseases 0.000 description 2
- 201000000627 variola minor Diseases 0.000 description 2
- 208000014016 variola minor infection Diseases 0.000 description 2
- 229930024421 Adenine Natural products 0.000 description 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
- 241000649667 Amanita arocheae Species 0.000 description 1
- 241000004343 Amanita bisporigera Species 0.000 description 1
- 241000052815 Amanita exitialis Species 0.000 description 1
- 241001050452 Amanita magnivelaris Species 0.000 description 1
- 241000649674 Amanita ocreata Species 0.000 description 1
- 241000171277 Amanita verna Species 0.000 description 1
- 241000238421 Arthropoda Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000282994 Cervidae Species 0.000 description 1
- 241001502567 Chikungunya virus Species 0.000 description 1
- 241000288673 Chiroptera Species 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- 241001237291 Clitocybe dealbata Species 0.000 description 1
- 108091035707 Consensus sequence Proteins 0.000 description 1
- 241000216151 Cortinarius gentilis Species 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 201000003075 Crimean-Congo hemorrhagic fever Diseases 0.000 description 1
- 241000938605 Crocodylia Species 0.000 description 1
- 208000001490 Dengue Diseases 0.000 description 1
- 206010012310 Dengue fever Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 241001115402 Ebolavirus Species 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 101001035951 Homo sapiens Hyaluronan-binding protein 2 Proteins 0.000 description 1
- 102100039238 Hyaluronan-binding protein 2 Human genes 0.000 description 1
- 241000712890 Junin mammarenavirus Species 0.000 description 1
- 241000712902 Lassa mammarenavirus Species 0.000 description 1
- 241000283986 Lepus Species 0.000 description 1
- 206010024641 Listeriosis Diseases 0.000 description 1
- 241000712898 Machupo mammarenavirus Species 0.000 description 1
- 241001115401 Marburgvirus Species 0.000 description 1
- 241000289419 Metatheria Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 241000588653 Neisseria Species 0.000 description 1
- 241000150452 Orthohantavirus Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 108010039491 Ricin Proteins 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 229960000643 adenine Drugs 0.000 description 1
- 238000013475 authorization Methods 0.000 description 1
- 206010064097 avian influenza Diseases 0.000 description 1
- 230000022131 cell cycle Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000009351 contact transmission Effects 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 229940104302 cytosine Drugs 0.000 description 1
- 238000013499 data model Methods 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 208000025729 dengue disease Diseases 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000005745 host immune response Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000000126 in silico method Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000010801 machine learning Methods 0.000 description 1
- 238000013178 mathematical model Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 231100000255 pathogenic effect Toxicity 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000005582 sexual transmission Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- WZWYJBNHTWCXIM-UHFFFAOYSA-N tenoxicam Chemical compound O=C1C=2SC=CC=2S(=O)(=O)N(C)C1=C(O)NC1=CC=CC=N1 WZWYJBNHTWCXIM-UHFFFAOYSA-N 0.000 description 1
- 229960002871 tenoxicam Drugs 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 229940113082 thymine Drugs 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 229940035893 uracil Drugs 0.000 description 1
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
- G16B30/10—Sequence alignment; Homology search
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1089—Design, preparation, screening or analysis of libraries using computer algorithms
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B15/00—Systems controlled by a computer
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
- G16B30/20—Sequence assembly
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
- G16B50/30—Data warehousing; Computing architectures
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B99/00—Subject matter not provided for in other groups of this subclass
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biophysics (AREA)
- Theoretical Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Evolutionary Biology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Bioethics (AREA)
- Databases & Information Systems (AREA)
- Library & Information Science (AREA)
- Automation & Control Theory (AREA)
- General Physics & Mathematics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Management, Administration, Business Operations System, And Electronic Commerce (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662348786P | 2016-06-10 | 2016-06-10 | |
| US62/348,786 | 2016-06-10 | ||
| US201662375858P | 2016-08-16 | 2016-08-16 | |
| US62/375,858 | 2016-08-16 | ||
| PCT/US2017/036868 WO2017214574A1 (en) | 2016-06-10 | 2017-06-09 | Systems and methods for automated annotation and screening of biological sequences |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3027127A1 true CA3027127A1 (en) | 2017-12-14 |
Family
ID=60574009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3027127A Pending CA3027127A1 (en) | 2016-06-10 | 2017-06-09 | Systems and methods for automated annotation and screening of biological sequences |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20170357752A1 (show.php) |
| EP (1) | EP3469499A4 (show.php) |
| JP (2) | JP2019523940A (show.php) |
| KR (1) | KR102476915B1 (show.php) |
| CN (1) | CN109564769A (show.php) |
| CA (1) | CA3027127A1 (show.php) |
| SG (1) | SG11201811025VA (show.php) |
| WO (1) | WO2017214574A1 (show.php) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4610368B1 (en) | 2013-08-05 | 2026-02-04 | Twist Bioscience Corporation | De novo synthesized gene libraries |
| WO2016126882A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
| US9981239B2 (en) | 2015-04-21 | 2018-05-29 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
| IL258164B (en) | 2015-09-18 | 2022-09-01 | Twist Bioscience Corp | Methods for modulating protein and cellular activity and method for nucleic acid synthesis |
| CN108698012A (zh) | 2015-09-22 | 2018-10-23 | 特韦斯特生物科学公司 | 用于核酸合成的柔性基底 |
| CN115920796A (zh) | 2015-12-01 | 2023-04-07 | 特韦斯特生物科学公司 | 功能化表面及其制备 |
| SG11201901563UA (en) | 2016-08-22 | 2019-03-28 | Twist Bioscience Corp | De novo synthesized nucleic acid libraries |
| JP6871364B2 (ja) | 2016-09-21 | 2021-05-12 | ツイスト バイオサイエンス コーポレーション | 核酸に基づくデータ保存 |
| AU2017378492B2 (en) | 2016-12-16 | 2022-06-16 | Twist Bioscience Corporation | Variant libraries of the immunological synapse and synthesis thereof |
| EP4556433A3 (en) | 2017-02-22 | 2025-08-06 | Twist Bioscience Corporation | Nucleic acid based data storage |
| WO2018170169A1 (en) | 2017-03-15 | 2018-09-20 | Twist Bioscience Corporation | Variant libraries of the immunological synapse and synthesis thereof |
| WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
| CN111566209B (zh) | 2017-06-12 | 2024-08-30 | 特韦斯特生物科学公司 | 无缝核酸装配方法 |
| EP3681906A4 (en) | 2017-09-11 | 2021-06-09 | Twist Bioscience Corporation | GPCR-BINDING PROTEINS AND THEIR SYNTHESIS |
| KR102889470B1 (ko) | 2017-10-20 | 2025-11-21 | 트위스트 바이오사이언스 코포레이션 | 폴리뉴클레오타이드 합성을 위한 가열된 나노웰 |
| CA3088911A1 (en) | 2018-01-04 | 2019-07-11 | Twist Bioscience Corporation | Dna-based storage device and method for synthesizing polynucleotides using the device |
| WO2019222706A1 (en) | 2018-05-18 | 2019-11-21 | Twist Bioscience Corporation | Polynucleotides, reagents, and methods for nucleic acid hybridization |
| EP3891280A4 (en) * | 2018-12-06 | 2022-08-10 | Battelle Memorial Institute | TECHNOLOGIES FOR NUCLEOTIDE SEQUENCE SCREENING |
| CA3124980A1 (en) | 2018-12-26 | 2020-07-02 | Twist Bioscience Corporation | Highly accurate de novo polynucleotide synthesis |
| JP2022521551A (ja) | 2019-02-26 | 2022-04-08 | ツイスト バイオサイエンス コーポレーション | Ｇｌｐ１受容体の変異体核酸ライブラリ |
| CN113785057A (zh) | 2019-02-26 | 2021-12-10 | 特韦斯特生物科学公司 | 用于抗体优化的变异核酸文库 |
| AU2020298294A1 (en) | 2019-06-21 | 2022-02-17 | Twist Bioscience Corporation | Barcode-based nucleic acid sequence assembly |
| US12091777B2 (en) | 2019-09-23 | 2024-09-17 | Twist Bioscience Corporation | Variant nucleic acid libraries for CRTH2 |
| WO2021061842A1 (en) | 2019-09-23 | 2021-04-01 | Twist Bioscience Corporation | Variant nucleic acid libraries for single domain antibodies |
| BR112022011235A2 (pt) | 2019-12-09 | 2022-12-13 | Twist Bioscience Corp | Bibliotecas de variantes de ácido nucleico para receptores de adenosina |
| EP4142739A2 (en) | 2020-04-27 | 2023-03-08 | Twist Bioscience Corporation | Variant nucleic acid libraries for coronavirus |
| CA3190667A1 (en) | 2020-08-26 | 2022-03-03 | Aaron Sato | Methods and compositions relating to glp1r variants |
| CA3190917A1 (en) | 2020-08-28 | 2022-03-03 | Andres Fernandez | Devices and methods for synthesis |
| WO2022086866A1 (en) | 2020-10-19 | 2022-04-28 | Twist Bioscience Corporation | Methods of synthesizing oligonucleotides using tethered nucleotides |
| EP4002383A3 (en) * | 2020-11-13 | 2022-08-03 | Tokyo Institute of Technology | Information processing device, information processing method, recording medium recording information processing program, and information processing system |
| KR20230147617A (ko) | 2021-01-21 | 2023-10-23 | 트위스트 바이오사이언스 코포레이션 | 아데노신 수용체에 관한 방법 및 조성물 |
| EP4314075A4 (en) | 2021-03-24 | 2025-04-09 | Twist Bioscience Corporation | VARIANT NUCLEIC ACID BANKS FOR CD3 |
| WO2022235584A1 (en) | 2021-05-03 | 2022-11-10 | Twist Bioscience Corporation | Variant nucleic acid libraries for glycans |
| US12201857B2 (en) | 2021-06-22 | 2025-01-21 | Twist Bioscience Corporation | Methods and compositions relating to covid antibody epitopes |
| US12571024B2 (en) | 2021-08-19 | 2026-03-10 | Twist Bioscience Corporation | Methods and compositions relating to covalently closed nucleic acids |
| EP4420127A4 (en) * | 2021-10-19 | 2025-09-17 | Battelle Memorial Institute | GENETIC ENGINEERING DETECTION TECHNOLOGIES |
| KR20240101677A9 (ko) | 2021-11-18 | 2025-12-10 | 트위스트 바이오사이언스 코포레이션 | Dickkopf-1 변이체 항체 및 사용 방법 |
| US12325739B2 (en) | 2022-01-03 | 2025-06-10 | Twist Bioscience Corporation | Bispecific SARS-CoV-2 antibodies and methods of use |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5701256A (en) * | 1995-05-31 | 1997-12-23 | Cold Spring Harbor Laboratory | Method and apparatus for biological sequence comparison |
| DE50015858D1 (de) * | 1999-02-19 | 2010-03-18 | Febit Holding Gmbh | Verfahren zur Herstellung von Polymeren |
| CA2577741A1 (en) * | 2004-08-18 | 2006-03-02 | Abbott Molecular, Inc. | Determining data quality and/or segmental aneusomy using a computer system |
| US8808986B2 (en) * | 2008-08-27 | 2014-08-19 | Gen9, Inc. | Methods and devices for high fidelity polynucleotide synthesis |
| US20100292102A1 (en) * | 2009-05-14 | 2010-11-18 | Ali Nouri | System and Method For Preventing Synthesis of Dangerous Biological Sequences |
| WO2012168815A2 (en) * | 2011-06-06 | 2012-12-13 | Koninklijke Philips Electronics N.V. | Method for assembly of nucleic acid sequence data |
| US20150120265A1 (en) * | 2011-09-01 | 2015-04-30 | Genome Compiler Corporation | System for polynucleotide construct design, visualization and transactions to manufacture the same |
| CN104871164B (zh) * | 2012-10-24 | 2019-02-05 | 南托米克斯有限责任公司 | 处理和呈现基因组序列数据中核苷酸变化的基因组浏览器系统 |
| EP4610368B1 (en) * | 2013-08-05 | 2026-02-04 | Twist Bioscience Corporation | De novo synthesized gene libraries |
-
2017
- 2017-06-09 CN CN201780048980.4A patent/CN109564769A/zh active Pending
- 2017-06-09 EP EP17811124.1A patent/EP3469499A4/en not_active Withdrawn
- 2017-06-09 JP JP2018563706A patent/JP2019523940A/ja active Pending
- 2017-06-09 WO PCT/US2017/036868 patent/WO2017214574A1/en not_active Ceased
- 2017-06-09 KR KR1020197000811A patent/KR102476915B1/ko active Active
- 2017-06-09 SG SG11201811025VA patent/SG11201811025VA/en unknown
- 2017-06-09 US US15/619,322 patent/US20170357752A1/en not_active Abandoned
- 2017-06-09 CA CA3027127A patent/CA3027127A1/en active Pending
-
2022
- 2022-09-07 JP JP2022142326A patent/JP2022181213A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20190017932A (ko) | 2019-02-20 |
| EP3469499A1 (en) | 2019-04-17 |
| JP2022181213A (ja) | 2022-12-07 |
| JP2019523940A (ja) | 2019-08-29 |
| EP3469499A4 (en) | 2020-10-21 |
| KR102476915B1 (ko) | 2022-12-12 |
| WO2017214574A1 (en) | 2017-12-14 |
| US20170357752A1 (en) | 2017-12-14 |
| CN109564769A (zh) | 2019-04-02 |
| SG11201811025VA (en) | 2019-01-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR102476915B1 (ko) | 생물학적 서열의 자동화된 주석달기 및 스크리닝을 위한 시스템 및 방법 | |
| Tesson et al. | A comprehensive resource for exploring antiphage defense: DefenseFinder webservice, wiki and databases | |
| Narzisi et al. | Comparing de novo genome assembly: the long and short of it | |
| McGibbon et al. | MDTraj: a modern open library for the analysis of molecular dynamics trajectories | |
| US20210319907A1 (en) | Multi-omic search engine for integrative analysis of cancer genomic and clinical data | |
| US20200299684A1 (en) | Systems and methods for polynucleotide scoring | |
| Glusman et al. | Mapping genetic variations to three-dimensional protein structures to enhance variant interpretation: a proposed framework | |
| Tang et al. | SynFind: compiling syntenic regions across any set of genomes on demand | |
| Simonyan et al. | High-performance integrated virtual environment (HIVE) tools and applications for big data analysis | |
| Priyadarshini et al. | Genome-based approaches to develop epitope-driven subunit vaccines against pathogens of infective endocarditis | |
| EP3063688A1 (en) | Visualization, sharing and analysis of large data sets | |
| Partin et al. | Learning curves for drug response prediction in cancer cell lines | |
| Edmunds et al. | Experiences in integrated data and research object publishing using GigaDB | |
| Vidanagamachchi et al. | Opportunities, challenges and future perspectives of using bioinformatics and artificial intelligence techniques on tropical disease identification using omics data | |
| Chen et al. | Extension of SEIR compartmental models for constructive Lyapunov control of COVID-19 and analysis in terms of practical stability | |
| Pathak et al. | FisOmics: A portal of fish genomic resources | |
| Lvovs et al. | Balancing ethical data sharing and open science for reproducible research in biomedical data science | |
| US12512209B2 (en) | Systems and methods for medical imaging gateways | |
| Ahmed | Genomics and bioinformatics: integrating data for better genetic insights | |
| Xu et al. | e3SIM: epidemiological-ecological-evolutionary simulation framework for genomic epidemiology | |
| Holsten et al. | hCoCena: A toolbox for network-based co-expression analysis and horizontal integration of transcriptomic datasets | |
| Kumar et al. | AGeS: a software system for microbial genome sequence annotation | |
| Knoben et al. | Improving performance of hardware accelerators by optimizing data movement: A bioinformatics case study | |
| Cheng et al. | PyNCBIminer: A platform for assembling phylogenetic data sets via GenBank datamining | |
| Radig et al. | Tracking biological hallucinations in single-cell perturbation predictions using scArchon, a comprehensive benchmarking platform |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20220519 |
|
| EEER | Examination request |
Effective date: 20220519 |
|
| EEER | Examination request |
Effective date: 20220519 |
|
| EEER | Examination request |
Effective date: 20220519 |
|
| EEER | Examination request |
Effective date: 20220519 |