CA3012009A1 - Procedes d'activation de la proliferation de cellules regulatrices t - Google Patents
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- CA3012009A1 CA3012009A1 CA3012009A CA3012009A CA3012009A1 CA 3012009 A1 CA3012009 A1 CA 3012009A1 CA 3012009 A CA3012009 A CA 3012009A CA 3012009 A CA3012009 A CA 3012009A CA 3012009 A1 CA3012009 A1 CA 3012009A1
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- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
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- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/46433—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/46434—Antigens related to induction of tolerance to non-self
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
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Abstract
La présente invention concerne d'une manière générale un procédé d'activation de la prolifération de cellules régulatrices T (Treg) in vitro, comprenant la mise en contact des Treg avec des cellules (I), ou du milieu conditionné à partir des cellules, en présence d'un ou plusieurs agents de stimulation Treg. Le ou les agents de stimulation Treg sont présents en une quantité et pendant une durée efficaces pour stimuler la prolifération des Treg. Les cellules (I) sont présentes en une quantité et pendant une durée efficaces pour activer la prolifération des Treg. Les cellules (I) sont des cellules souches non embryonnaires, non germinales, caractérisées par une ou plusieurs des caractéristiques suivantes : réplication prolongée en culture et marqueurs d'expression de réplication prolongée, marqueurs d'expression de pluripotentialité, et présentent un potentiel de différenciation large, ne sont ni tumorigènes ni transformées, et présentent un caryotype normal. L'invention concerne également des procédés de modulation immunitaire utilisant les Treg ayant proliféré, des banques de cellules, des procédés de découverte de médicament, des populations, et des compositions de Treg ayant proliféré.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2015/054941 WO2017062035A1 (fr) | 2015-10-09 | 2015-10-09 | Procédés d'activation de la prolifération de cellules régulatrices t |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3012009A1 true CA3012009A1 (fr) | 2017-04-13 |
Family
ID=58488261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3012009A Abandoned CA3012009A1 (fr) | 2015-10-09 | 2015-10-09 | Procedes d'activation de la proliferation de cellules regulatrices t |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US20190358258A1 (fr) |
| CA (1) | CA3012009A1 (fr) |
| WO (1) | WO2017062035A1 (fr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2568991T6 (en) | 2010-05-12 | 2019-03-18 | Abt Holding Co | MODULATION OF SPLENOCYTES IN CELL THERAPY |
| HUE052516T2 (hu) | 2013-04-12 | 2021-05-28 | Houston Methodist Hospital | Szervek javítása transzplantációhoz |
| AU2016387339B2 (en) | 2016-01-21 | 2022-11-17 | Abt Holding Company | Stem cells for wound healing |
| WO2018106885A1 (fr) | 2016-12-07 | 2018-06-14 | East Carolina University | Compositions et méthodes de culture et/ou de croissance in vitro de lymphocytes t régulateurs |
| CA3051469A1 (fr) * | 2017-01-27 | 2018-08-02 | Abraham J And Phyllis Katz Cord Blood Foundation | Lymphocytes t derives de sang de cordon ombilical |
| CN113365650A (zh) | 2018-11-16 | 2021-09-07 | 新免疫技术有限公司 | 用il-7蛋白和免疫检查点抑制剂的组合治疗肿瘤的方法 |
| AU2020210635A1 (en) | 2019-01-22 | 2021-08-19 | Bristol Myers Squibb Company | Antibodies against IL-7R alpha subunit and uses thereof |
| US20220184121A1 (en) * | 2019-03-18 | 2022-06-16 | The Regents Of The University Of California | Augmentation of t-cell activation by oscillatory forces and engineered antigen-presenting cells |
| CN114945409A (zh) | 2020-01-13 | 2022-08-26 | 新免疫技术有限公司 | 用il-7蛋白和双特异性抗体的组合治疗肿瘤的方法 |
| EP4100045A1 (fr) | 2020-02-05 | 2022-12-14 | Washington University | Procédé de traitement d'une tumeur solide avec une combinaison d'une protéine d'il-7 et de cellules immunitaires porteuses de car |
| EP3895710A1 (fr) | 2020-04-15 | 2021-10-20 | DSM IP Assets B.V. | Aliment et/ou compositions alimentaires pour gérer l'homéostasie immunitaire |
| WO2023130081A1 (fr) | 2021-12-30 | 2023-07-06 | Neoimmunetech, Inc. | Procédé de traitement d'une tumeur avec une combinaison d'une protéine il-7 et d'un antagoniste du vegf |
| WO2024102722A1 (fr) | 2022-11-07 | 2024-05-16 | Neoimmunetech, Inc. | Procédés de traitement d'une tumeur avec un promoteur mgmt non méthylé |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030049696A1 (en) * | 2001-06-07 | 2003-03-13 | Norment Anne M. | Regulatory T cells and uses thereof |
| US7651855B2 (en) * | 2003-04-17 | 2010-01-26 | The Trustees Of The University Of Pennsylvania | Regulatory T cells and their use in immunotherapy and suppression of autoimmune responses |
| US8241621B2 (en) * | 2006-12-18 | 2012-08-14 | Medistem Laboratories | Stem cell mediated treg activation/expansion for therapeutic immune modulation |
| US20090053182A1 (en) * | 2007-05-25 | 2009-02-26 | Medistem Laboratories, Inc. | Endometrial stem cells and methods of making and using same |
| WO2010129770A1 (fr) * | 2009-05-07 | 2010-11-11 | The University Of Utah Research Foundation | Procédés d'expansion de lymphocytes t régulateurs humains et leurs utilisations |
-
2015
- 2015-10-09 US US15/767,085 patent/US20190358258A1/en not_active Abandoned
- 2015-10-09 WO PCT/US2015/054941 patent/WO2017062035A1/fr active Application Filing
- 2015-10-09 CA CA3012009A patent/CA3012009A1/fr not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017062035A1 (fr) | 2017-04-13 |
| US20190358258A1 (en) | 2019-11-28 |
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