CA3009520A1 - Caracterisation sans marqueur de particules en suspension dans un fluide - Google Patents
Caracterisation sans marqueur de particules en suspension dans un fluide Download PDFInfo
- Publication number
- CA3009520A1 CA3009520A1 CA3009520A CA3009520A CA3009520A1 CA 3009520 A1 CA3009520 A1 CA 3009520A1 CA 3009520 A CA3009520 A CA 3009520A CA 3009520 A CA3009520 A CA 3009520A CA 3009520 A1 CA3009520 A1 CA 3009520A1
- Authority
- CA
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- Prior art keywords
- particle
- detection
- particles
- modulation
- detection element
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects thereof, e.g. conductivity or capacity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
- G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
-
- G01N2015/1027—
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Electro-optical investigation, e.g. flow cytometers
- G01N2015/1486—Counting the particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
- G01N27/74—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
- G01N27/745—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids for detecting magnetic beads used in biochemical assays
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Dispersion Chemistry (AREA)
- Hematology (AREA)
- Sustainable Development (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Nanotechnology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Abstract
L'invention concerne des procédés et des systèmes qui caractérisent une propriété d'une particule en suspension dans un échantillon fluide sans utiliser de marqueur. Des éléments de détection sont fournis adjacents sur le plan fluidique en amont et en aval d'un élément de modulation. Un échantillon fluide contenant des particules s'écoule à travers un premier élément de détection et un premier paramètre de particule détecté pour chaque particule qui passe le premier élément de détection ou un premier paramètre de particule agrégée pour une pluralité de particules qui passent le premier élément de détection. Les particules s'écoulent du premier élément de détection vers un premier élément de modulation, le premier élément de modulation effectuant un changement d'une propriété des particules s'écoulant au-delà du premier élément de modulation. Un second élément de détection détecte ensuite à nouveau le paramètre de particule ou un second paramètre de particule agrégée pour une pluralité de particules qui passent le second élément de détection. La comparaison des premier et second paramètres de particule ou d'agrégat caractérise ainsi la propriété des particules.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662277736P | 2016-01-12 | 2016-01-12 | |
| US62/277,736 | 2016-01-12 | ||
| PCT/US2017/013155 WO2017123730A1 (fr) | 2016-01-12 | 2017-01-12 | Caractérisation sans marqueur de particules en suspension dans un fluide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3009520A1 true CA3009520A1 (fr) | 2017-07-20 |
Family
ID=59311552
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3009520A Abandoned CA3009520A1 (fr) | 2016-01-12 | 2017-01-12 | Caracterisation sans marqueur de particules en suspension dans un fluide |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20190011349A1 (fr) |
| EP (1) | EP3403066A4 (fr) |
| CN (1) | CN108700499A (fr) |
| CA (1) | CA3009520A1 (fr) |
| WO (1) | WO2017123730A1 (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015148981A1 (fr) | 2014-03-28 | 2015-10-01 | The Board Of Trustees Of The University Of Illinois | Détection d'analyte sans marqueur par des transistors à effet de champ |
| US11266984B2 (en) * | 2017-08-03 | 2022-03-08 | The Board Of Trustees Of The Leland Stanford Junior University | Massive microfluidics for multiplexed counting |
| US11732293B2 (en) | 2017-10-06 | 2023-08-22 | The Board Of Trustees Of The University Of Illinois | Biomarker detection from fluid samples |
| AU2020361681A1 (en) | 2019-10-10 | 2022-05-05 | 1859, Inc. | Methods and systems for microfluidic screening |
| US11845084B2 (en) | 2020-05-04 | 2023-12-19 | The Board Of Trustees Of The University Of Illinois | Microchip high density hanging drop three-dimension culture platform |
| CN112345624A (zh) * | 2020-10-27 | 2021-02-09 | 北京信息科技大学 | 一种基于巨磁阻效应的高灵敏度金属磨损颗粒检测传感器 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY146468A (en) * | 2006-03-15 | 2012-08-15 | Gen Hospital Corp | Devices and methods for detecting cells and other analytes |
| EP2259045A1 (fr) * | 2009-06-05 | 2010-12-08 | Koninklijke Philips Electronics N.V. | Procédé et dispositif d'impédance multi-fréquence pour la discrimination et le comptage de particules exprimant un marqueur spécifique |
| CN109946446A (zh) * | 2010-11-09 | 2019-06-28 | 综合医院公司 | 使用电差分计数器对颗粒计数 |
| US20140154703A1 (en) * | 2011-01-06 | 2014-06-05 | Alison Skelley | Circulating tumor cell capture on a microfluidic chip incorporating both affinity and size |
| JP2016527494A (ja) * | 2013-07-05 | 2016-09-08 | ユニバーシティ オブ ワシントン スルー イッツ センター フォー コマーシャライゼーション | マイクロ流体アッセイのための方法、組成物およびシステム |
| WO2017070602A1 (fr) * | 2015-10-22 | 2017-04-27 | Georgia Tech Research Corporation | Capteurs électroniques pour la détection multiplexée de particules sur des puces microfluidiques et leurs utilisations |
-
2017
- 2017-01-12 EP EP17738912.9A patent/EP3403066A4/fr not_active Withdrawn
- 2017-01-12 WO PCT/US2017/013155 patent/WO2017123730A1/fr active Application Filing
- 2017-01-12 CA CA3009520A patent/CA3009520A1/fr not_active Abandoned
- 2017-01-12 CN CN201780016085.4A patent/CN108700499A/zh active Pending
- 2017-01-12 US US16/068,945 patent/US20190011349A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN108700499A (zh) | 2018-10-23 |
| WO2017123730A1 (fr) | 2017-07-20 |
| EP3403066A1 (fr) | 2018-11-21 |
| EP3403066A4 (fr) | 2019-10-30 |
| US20190011349A1 (en) | 2019-01-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20210831 |
|
| FZDE | Discontinued |
Effective date: 20210831 |