CA3020520C - Table top image calibration phantom - Google Patents

Abstract

A device for measuring image quality properties of an image acquisition device while the subject or object is being scanned contains an embedded grid pattern to measure spatial distortion along the length of the image acquisition table. The device also contains reference materials, which may run along the length of the device, for measuring fundamental imaging properties such as signal strength, noise, and resolution. Automated software can detect the device within an acquisition, measure its properties, and provide data and reports on the quality of the image acquisition.

Description

TABLE TOP IMAGE CALIBRATION PHANTOM BACKGROUND Field of the Invention 5 The present invention relates to the calibration of imaging systems and, in one aspect, more particularly to a low form factor calibration phantom affixed to the table of an image acquisition scanner that provides calibrated reference geometry in the form of a regularly spaced grid line pattern and reference material samples for image calibration.

Description of the Related Art 10 Radiological quality assurance phantoms have been developed that evaluate the performance of a scanner with and without a patient or object of study present in the scanner.

Calibration phantoms that are designed to be used without an object of study in the scanner cannot directly verify the image quality of actual study scans. They are used to assert that the scanner was operating in a normal range of image quality performance at some time point 15 before the scan took place. In the case of Computed Tomography scanners, calibration with these phantoms is typically performed on a daily basis.

In recent years, phantoms have been developed that are designed to be scanned with the patient that result in scanner reference materials appearing within a patients' scan images. These phantoms have provided reference material samples for Hounsfield Unit (HU) 20 bias correction within quantitative imaging applications where unbiased and precise measurements of x-ray attenuation density is critical. This combined table phantom and measurement software has been implemented for bone density measurements for osteoporosis measurement and monitoring.

More recently table top phantoms have been proposed to capture fundamental 25 properties of an acquisition including resolution, noise, sampling rate, and x-ray attenuation measurement performance for a range of materials. Small calibrated spheres and other objects can be embedded in a calibration phantom that sits on the scanner table and automated software can be designed to measure these image acquisition properties. 30 BRIEF SUMMARY OF THE DISCLOSURE This summary is provided to introduce, in a simplified form, a selection of concepts that are further described below in the Detailed Description. This summary is not intended to identify key features of the claimed subject matter, nor is it intended to be used as an aid in determining the scope of the claimed subject matter. 1 Date Rec;ue/Date Received 2022-03-08 84742123 In one embodiment of the present invention a locally thin table top calibration device is affixed to a CT scanner table and provides information on spatial warping and imaging signal properties during patient CT scans.

In another embodiment of the present invention the locally thin table top calibration 5 device is scanned with a patient and an automated software system detects the device, measures the scan properties, and produces data and report on the quality of the image acquired.

According to one aspect of the present invention, there is provided a device for measuring image quality properties of an image acquisition device while an object or patient 10 is being scanned, comprising: a locally thin layered substrate adapted to match the outer shape of a scanner's table; wherein the layered substrate has a regular grid pattern adapted to indicate position and distortion along the surface of the scanner's table; and at least one material reference object is embedded within the air spaces of the grid pattern for measuring resolution, noise, and signal response properties. 15 According to another aspect of the present invention, there is provided a method for measuring image quality properties of an image acquisition device while an object or patient is being scanned, comprising: forming a locally thin layered substrate with a regular grid pattern having a plurality of air spaces, the substrate adapted to indicate position and distortion along the surface of a scanner's table; and matching the locally thin layered 20 substrate to the outer shape of the scanner's table; embedding at least one material reference object within the air spaces of the grid pattern; and measuring resolution, noise, and signal response properties.

According to another aspect of the present invention, there is provided a phantom device for measuring image quality properties of an image acquisition device while an object 25 or patient is being scanned, comprising: a layered substrate adapted to match and be affixed to a curved scanner table top; wherein the layered substrate has a grid pattern adapted to indicate position and distortion along the surface of the curved scanner table top; wherein the layered substrate includes air pockets; and at least one scanner-aligned material reference object embedded within air pockets of the grid pattern to provide a reference for 30 measuring resolution, noise, and signal response properties.

According to another aspect of the present invention, there is provided a method for measuring image quality properties of an image acquisition device while an object or patient is being scanned, comprising: forming a layered substrate with a regular grid pattern having a plurality of air pockets, the substrate adapted to indicate position and distortion along a 2 Date Re9ue/Date Received 2023-11-03 84742123 curved surface of; matching and affixing the layered substrate to the curved scanner table top; embedding at least one scanner-aligned material reference object within the air pockets of the grid pattern; and measuring resolution, noise, and signal response properties.

According to another aspect of the present invention, there is provided an automated 5 phantom analysis system comprising: a phantom device for measuring image quality properties of an image acquisition device while an object or patient is being scanned, the phantom device including a layered substrate adapted to match and be affixed to a curved scanner table top, wherein the layered substrate has a grid pattern adapted to indicate position and distortion along the surface of the curved scanner table top, wherein the layered 10 substrate includes air pockets, and at least one scanner-aligned material reference object embedded within air pockets of the grid pattern to provide a reference for measuring resolution, noise, and signal response properties.

BRIEF DESCRIPTION OF THE DRAWINGS 15 While the novel features of the invention are set forth with particularity in the appended claims, the invention, both as to organization and content, will be better understood and appreciated, along with other objects and features thereof, from the following detailed description taken in conjunction with the drawings, in which: FIG. 1 schematically shows an example of a locally thin, layered, curved image 20 quality calibration device affixed to an acquisition device table FIG. 2 schematically shows an axial cross section of an object or subject on top of a curved image quality calibration device which is all on top of an image acquisition device table (as shown in FIG. 1).

FIG. 3 shows an example of a plastic sheet having a regular pattern of diagonal lines 25 oriented along a first oblique angle. 2a Date Re9ue/Date Received 2023-11-03 FIG. 4 schematically shows an example of a curved image quality calibration device with a simulated diamond pattern.

FIG. 4A schematically illustrates formation of a simulated diamond pattern by overlapping diagonally patterned sheets at different orientations. 5 FIG. 5 shows a CT scan of reference material objects on a curved image quality calibration device having a diamond pattern.

FIG. 6A schematically shows an example of a CT disk phantom comprising multiple precision made concentric rings of different density material.

FIG. 6B schematically shows a cross-section view of a CT disk. 10 FIG. 7 schematically shows an example of a CT disk phantom with a rotating radial pattern.

In the drawings, identical reference numbers identify similar elements or components. The sizes and relative positions of elements in the drawings are not necessarily drawn to scale. For example, the shapes of various elements and angles 15 are not drawn to scale, and some of these elements are arbitrarily enlarged and positioned to improve drawing legibility. Further, the particular shapes of the elements as drawn, are not intended to convey any information regarding the actual shape of the particular elements, and have been solely selected for ease of recognition in the drawings. 20 DETAILED DESCRIPTION The following disclosure describes a calibration device. Several features of methods and systems in accordance with example embodiments are set forth and described in the figures. It will be appreciated that methods and systems in accordance with other example embodiments can include additional procedures or 25 features different than those shown in the figures. Example embodiments are described herein with respect to measuring scanner properties. However, it will be understood that these examples are for the purpose of illustrating the principles, and that the invention is not so limited. Additionally, methods and systems in accordance with several example embodiments may not include all of the features shown in the 30 figures.

Unless the context requires otherwise, throughout the specification and claims which follow, the word "comprise" and variations thereof, such as, "comprises" and 3 "comprising" are to be construed in an open, inclusive sense that is as "including, but not limited to." Reference throughout this specification to "one example" or "an example embodiment," "one embodiment," "an embodiment" or combinations and/or 5 variations of these terms means that a particular feature, structure or characteristic described in connection with the embodiment is included in at least one embodiment of the present disclosure. Thus, the appearances of the phrases "in one embodiment" or "in an embodiment" in various places throughout this specification are not necessarily all referring to the same embodiment. Furthermore, the particular 10 features, structures, or characteristics may be combined in any suitable manner in one or more embodiments.

A limitation of all table top calibration phantom approaches thus far developed is that they do not capture many sources of bias and variation present in modern day medical, security, and industrial scanners, including CT scanners. As a result of this, 15 the ability to measure the performance of a specific scan acquisition is compromised.

For example, spatially varying image warping can occur in some CT scanners and acquisition protocols which can significantly degrade the utility of the scan for performing measurements such as volumetric size change measurements. In addition, noise and x-ray attenuation properties can be spatially varying, particularly 20 in CT systems where imaging properties tend to vary radially. Measuring local spatial resolution and x-ray attenuation performance with one set of reference materials near the center of a scanner, as is done with most calibration phantoms, will not fully capture many types of image quality and calibration variation.

Precision manufactured reference objects such as one or more spheres can 25 be used to measure fundamental image properties such as image resolution, x-ray attenuation properties, and noise levels. However, placing precision manufactured and calibrated reference objects at many radial positions within a table top phantom device will result in a prohibitively high cost device. More importantly, if too much high density material is used or these phantom reference objects are placed in linear 30 geometric configurations, the resulting scans can contain significant artifacts.

Creating artifacts in the images to be measured is a major problem for phantoms that are scanned simultaneously with patients. The materials and geometry must be designed such that artifacts are minimized. 4 The present invention uses scanner-aligned cylinders of reference materials that when analyzed with software algorithms result in fundamental image acquisition properties such as the 3D PSF (point spread function), x-ray attenuation, noise and other signal properties of the image. The use of a cylinder or disk shaped geometry, 5 as shown in FIG. 2, exploits the radial symmetry of a CT scan reconstruction.

Specifically, since the X & Y resolution of a CT scanner are typically identical and Z resolution is different, it is sufficient to measure just the X & Z resolution to estimate the 3D PSF.

Using a cylinder or disk shaped reference object is also much easier and less 10 costly to manufacture than embedding spherical objects into a calibration phantom, particularly when material homogeneity and precise dimensional tolerances are needed. In fact, most precision manufactured plastic spheres (e.g. Teflon® and Delrin® plastic spheres) are made from extruded rod to arrive at better material homogeneity properties (e.g. without air voids). Disk shaped reference objects also 15 have the potential to utilize the least amount of phantom material, leading to calibration devices that result in lower amounts of phantom generated image artifacts. This is particularly important when deployed for clinical studies involving precise measurements with little tolerance for increased image noise and other artifacts, such as is the case in CT perfusion studies. 20 Another major source of CT image variation that can impact quantitative measurements is spatial warping, which is particularly associated with helical CT scanning modes. To measure spatial warping, it is highly advantageous to construct a calibration phantom that contains a regular geometric pattern of material and analyze the pattern in the acquired image for spatial deformations. This technique 25 has been successfully developed and deployed using a 3D grid of spheres in the MRI setting. However, as mentioned earlier, a regular grid on a plane of material can cause large CT artifacts and shadows that will obscure and deform the needed reference geometry.

Referring now to FIG. 1, a low form factor diamond shaped grid 16 is placed 30 inside a curved table top phantom 12, which sits on top of a curved table 1 0 with the same curvature, thereby avoiding opportunities for the phantom grid geometry to form attenuation artifacts and streaks in the resulting images. A diamond pattern 15 is advantageous since there is little opportunity for material to align along the path of x-rays as they travel from an x-ray source to a detector, typically in a fan or cone geometry. Reference object materials 14 are placed at the center and at one or both sides of the calibration device 12. The reference object materials 14 are oriented with the coordinate system of the image acquisition system and are shown here to run down the center of the calibration device 12 as well as down both sides. Each 5 reference object contains an internal material to be measured and a background homogeneous material surrounding the internal material.

This type of table top phantom will need to be affixed to the CT table to maintain high levels of alignment with the scanners coordinate system and acquisition geometry. It is particularly important that the device moves identical to the 10 scanner table during the scan acquisition. Plastic fixtures including the use of snaps, adhesives, and/or a hook and loop fasteners, such as Velcro® fasteners for example, can be added to the CT table to ensure that the CT table top phantom remains in the desired position.

In one embodiment a curved table top phantom consists of high density 15 polystyrene and air to create a high contrast, but low CT density, it has a diamond shaped grid that runs along a substantial length of the CT table. The curved 2D plastic and air grid within such a phantom has diamond shaped air pockets, some of which can be filled with scanner coordinate system aligned and homogeneous reference materials using cylindrical shapes. At a minimum, a set of reference 20 material cylinders running down the center of the table top phantom and along an outer table edge would allow attenuation analysis to look for and characterize radial variation effects. The reference disks 14 should be constructed with a homogeneous internal reference material and a uniform outer material such as urethane. The uniform outer material is used both to protect the integrity of the reference sample 25 and to provide a homogeneous material with which to observe edge effects or partial volume artifact for resolution and other measurements. The size of these disks should be constructed such that they are sufficiently far enough away from the plastic grid pattern so as not to impact the reconstructed densities of the grid. If the reference material is to be used for measuring resolution, as is typically done with 30 Teflon® or other high density materials, the amount of outer material encasing the reference sample must be sufficient to obtain a full transition from reference material signal intensities to outer material intensities. For current CT scanners and protocols this is around 6mm of outer material. 6 Referring now to FIG. 3, an example of a plastic sheet 30 having a pattern of diagonal strips 33 oriented along a first oblique angle is shown. The table top phantom may advantageously consist of two such plastic sheets 30A, 30B (as best shown in FIG. 4A) placed one on top of the other with the stripping of one facing and 5 contacting the stripping of the other to form a diamond pattern. In one example the sheets may be made of 1.5mm thick plastic (e.g. high density polystyrene) each with regularly spaced diagonal strips that are 4mm wide and 1.5mm thick and with a 50mm spacing interval. The diagonal strips may be angled at about 45 degrees.

Referring now to FIG. 4, an example of a curved image quality calibration 10 device with a simulated diamond pattern is schematically shown. The diagonal strips 33 have been augmented with a penciled in set of perpendicular lines 33A to illustrate the final diagonal pattern that results when the two sheets are affixed together. In an actualized embodiment, the diamond pattern 15 will result with diamond shaped air voids 40 available for placing material reference disks. Affixing 15 the two sheets of curved material with regularly spaced strips has the potential to result in a low cost manufacturing process.

Referring now to FIG. 4A formation of a simulated diamond pattern by overlapping diagonally patterned sheets at different orientations is schematically illustrated. A first plastic sheet 30A is overlapped with a second plastic sheet 30B. 20 Each of the plastic sheets include diagonal strips 33 oriented along a preselected axis. The first and second plastic sheets may be identical, for example, and the sheets are rotated 90 degrees with respect to one another such that the diagonal strips 33 form a diamond pattern 15 when the sheets are rotated and overlap with each other. Here, the overlapping area is 43 with air voids 40. 25 However, in another preferred embodiment the table top phantom containing a diamond grid pattern is constructed as one contiguous grid of plastic material with fittings for disk or sphere shaped reference materials, which can be easier and less costly to obtain and work with. In another preferred embodiment the table top calibration device contains port holes for access to the reference object materials, 30 which can be removed or replaced.

Another optional component of the system is automated analysis software.

Automated analysis software can be constructed that detects and measures the table top phantom producing a report that describes the fundamental characteristics 7 of an individual CT acquisition. The automated software can further alert the institution performing the scan of any issues identified when the scan was analyzed.

Referring now to FIG. 5, a 3D CT scan of reference material objects on a diamond pattern calibration device is shown. A plurality of different reference objects 5 14 have been scanned on a curved, diamond pattern calibration device 12 as disclosed herein. Once having the scan, the properties of the imaging device can be precisely measured since the dimensions of the reference objects 14 are known.

Referring now to FIG. 6A, an example of a CT disk phantom comprising multiple precision made concentric rings of different density material is schematically 10 shown. A CT disk phantom 600 includes an inner cylinder 60 of air material surrounded by a second cylinder 62 of a high density material, as for example, Teflon® brand Polytetrafluoroethylene (PTFE) or the like. The inner cylinder 60 and second cylinder 62 are concentrically surrounded by a third cylinder 64 of another material, as for example, Delrin® brand Polyoxymethylene (POM), or the like. An 15 optional fourth cylinder 66 concentrically surrounds the inner cylinder 60, the second cylinder 62 and the third cylinder 64. The fourth cylinder may be made of low-density polyethylene (LOPE) plastic or the like, for example. The entire CT disk may be encased in a urethane material 68 except for the inner hole/air material 60. That is, the second through fourth cylinders may be encased in urethane, where the 20 urethane case includes openings on the top and bottom of the CT disk so that the inner cylinder 60 and the inner surface of the second cylinder surrounding the inner cylinder are not covered. The resulting CT disk is an extremely compact shape that has advantages in construction cost and manufacture due to the concentric disk shapes. Due to the compactness only a very small amount of material is needed to 25 make the CT disk. The compact disk keeps artifacts low, particularly when the disk or disks are placed within the aforedescribed table phantom. The distinct concentric disk shapes and materials can easily be automatically detected and measured.

Further the ordering of the materials can be varied and switched, or all of the discs and the central air hole can be encased in urethane. 30 Referring now briefly to FIG. 68, a cross-section view of a CT disk is schematically shown. Here the ordering of the materials comprising the inner cylinder 60, second cylinder 62, third cylinder 64 and fourth cylinder 66 is further illustrated. The urethane casing 68 surrounds the second through fourth cylinders leaving the inner cylinder 60 open and uncovered through the center of the disk. 8 Referring now to FIG. 7, an example of a CT disk phantom with a rotating radial pattern is schematically shown. A radial pattern 72 is affixedly centered on the top face 71 of a CT disk 600. A clock 70 is coupled to rotate the top face. The clock may be, for example, a precision wound plastic clock that can uniformly rotate the 5 top face for a few minutes. A resulting rotating pattern can then be used to measure the temporal resolution of a selected scanner. Note that none of the components should contain any metal or very high density materials since such materials would create artifacts in CT. In operation, the clock can be non-metal spring wound (e.g. fiberglass, plastic, or other materials) and cause the CT disk to spin while operating 10 the scanner to obtain scanning images.

An entire disc or group of discs can be CT scanned independently or embedded within a CT table phantom and scanned. The resulting scanned images can then be analyzed to obtain estimates of resolution, x-ray attenuation properties, noise, spatial warping, edge enhancement, and other image quality characteristics.

The invention has been described herein in considerable detail in order to comply with the Patent Statutes and to provide those skilled in the art with the information needed to apply the novel principles of the present invention, and to construct and use such exemplary and specialized components as are required. 20 However, it is to be understood that the invention may be carried out by different equipment, and devices, and that various modifications, both as to the equipment details and operating procedures, may be accomplished without departing from the true spirit and scope of the present invention. 9

Claims (3)

1. CLAIMS: 1. A phantom device for measuring image quality properties of an image acquisition device while an object or patient is being scanned, comprising: a layered substrate adapted to match and be affixed to a curved scanner table top; 5 wherein the layered substrate has a grid pattern adapted to indicate position and distortion along the surface of the curved scanner table top; wherein the layered substrate includes air pockets of the grid pattern; and at least one scanner-aligned material reference object embedded within the air pockets of the grid pattern to provide a reference for measuring resolution, noise, and 1 O signal response properties.
2. 2. The phantom device of claim 1 wherein the grid pattern comprises a diamond shaped grid pattern.
3. 3. The phantom device of claim 2 where the grid pattern comprises at least two overlapping sheets of material with opposing parallel lines that are regularly spaced. 15 4. The phantom device of claim 1 wherein the at least one scanner-aligned material reference object is placed in the air pockets of the grid pattern along the length of the phantom device and running down the length of the curved scanner table top at center and along at least one side of the layered substrate. 5. The phantom device of claim 1 wherein the at least one scanner-aligned material 20 reference object is spherical or cylindrical in shape and oriented with a scanner coordinate system. 6. The phantom device of claim 5 wherein the at least one scanner-aligned material reference object comprises an internal material and a different background material. 7. The phantom device of claim 1 wherein the phantom device further comprises fastening 25 elements that allow it to be physically affixed to the curved scanner table top. Date Re9ue/Date Received 2024-03-28 84742123 8. The phantom device of claim 1 wherein the phantom device further comprises a plurality of ports located to access the at least one scanner-aligned material reference object. 9. The phantom device of claim 1 wherein materials of the phantom device are adapted for measuring image quality of CT, XR, PET/CT, NM, MRI, or Ultrasound scans. 5 10. The phantom device of claim 1 wherein materials of the phantom device are adapted for CT multi-energy scanning, including iodine and calcium. 11. The phantom device of claim 1 wherein the layered substrate is made of plastic. 12. A method for measuring image quality properties of an image acquisition device while an object or patient is being scanned, comprising: 10 forming a layered substrate with a regular grid pattern having a plurality of air pockets, the substrate adapted to indicate position and distortion along a curved surface of; matching and affixing the layered substrate to a curved scanner table top; embedding at least one scanner-aligned material reference object within the air pockets of the grid pattern; and 15 measuring resolution, noise, and signal response properties. 13. The method of claim 12 wherein forming the layered substrate with the regular grid pattern comprises a forming a diamond shaped grid pattern. 14. The method of claim 12 wherein forming the layered substrate comprises juxtaposing two sheets of material with parallel lines that are regularly spaced and form a diamond pattern. 20 15. The method of claim 12 further comprising placing the at least one scanner-aligned material reference object in the air pockets of the grid pattern along the length of a phantom device and running down the length of the curved scanner table top at center and along at least one side of the layered substrate. 11 Date Re9ue/Date Received 2024-03-28 84742123 16. The method of claim 12 wherein measuring the resolution, noise, and signal response properties comprises measuring image quality of CT, XR, PET/CT, NM, MRI, or Ultrasound scans. 17. The method of claim 12 wherein the layered substrate is made of plastic. 5 18. An automated phantom analysis system comprising: a phantom device for measuring image quality properties of an image acquisition device while an object or patient is being scanned, the phantom device including a layered substrate adapted to match and be affixed to a curved scanner table top, wherein the layered substrate has a grid pattern adapted to indicate position and distortion along the surface of 10 the curved scanner table top, wherein the layered substrate includes air pockets of the grid pattern, and at least one scanner-aligned material reference object embedded within the air pockets of the grid pattern to provide a reference for measuring resolution, noise, and signal response properties. 19. The automated phantom analysis system of claim 18 wherein the layered substrate is 15 made of plastic.