CA3023223A1 - Systemes, dispositifs et procedes medicaux de reseaux de pixels - Google Patents
Systemes, dispositifs et procedes medicaux de reseaux de pixels Download PDFInfo
- Publication number
- CA3023223A1 CA3023223A1 CA3023223A CA3023223A CA3023223A1 CA 3023223 A1 CA3023223 A1 CA 3023223A1 CA 3023223 A CA3023223 A CA 3023223A CA 3023223 A CA3023223 A CA 3023223A CA 3023223 A1 CA3023223 A1 CA 3023223A1
- Authority
- CA
- Canada
- Prior art keywords
- skin
- scalpet
- site
- composition
- dermal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims abstract description 380
- 230000002500 effect on skin Effects 0.000 claims abstract description 282
- 238000003306 harvesting Methods 0.000 claims abstract description 130
- 239000000945 filler Substances 0.000 claims abstract description 120
- 239000000203 mixture Substances 0.000 claims abstract description 106
- 210000002615 epidermis Anatomy 0.000 claims abstract description 86
- 210000003491 skin Anatomy 0.000 claims description 751
- 238000002271 resection Methods 0.000 claims description 349
- 230000007547 defect Effects 0.000 claims description 112
- 238000002347 injection Methods 0.000 claims description 103
- 239000007924 injection Substances 0.000 claims description 103
- 230000001464 adherent effect Effects 0.000 claims description 94
- 231100000241 scar Toxicity 0.000 claims description 91
- 210000004207 dermis Anatomy 0.000 claims description 62
- 210000001519 tissue Anatomy 0.000 claims description 59
- 238000005520 cutting process Methods 0.000 claims description 57
- 239000000758 substrate Substances 0.000 claims description 40
- 230000000994 depressogenic effect Effects 0.000 claims description 23
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 22
- 239000011159 matrix material Substances 0.000 claims description 21
- 238000002156 mixing Methods 0.000 claims description 21
- 239000012530 fluid Substances 0.000 claims description 16
- 238000011068 loading method Methods 0.000 claims description 16
- 238000010008 shearing Methods 0.000 claims description 15
- 210000002950 fibroblast Anatomy 0.000 claims description 14
- 239000011780 sodium chloride Substances 0.000 claims description 14
- 210000004872 soft tissue Anatomy 0.000 claims description 14
- 230000002093 peripheral effect Effects 0.000 claims description 13
- 239000012867 bioactive agent Substances 0.000 claims description 12
- 230000033001 locomotion Effects 0.000 claims description 11
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 10
- 239000000499 gel Substances 0.000 claims description 10
- 229920002674 hyaluronan Polymers 0.000 claims description 10
- 229960003160 hyaluronic acid Drugs 0.000 claims description 10
- 210000001260 vocal cord Anatomy 0.000 claims description 10
- 230000003444 anaesthetic effect Effects 0.000 claims description 9
- 230000037303 wrinkles Effects 0.000 claims description 9
- 230000015572 biosynthetic process Effects 0.000 claims description 8
- 230000008878 coupling Effects 0.000 claims description 8
- 238000010168 coupling process Methods 0.000 claims description 8
- 238000005859 coupling reaction Methods 0.000 claims description 8
- 239000000017 hydrogel Substances 0.000 claims description 8
- 210000005070 sphincter Anatomy 0.000 claims description 8
- 239000003102 growth factor Substances 0.000 claims description 7
- 230000000472 traumatic effect Effects 0.000 claims description 7
- 239000012080 ambient air Substances 0.000 claims description 6
- 206010033675 panniculitis Diseases 0.000 claims description 6
- 210000004304 subcutaneous tissue Anatomy 0.000 claims description 6
- 210000003708 urethra Anatomy 0.000 claims description 6
- 210000004379 membrane Anatomy 0.000 description 110
- 239000012528 membrane Substances 0.000 description 110
- 210000004209 hair Anatomy 0.000 description 90
- 238000011282 treatment Methods 0.000 description 58
- 208000032170 Congenital Abnormalities Diseases 0.000 description 52
- 230000037390 scarring Effects 0.000 description 49
- 239000010410 layer Substances 0.000 description 35
- 239000000853 adhesive Substances 0.000 description 31
- 230000001070 adhesive effect Effects 0.000 description 31
- 201000010251 cutis laxa Diseases 0.000 description 31
- 210000004761 scalp Anatomy 0.000 description 31
- 238000003032 molecular docking Methods 0.000 description 28
- 230000009467 reduction Effects 0.000 description 28
- 230000029663 wound healing Effects 0.000 description 28
- 238000002316 cosmetic surgery Methods 0.000 description 27
- 230000035876 healing Effects 0.000 description 26
- 238000007443 liposuction Methods 0.000 description 26
- 239000013598 vector Substances 0.000 description 25
- 230000004044 response Effects 0.000 description 23
- 230000008569 process Effects 0.000 description 22
- 238000002054 transplantation Methods 0.000 description 20
- 102000008186 Collagen Human genes 0.000 description 19
- 108010035532 Collagen Proteins 0.000 description 19
- 238000013459 approach Methods 0.000 description 18
- 229920001436 collagen Polymers 0.000 description 18
- 238000012377 drug delivery Methods 0.000 description 18
- 230000006870 function Effects 0.000 description 18
- 210000000481 breast Anatomy 0.000 description 17
- 239000003589 local anesthetic agent Substances 0.000 description 17
- 238000001356 surgical procedure Methods 0.000 description 16
- 238000012546 transfer Methods 0.000 description 16
- PPTYJKAXVCCBDU-UHFFFAOYSA-N Rohypnol Chemical compound N=1CC(=O)N(C)C2=CC=C([N+]([O-])=O)C=C2C=1C1=CC=CC=C1F PPTYJKAXVCCBDU-UHFFFAOYSA-N 0.000 description 15
- 230000007246 mechanism Effects 0.000 description 15
- 230000036961 partial effect Effects 0.000 description 15
- 210000004003 subcutaneous fat Anatomy 0.000 description 15
- 201000004384 Alopecia Diseases 0.000 description 14
- 210000003484 anatomy Anatomy 0.000 description 14
- 238000007906 compression Methods 0.000 description 14
- 230000006835 compression Effects 0.000 description 14
- 239000003814 drug Substances 0.000 description 14
- 210000003780 hair follicle Anatomy 0.000 description 14
- 230000003111 delayed effect Effects 0.000 description 13
- 230000008021 deposition Effects 0.000 description 13
- 230000000694 effects Effects 0.000 description 13
- 230000002829 reductive effect Effects 0.000 description 13
- 208000027418 Wounds and injury Diseases 0.000 description 12
- 229940079593 drug Drugs 0.000 description 12
- 208000014674 injury Diseases 0.000 description 12
- 208000032544 Cicatrix Diseases 0.000 description 11
- 206010049287 Lipodystrophy acquired Diseases 0.000 description 11
- 230000008602 contraction Effects 0.000 description 11
- 230000006378 damage Effects 0.000 description 11
- 238000001125 extrusion Methods 0.000 description 11
- 208000006132 lipodystrophy Diseases 0.000 description 11
- 230000002980 postoperative effect Effects 0.000 description 11
- 230000037387 scars Effects 0.000 description 11
- 238000007920 subcutaneous administration Methods 0.000 description 11
- 206010029113 Neovascularisation Diseases 0.000 description 10
- 230000008901 benefit Effects 0.000 description 10
- 230000035800 maturation Effects 0.000 description 10
- 210000005195 occipital scalp Anatomy 0.000 description 10
- 239000007787 solid Substances 0.000 description 10
- 206010052428 Wound Diseases 0.000 description 9
- 238000003491 array Methods 0.000 description 9
- 238000005096 rolling process Methods 0.000 description 9
- 230000008733 trauma Effects 0.000 description 9
- 230000035899 viability Effects 0.000 description 9
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 8
- 239000002131 composite material Substances 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 210000000689 upper leg Anatomy 0.000 description 8
- 206010039580 Scar Diseases 0.000 description 7
- 208000002847 Surgical Wound Diseases 0.000 description 7
- 210000001015 abdomen Anatomy 0.000 description 7
- 231100000360 alopecia Toxicity 0.000 description 7
- 206010068168 androgenetic alopecia Diseases 0.000 description 7
- 230000001413 cellular effect Effects 0.000 description 7
- 230000000729 hypotrophic effect Effects 0.000 description 7
- 210000003127 knee Anatomy 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 230000002035 prolonged effect Effects 0.000 description 7
- 238000004904 shortening Methods 0.000 description 7
- 206010041235 Snoring Diseases 0.000 description 6
- 238000000605 extraction Methods 0.000 description 6
- 238000007726 management method Methods 0.000 description 6
- 239000000049 pigment Substances 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 230000006641 stabilisation Effects 0.000 description 6
- 238000011105 stabilization Methods 0.000 description 6
- 230000007704 transition Effects 0.000 description 6
- 210000000617 arm Anatomy 0.000 description 5
- 210000001217 buttock Anatomy 0.000 description 5
- 230000003902 lesion Effects 0.000 description 5
- 230000000670 limiting effect Effects 0.000 description 5
- 238000013507 mapping Methods 0.000 description 5
- 230000010534 mechanism of action Effects 0.000 description 5
- 230000035515 penetration Effects 0.000 description 5
- 201000002859 sleep apnea Diseases 0.000 description 5
- 210000001584 soft palate Anatomy 0.000 description 5
- 230000003068 static effect Effects 0.000 description 5
- 210000000434 stratum corneum Anatomy 0.000 description 5
- 238000012384 transportation and delivery Methods 0.000 description 5
- 206010002091 Anaesthesia Diseases 0.000 description 4
- 206010006802 Burns second degree Diseases 0.000 description 4
- 208000035484 Cellulite Diseases 0.000 description 4
- 206010015150 Erythema Diseases 0.000 description 4
- 206010021639 Incontinence Diseases 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 4
- 206010049752 Peau d'orange Diseases 0.000 description 4
- 238000002679 ablation Methods 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 230000009471 action Effects 0.000 description 4
- 230000004913 activation Effects 0.000 description 4
- 230000037005 anaesthesia Effects 0.000 description 4
- 230000003698 anagen phase Effects 0.000 description 4
- 238000007486 appendectomy Methods 0.000 description 4
- 210000001099 axilla Anatomy 0.000 description 4
- 238000001574 biopsy Methods 0.000 description 4
- 230000036232 cellulite Effects 0.000 description 4
- 238000011109 contamination Methods 0.000 description 4
- 238000012937 correction Methods 0.000 description 4
- 238000011161 development Methods 0.000 description 4
- 230000018109 developmental process Effects 0.000 description 4
- 230000002496 gastric effect Effects 0.000 description 4
- 229960001340 histamine Drugs 0.000 description 4
- 230000007774 longterm Effects 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 210000004877 mucosa Anatomy 0.000 description 4
- 210000003205 muscle Anatomy 0.000 description 4
- 230000036407 pain Effects 0.000 description 4
- 238000011084 recovery Methods 0.000 description 4
- 230000000638 stimulation Effects 0.000 description 4
- 230000000699 topical effect Effects 0.000 description 4
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 3
- 229930182837 (R)-adrenaline Natural products 0.000 description 3
- 206010003694 Atrophy Diseases 0.000 description 3
- 206010006803 Burns third degree Diseases 0.000 description 3
- 206010010356 Congenital anomaly Diseases 0.000 description 3
- 206010015995 Eyelid ptosis Diseases 0.000 description 3
- 102000018997 Growth Hormone Human genes 0.000 description 3
- 108010051696 Growth Hormone Proteins 0.000 description 3
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 3
- 208000012287 Prolapse Diseases 0.000 description 3
- 210000001789 adipocyte Anatomy 0.000 description 3
- 210000000577 adipose tissue Anatomy 0.000 description 3
- 230000037444 atrophy Effects 0.000 description 3
- 210000001142 back Anatomy 0.000 description 3
- 230000004888 barrier function Effects 0.000 description 3
- 230000036770 blood supply Effects 0.000 description 3
- 230000001010 compromised effect Effects 0.000 description 3
- 208000006111 contracture Diseases 0.000 description 3
- 230000001351 cycling effect Effects 0.000 description 3
- 230000005670 electromagnetic radiation Effects 0.000 description 3
- 229960005139 epinephrine Drugs 0.000 description 3
- 231100000321 erythema Toxicity 0.000 description 3
- 210000000416 exudates and transudate Anatomy 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 238000009499 grossing Methods 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 239000000122 growth hormone Substances 0.000 description 3
- 230000003779 hair growth Effects 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 230000001969 hypertrophic effect Effects 0.000 description 3
- 230000001900 immune effect Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000036210 malignancy Effects 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 230000037311 normal skin Effects 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 201000003004 ptosis Diseases 0.000 description 3
- 230000008439 repair process Effects 0.000 description 3
- 206010040882 skin lesion Diseases 0.000 description 3
- 231100000444 skin lesion Toxicity 0.000 description 3
- 125000006850 spacer group Chemical group 0.000 description 3
- 229940072358 xylocaine Drugs 0.000 description 3
- 206010006797 Burns first degree Diseases 0.000 description 2
- 206010051814 Eschar Diseases 0.000 description 2
- 206010063560 Excessive granulation tissue Diseases 0.000 description 2
- 206010064503 Excessive skin Diseases 0.000 description 2
- 241001313288 Labia Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 206010062575 Muscle contracture Diseases 0.000 description 2
- 208000000453 Skin Neoplasms Diseases 0.000 description 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
- 206010067775 Upper airway obstruction Diseases 0.000 description 2
- 230000003187 abdominal effect Effects 0.000 description 2
- 230000002745 absorbent Effects 0.000 description 2
- 239000002250 absorbent Substances 0.000 description 2
- 230000001944 accentuation Effects 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 239000003570 air Substances 0.000 description 2
- 230000003466 anti-cipated effect Effects 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 230000036621 balding Effects 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000007012 clinical effect Effects 0.000 description 2
- 238000005056 compaction Methods 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 238000001804 debridement Methods 0.000 description 2
- 230000032798 delamination Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000013536 elastomeric material Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 210000001339 epidermal cell Anatomy 0.000 description 2
- 231100000333 eschar Toxicity 0.000 description 2
- 230000000763 evoking effect Effects 0.000 description 2
- 210000001723 extracellular space Anatomy 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 208000021302 gastroesophageal reflux disease Diseases 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- 230000002068 genetic effect Effects 0.000 description 2
- 210000001126 granulation tissue Anatomy 0.000 description 2
- 210000003128 head Anatomy 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 210000003630 histaminocyte Anatomy 0.000 description 2
- 230000000642 iatrogenic effect Effects 0.000 description 2
- 230000003116 impacting effect Effects 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 230000001788 irregular Effects 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 230000004130 lipolysis Effects 0.000 description 2
- 238000005461 lubrication Methods 0.000 description 2
- 238000001000 micrograph Methods 0.000 description 2
- 230000005012 migration Effects 0.000 description 2
- 238000013508 migration Methods 0.000 description 2
- 230000000394 mitotic effect Effects 0.000 description 2
- 210000000651 myofibroblast Anatomy 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 230000000750 progressive effect Effects 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000003716 rejuvenation Effects 0.000 description 2
- 238000007634 remodeling Methods 0.000 description 2
- 230000000284 resting effect Effects 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 210000001732 sebaceous gland Anatomy 0.000 description 2
- 230000036548 skin texture Effects 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 210000004243 sweat Anatomy 0.000 description 2
- 210000000106 sweat gland Anatomy 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 230000003797 telogen phase Effects 0.000 description 2
- 230000028016 temperature homeostasis Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 230000008719 thickening Effects 0.000 description 2
- 238000011269 treatment regimen Methods 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 229940025573 xylocaine with epinephrine Drugs 0.000 description 2
- 206010063659 Aversion Diseases 0.000 description 1
- 208000021657 Birth injury Diseases 0.000 description 1
- 206010004954 Birth trauma Diseases 0.000 description 1
- 208000035985 Body Odor Diseases 0.000 description 1
- 108030001720 Bontoxilysin Proteins 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 108010068426 Contractile Proteins Proteins 0.000 description 1
- 102000002585 Contractile Proteins Human genes 0.000 description 1
- NOQGZXFMHARMLW-UHFFFAOYSA-N Daminozide Chemical compound CN(C)NC(=O)CCC(O)=O NOQGZXFMHARMLW-UHFFFAOYSA-N 0.000 description 1
- 208000034423 Delivery Diseases 0.000 description 1
- 206010012426 Dermal cyst Diseases 0.000 description 1
- 206010056340 Diabetic ulcer Diseases 0.000 description 1
- 206010013952 Dysphonia Diseases 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 206010062016 Immunosuppression Diseases 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 208000035901 Ischaemic ulcer Diseases 0.000 description 1
- 208000034693 Laceration Diseases 0.000 description 1
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 206010029098 Neoplasm skin Diseases 0.000 description 1
- 208000007256 Nevus Diseases 0.000 description 1
- 208000006787 Port-Wine Stain Diseases 0.000 description 1
- 208000004550 Postoperative Pain Diseases 0.000 description 1
- 206010067171 Regurgitation Diseases 0.000 description 1
- 206010039897 Sedation Diseases 0.000 description 1
- 206010040844 Skin exfoliation Diseases 0.000 description 1
- 206010040888 Skin malformation Diseases 0.000 description 1
- 206010040904 Skin odour abnormal Diseases 0.000 description 1
- 206010040925 Skin striae Diseases 0.000 description 1
- 206010066218 Stress Urinary Incontinence Diseases 0.000 description 1
- 108010057266 Type A Botulinum Toxins Proteins 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010046543 Urinary incontinence Diseases 0.000 description 1
- 208000000558 Varicose Ulcer Diseases 0.000 description 1
- 206010047139 Vasoconstriction Diseases 0.000 description 1
- 210000001766 X chromosome Anatomy 0.000 description 1
- 108700029631 X-Linked Genes Proteins 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000004873 anchoring Methods 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000008365 aqueous carrier Substances 0.000 description 1
- 230000003416 augmentation Effects 0.000 description 1
- 230000037365 barrier function of the epidermis Effects 0.000 description 1
- 210000002469 basement membrane Anatomy 0.000 description 1
- 238000003287 bathing Methods 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 229940089093 botox Drugs 0.000 description 1
- 229940053031 botulinum toxin Drugs 0.000 description 1
- 238000005219 brazing Methods 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 229960001334 corticosteroids Drugs 0.000 description 1
- 238000002788 crimping Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000035614 depigmentation Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000035618 desquamation Effects 0.000 description 1
- 238000007907 direct compression Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 210000005069 ears Anatomy 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 208000017338 epidermoid cysts Diseases 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 210000001097 facial muscle Anatomy 0.000 description 1
- 201000000475 female stress incontinence Diseases 0.000 description 1
- 210000003754 fetus Anatomy 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 229960004039 finasteride Drugs 0.000 description 1
- DBEPLOCGEIEOCV-WSBQPABSSA-N finasteride Chemical compound N([C@@H]1CC2)C(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)NC(C)(C)C)[C@@]2(C)CC1 DBEPLOCGEIEOCV-WSBQPABSSA-N 0.000 description 1
- 230000003325 follicular Effects 0.000 description 1
- 210000005200 frontal scalp Anatomy 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 210000004013 groin Anatomy 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000003648 hair appearance Effects 0.000 description 1
- 210000004919 hair shaft Anatomy 0.000 description 1
- 238000002683 hand surgery Methods 0.000 description 1
- 208000002557 hidradenitis Diseases 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000002690 local anesthesia Methods 0.000 description 1
- 229960005015 local anesthetics Drugs 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 206010025135 lupus erythematosus Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 210000002752 melanocyte Anatomy 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 229960003632 minoxidil Drugs 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 210000005199 parietal scalp Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 238000000059 patterning Methods 0.000 description 1
- 230000037368 penetrate the skin Effects 0.000 description 1
- 239000002831 pharmacologic agent Substances 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 238000013439 planning Methods 0.000 description 1
- 230000035752 proliferative phase Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 230000002784 sclerotic effect Effects 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 230000036280 sedation Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000009958 sewing Methods 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 230000036558 skin tension Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 208000022170 stress incontinence Diseases 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 238000010408 sweeping Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 231100000057 systemic toxicity Toxicity 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 230000009772 tissue formation Effects 0.000 description 1
- 229940126702 topical medication Drugs 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 210000001944 turbinate Anatomy 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 230000009677 vaginal delivery Effects 0.000 description 1
- 230000025033 vasoconstriction Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000009941 weaving Methods 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
- 230000010388 wound contraction Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/32—Surgical cutting instruments
- A61B17/322—Skin grafting apparatus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/362—Skin, e.g. dermal papillae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
- A61B17/205—Vaccinating by means of needles or other puncturing devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/32—Surgical cutting instruments
- A61B17/320068—Surgical cutting instruments using mechanical vibrations, e.g. ultrasonic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/32—Surgical cutting instruments
- A61B17/3205—Excision instruments
- A61B17/32053—Punch like cutting instruments, e.g. using a cylindrical or oval knife
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00747—Dermatology
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00747—Dermatology
- A61B2017/00752—Hair removal or transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00747—Dermatology
- A61B2017/00761—Removing layer of skin tissue, e.g. wrinkles, scars or cancerous tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00792—Plastic surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00796—Breast surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/32—Surgical cutting instruments
- A61B17/322—Skin grafting apparatus
- A61B2017/3225—Skin grafting apparatus with processing of harvested tissue
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Surgery (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical & Material Sciences (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Medicinal Chemistry (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Hematology (AREA)
- Dentistry (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Mechanical Engineering (AREA)
- Surgical Instruments (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Control Of Indicators Other Than Cathode Ray Tubes (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
L'invention concerne des systèmes, des instruments, des procédés et des compositions impliquant l'élimination d'une partie de l'épiderme à l'intérieur d'un site donneur sur un sujet, et la collecte de bouchons dermiques à l'intérieur du site donneur. Une charge injectable est formée par hachage des bouchons dermiques. La charge injectable est conçue pour être injectée dans un site receveur sur le sujet.
Applications Claiming Priority (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662331076P | 2016-05-03 | 2016-05-03 | |
US62/331,076 | 2016-05-03 | ||
US201762456775P | 2017-02-09 | 2017-02-09 | |
US62/456,775 | 2017-02-09 | ||
US15/431,230 | 2017-02-13 | ||
US15/431,230 US11109887B2 (en) | 2013-12-06 | 2017-02-13 | Pixel array medical systems, devices and methods |
US15/431,247 US10368904B2 (en) | 2013-12-06 | 2017-02-13 | Pixel array medical systems, devices and methods |
US15/431,247 | 2017-02-13 | ||
US201762481391P | 2017-04-04 | 2017-04-04 | |
US62/481,391 | 2017-04-04 | ||
PCT/US2017/030840 WO2017192723A1 (fr) | 2016-05-03 | 2017-05-03 | Systèmes, dispositifs et procédés médicaux de réseaux de pixels |
Publications (1)
Publication Number | Publication Date |
---|---|
CA3023223A1 true CA3023223A1 (fr) | 2017-11-09 |
Family
ID=60203289
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA3023223A Pending CA3023223A1 (fr) | 2016-05-03 | 2017-05-03 | Systemes, dispositifs et procedes medicaux de reseaux de pixels |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP3451951A4 (fr) |
JP (2) | JP2019515750A (fr) |
KR (1) | KR102448313B1 (fr) |
CN (1) | CN110312482B (fr) |
AU (1) | AU2017261273A1 (fr) |
BR (1) | BR112018072717A2 (fr) |
CA (1) | CA3023223A1 (fr) |
SG (1) | SG11201809824VA (fr) |
WO (1) | WO2017192723A1 (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11103275B2 (en) * | 2010-12-17 | 2021-08-31 | Srgi Holdings, Llc | Pixel array medical systems, devices and methods |
WO2014130359A1 (fr) | 2013-02-20 | 2014-08-28 | Cytrellis Biosystems, Inc. | Procédés et dispositifs pour le resserrement de la peau |
KR20220010055A (ko) | 2013-08-09 | 2022-01-25 | 사이트렐리스 바이오시스템즈, 인크. | 비-열적 조직 절제를 사용한 피부 치료를 위한 방법 및 기구 |
EP3082897A4 (fr) | 2013-12-19 | 2017-07-26 | Cytrellis Biosystems, Inc. | Procédés et dispositifs pour manipuler la graisse sous-cutanée |
CA2967636A1 (fr) | 2014-11-14 | 2016-05-19 | Cytrellis Biosystems, Inc. | Dispositifs et procedes pour l'ablation de la peau |
US11564706B2 (en) * | 2019-10-28 | 2023-01-31 | Srgi Holdings, Llc | Pixel array medical systems, devices and methods |
JP6968867B2 (ja) | 2016-03-29 | 2021-11-17 | サイトレリス バイオシステムズ,インコーポレーテッド | 美容用スキンリサーフェシングのためのデバイス及び方法 |
EP3515323A4 (fr) | 2016-09-21 | 2020-06-10 | Cytrellis Biosystems, Inc. | Dispositifs et méthodes de restructuration cosmétique de la peau |
WO2020223492A1 (fr) * | 2019-04-30 | 2020-11-05 | Srgi Holdings Llc | Systèmes, dispositifs et procédés médicaux à réseau de pixels |
US20210038389A1 (en) * | 2019-08-06 | 2021-02-11 | Boston Scientific Scimed, Inc. | Adhesive penile construction template and urethra scaffold tube for neophallus surgery |
EP4312800A1 (fr) * | 2021-03-22 | 2024-02-07 | The General Hospital Corporation | Charge injectable provenant de derme autologue sans cicatrice du donneur |
CN114010163B (zh) * | 2021-12-02 | 2023-12-19 | 中国中医科学院医学实验中心 | 基于光学成像的表皮细胞迁移定位系统及方法 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4582640A (en) * | 1982-03-08 | 1986-04-15 | Collagen Corporation | Injectable cross-linked collagen implant material |
US4476864A (en) * | 1982-09-29 | 1984-10-16 | Jirayr Tezel | Combined multiple punch and single punch hair transplant cutting device |
GB0017999D0 (en) * | 2000-07-21 | 2000-09-13 | Smithkline Beecham Biolog | Novel device |
KR100512694B1 (ko) * | 2001-11-17 | 2005-09-08 | (주)에이치비메디컬스 | 모발이식 장치 |
EP1627662B1 (fr) * | 2004-06-10 | 2011-03-02 | Candela Corporation | Appareil pour le traitement de la peau à l'aide d'une source lumineuse assistée par dépression |
WO2004075764A1 (fr) * | 2003-02-27 | 2004-09-10 | Applied Tissue Technologies Llc | Methode et appareil de traitement de tissu cutane |
US7316822B2 (en) * | 2003-11-26 | 2008-01-08 | Ethicon, Inc. | Conformable tissue repair implant capable of injection delivery |
WO2008148071A2 (fr) * | 2007-05-24 | 2008-12-04 | Nidus2, Llc | Derme injectable |
CN101088569A (zh) * | 2007-07-24 | 2007-12-19 | 北京赛尔泰和生物医药科技有限公司 | 一种注射用人体皮肤填充剂及其制备方法 |
WO2009126556A1 (fr) * | 2008-04-08 | 2009-10-15 | Glycomimetics, Inc. | Inhibiteur de pan-sélectine avec activité pharmacocinétique améliorée |
US8486155B2 (en) * | 2010-05-13 | 2013-07-16 | Ethicon Endo-Surgery, Inc. | Fistula repair plug having multiple layers |
US8926631B2 (en) * | 2010-08-06 | 2015-01-06 | MoMelan Technologies, Inc. | Methods for preparing a skin graft without culturing or use of biologics |
US9597111B2 (en) * | 2010-08-06 | 2017-03-21 | Kci Licensing, Inc. | Methods for applying a skin graft |
WO2012145504A1 (fr) * | 2011-04-20 | 2012-10-26 | Kci Licensing, Inc. | Dispositifs et procédés de greffe cutanée |
AU2012326209B2 (en) * | 2011-10-17 | 2015-12-17 | Pilofocus, Inc. | Hair restoration |
US9162011B2 (en) * | 2011-12-19 | 2015-10-20 | Allosource | Flowable matrix compositions and methods |
EP2928395B1 (fr) * | 2012-12-06 | 2022-02-02 | SRGI Holdings LLC | Dispositifs médicaux à réseau de pixels |
CN103234962A (zh) * | 2013-05-09 | 2013-08-07 | 董建国 | 一种阴道微生态环境传感器及其制作方法 |
WO2015051164A2 (fr) * | 2013-10-02 | 2015-04-09 | Srgi Holdings, Llc | Dispositifs et procédés médicaux à réseau de pixels |
KR102382212B1 (ko) * | 2013-10-02 | 2022-04-04 | 에스알쥐아이 홀딩스 엘엘씨 | 픽셀 어레이 의료용 장치 및 방법 |
JP2017528216A (ja) * | 2014-08-29 | 2017-09-28 | エスアールジーアイ ホールディングス エルエルシーSrgi Holdings Llc | ピクセルアレイ医療デバイスおよび方法 |
-
2017
- 2017-05-03 WO PCT/US2017/030840 patent/WO2017192723A1/fr unknown
- 2017-05-03 SG SG11201809824VA patent/SG11201809824VA/en unknown
- 2017-05-03 JP JP2018558222A patent/JP2019515750A/ja active Pending
- 2017-05-03 CA CA3023223A patent/CA3023223A1/fr active Pending
- 2017-05-03 BR BR112018072717-2A patent/BR112018072717A2/pt not_active IP Right Cessation
- 2017-05-03 KR KR1020187034950A patent/KR102448313B1/ko active IP Right Grant
- 2017-05-03 AU AU2017261273A patent/AU2017261273A1/en not_active Abandoned
- 2017-05-03 EP EP17793252.2A patent/EP3451951A4/fr not_active Withdrawn
- 2017-05-03 CN CN201780034332.3A patent/CN110312482B/zh not_active Expired - Fee Related
-
2022
- 2022-12-06 JP JP2022194752A patent/JP2023027177A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2017192723A1 (fr) | 2017-11-09 |
EP3451951A1 (fr) | 2019-03-13 |
CN110312482B (zh) | 2022-09-13 |
JP2019515750A (ja) | 2019-06-13 |
EP3451951A4 (fr) | 2019-12-25 |
KR20190098041A (ko) | 2019-08-21 |
BR112018072717A2 (pt) | 2019-02-19 |
JP2023027177A (ja) | 2023-03-01 |
SG11201809824VA (en) | 2018-12-28 |
CN110312482A (zh) | 2019-10-08 |
KR102448313B1 (ko) | 2022-09-28 |
AU2017261273A1 (en) | 2018-12-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US10335190B2 (en) | Pixel array medical systems, devices and methods | |
US10736653B2 (en) | Pixel array medical systems, devices and methods | |
US11871959B2 (en) | Pixel array medical systems, devices and methods | |
US11839402B2 (en) | Pixel array medical systems, devices and methods | |
US11612410B2 (en) | Pixel array medical systems, devices and methods | |
CA3023223A1 (fr) | Systemes, dispositifs et procedes medicaux de reseaux de pixels | |
AU2017218014B2 (en) | Pixel array medical systems, devices and methods | |
US11278309B2 (en) | Pixel array medical systems, devices and methods | |
CA3053243C (fr) | Systemes, dispositifs et procedes medicaux de reseaux de pixels | |
US11000310B2 (en) | Pixel array medical systems, devices and methods | |
US11311309B2 (en) | Pixel array medical systems, devices and methods | |
US11564706B2 (en) | Pixel array medical systems, devices and methods | |
US11730511B2 (en) | Pixel array medical systems, devices and methods | |
US20240197358A1 (en) | Pixel Array Medical Systems, Devices and Methods |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request |
Effective date: 20220802 |
|
EEER | Examination request |
Effective date: 20220802 |
|
EEER | Examination request |
Effective date: 20220802 |
|
EEER | Examination request |
Effective date: 20220802 |
|
EEER | Examination request |
Effective date: 20220802 |
|
EEER | Examination request |
Effective date: 20220802 |