CA3015839A1 - Connexin (cx)43 hemichannel-binding antibodies and uses thereof - Google Patents
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Neurology (AREA)
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- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662300492P | 2016-02-26 | 2016-02-26 | |
| US62/300,492 | 2016-02-26 | ||
| PCT/US2017/019605 WO2017147561A1 (en) | 2016-02-26 | 2017-02-27 | CONNEXIN (Cx) 43 HEMICHANNEL-BINDING ANTIBODIES AND USES THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3015839A1 true CA3015839A1 (en) | 2017-08-31 |
Family
ID=59685694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3015839A Pending CA3015839A1 (en) | 2016-02-26 | 2017-02-27 | Connexin (cx)43 hemichannel-binding antibodies and uses thereof |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10889637B2 (enExample) |
| EP (1) | EP3419998A4 (enExample) |
| JP (1) | JP7098527B2 (enExample) |
| CN (2) | CN116672445A (enExample) |
| AU (2) | AU2017224122B2 (enExample) |
| CA (1) | CA3015839A1 (enExample) |
| WO (1) | WO2017147561A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11912762B2 (en) | 2013-08-21 | 2024-02-27 | Board Of Regents Of The University Of Texas System | Method of treating osteoarthritis by administering an anti-connexin 43 antibody |
| US11912758B2 (en) | 2016-02-26 | 2024-02-27 | The Board Of Regents Of The University Of Texas System | Methods of treating metastasis, including inhibiting bone cancer metastasis, by administering an antibody which binds connexin 43 (Cx43) hemichannel |
| US12503500B2 (en) | 2024-02-09 | 2025-12-23 | Board Of Regents, The University Of Texas System | Connexin 43 (Cx43) hemichannel-binding antibodies |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2710220A1 (es) * | 2017-10-19 | 2019-04-23 | Fund Profesor Novoa Santos | Compuestos anti-conexina para su uso en la prevención y/o el tratamiento de enfermedades degenerativas de las articulaciones |
| AU2019249427A1 (en) * | 2018-04-02 | 2020-10-29 | Alamab Therapeutics, Inc. | Connexin 43 antibodies and use thereof |
| WO2019222800A1 (en) * | 2018-05-21 | 2019-11-28 | Hudson Institute of Medical Research | Methods for the treatment or prevention of autoimmune or autoinflammatory diseases |
| US12187794B2 (en) * | 2019-02-04 | 2025-01-07 | Alamab Therapeutics, Inc. | Connexin 43 antibodies and use thereof |
| JP7710374B2 (ja) * | 2019-02-28 | 2025-07-18 | ボード オブ リージェンツ ザ ユニヴァーシティ オブ テキサス システム | 骨肉腫を治療するための組成物及び使用方法 |
| AU2020358101A1 (en) | 2019-10-02 | 2022-04-28 | Alamab Therapeutics, Inc. | Anto-connexin antibody formulations |
| WO2022026914A1 (en) * | 2020-07-31 | 2022-02-03 | Alamab Therapeutics, Inc. | Anti-connexin antibody formulations |
| EP3981421A1 (en) * | 2020-10-06 | 2022-04-13 | Fundación Profesor Novoa Santos | Connexin 43 for use in the treatment of a cancer type characterized by the activation of a mitogen-activated protein kinase |
| CN117377686A (zh) * | 2021-01-13 | 2024-01-09 | 德克萨斯大学体系董事会 | 用于治疗骨关节炎、类风湿性关节炎以及关节和肌腱病症的组合物和方法 |
| WO2023212727A1 (en) * | 2022-04-29 | 2023-11-02 | Board Of Regents, The University Of Texas System | Compositions and methods for treating eye diseases |
| JP2025515029A (ja) * | 2022-05-04 | 2025-05-13 | ブイエスティー バイオ コーポレーション | 血管透過性の選択的調節のための組成物及び方法 |
| WO2024145461A2 (en) * | 2022-12-30 | 2024-07-04 | Board Of Regents, The University Of Texas System | Compositions for treating osteoporosis and bone loss and methods of use thereof |
| WO2024206157A1 (en) * | 2023-03-24 | 2024-10-03 | Board Of Regents, The University Of Texas System | Compositions and methods for treating obesity and reducing fat accumulation |
| WO2025199516A1 (en) * | 2024-03-22 | 2025-09-25 | Board Of Regents, The University Of Texas System | Compositions and methods for preserving or increasing lean muscle mass |
| CN118791620B (zh) * | 2024-07-02 | 2025-04-04 | 北京市华信行生物科技有限公司 | 抗糖原磷酸化酶gpbb单克隆抗体及其应用 |
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| WO2013163423A1 (en) | 2012-04-25 | 2013-10-31 | Musc Foundation For Research Development | Compositions and methods for wound healing and tissue repair |
| EP3036005A4 (en) | 2013-08-21 | 2017-04-26 | The Board Of Regents Of The University Of Texas System | Compositions and methods for targeting connexin hemichannels |
| WO2017147561A1 (en) | 2016-02-26 | 2017-08-31 | The Board Of Regents Of The University Of Texas System | CONNEXIN (Cx) 43 HEMICHANNEL-BINDING ANTIBODIES AND USES THEREOF |
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2017
- 2017-02-27 WO PCT/US2017/019605 patent/WO2017147561A1/en not_active Ceased
- 2017-02-27 JP JP2018545296A patent/JP7098527B2/ja active Active
- 2017-02-27 CN CN202210879114.2A patent/CN116672445A/zh active Pending
- 2017-02-27 CA CA3015839A patent/CA3015839A1/en active Pending
- 2017-02-27 EP EP17757405.0A patent/EP3419998A4/en active Pending
- 2017-02-27 CN CN201780025896.0A patent/CN109071642B/zh active Active
- 2017-02-27 US US16/078,990 patent/US10889637B2/en active Active
- 2017-02-27 AU AU2017224122A patent/AU2017224122B2/en active Active
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2021
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2024
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11912762B2 (en) | 2013-08-21 | 2024-02-27 | Board Of Regents Of The University Of Texas System | Method of treating osteoarthritis by administering an anti-connexin 43 antibody |
| US12162937B2 (en) | 2013-08-21 | 2024-12-10 | Board Of Regents Of The University Of Texas System | Methods of treating an inflammatory disorder by administering an antibody which binds to a connexin CX43 hemichannel |
| US11912758B2 (en) | 2016-02-26 | 2024-02-27 | The Board Of Regents Of The University Of Texas System | Methods of treating metastasis, including inhibiting bone cancer metastasis, by administering an antibody which binds connexin 43 (Cx43) hemichannel |
| US12503500B2 (en) | 2024-02-09 | 2025-12-23 | Board Of Regents, The University Of Texas System | Connexin 43 (Cx43) hemichannel-binding antibodies |
Also Published As
| Publication number | Publication date |
|---|---|
| US20190359696A1 (en) | 2019-11-28 |
| JP7098527B2 (ja) | 2022-07-11 |
| US20240254212A1 (en) | 2024-08-01 |
| AU2017224122A1 (en) | 2018-09-20 |
| EP3419998A4 (en) | 2019-09-25 |
| CN109071642B (zh) | 2022-08-09 |
| WO2017147561A1 (en) | 2017-08-31 |
| AU2017224122B2 (en) | 2024-04-11 |
| AU2024204761A1 (en) | 2024-08-01 |
| EP3419998A1 (en) | 2019-01-02 |
| US10889637B2 (en) | 2021-01-12 |
| US11912758B2 (en) | 2024-02-27 |
| US20210253680A1 (en) | 2021-08-19 |
| CN109071642A (zh) | 2018-12-21 |
| JP2019509283A (ja) | 2019-04-04 |
| CN116672445A (zh) | 2023-09-01 |
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