CA3008892A1 - Covalent polymer-antigen conjugated particles - Google Patents

Covalent polymer-antigen conjugated particles Download PDF

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Publication number
CA3008892A1
CA3008892A1 CA3008892A CA3008892A CA3008892A1 CA 3008892 A1 CA3008892 A1 CA 3008892A1 CA 3008892 A CA3008892 A CA 3008892A CA 3008892 A CA3008892 A CA 3008892A CA 3008892 A1 CA3008892 A1 CA 3008892A1
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CA
Canada
Prior art keywords
particle
disease
antigen
particles
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3008892A
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English (en)
French (fr)
Inventor
Ryan Pearson
Daniel R. Getts
John PUISIS
James Herrmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cour Pharmaceuticals Development Co Inc
Original Assignee
Cour Pharmaceuticals Development Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cour Pharmaceuticals Development Co Inc filed Critical Cour Pharmaceuticals Development Co Inc
Publication of CA3008892A1 publication Critical patent/CA3008892A1/en
Pending legal-status Critical Current

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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
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    • A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/6943—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a pill, a tablet, a lozenge or a capsule
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    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61K9/5107—Excipients; Inactive ingredients
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    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Nanotechnology (AREA)
  • Hematology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
CA3008892A 2015-12-23 2016-12-22 Covalent polymer-antigen conjugated particles Pending CA3008892A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562387183P 2015-12-23 2015-12-23
US62/387,183 2015-12-23
US201662292098P 2016-02-05 2016-02-05
US62/292,098 2016-02-05
PCT/US2016/068423 WO2017112899A1 (en) 2015-12-23 2016-12-22 Covalent polymer-antigen conjugated particles

Publications (1)

Publication Number Publication Date
CA3008892A1 true CA3008892A1 (en) 2017-06-29

Family

ID=59091248

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3008892A Pending CA3008892A1 (en) 2015-12-23 2016-12-22 Covalent polymer-antigen conjugated particles

Country Status (8)

Country Link
US (2) US11510996B2 (enExample)
EP (1) EP3393514A4 (enExample)
JP (3) JP7194593B2 (enExample)
KR (1) KR102822161B1 (enExample)
AU (1) AU2016379413B2 (enExample)
CA (1) CA3008892A1 (enExample)
IL (1) IL260074B1 (enExample)
WO (1) WO2017112899A1 (enExample)

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AU2022257035A1 (en) 2021-04-16 2023-11-30 Cour Pharmaceuticals Development Company Inc. Method of tracking maintenance of immunological tolerance
JP2024540865A (ja) 2021-10-21 2024-11-06 クール ファーマシューティカルズ ディベロップメント カンパニー インコーポレイテッド 寛容化ナノ粒子による原発性胆汁性胆管炎（ｐｂｃ）の治療
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EP4561603A1 (en) 2022-07-29 2025-06-04 Repertoire Immune Medicines, Inc. T cell epitopes associated with type 1 diabetes
TW202430207A (zh) 2022-10-19 2024-08-01 美商庫爾製藥發展公司股份有限公司 以免疫耐受性(tolerizing)奈米粒子治療花生過敏
TW202444434A (zh) 2023-03-24 2024-11-16 美商庫爾製藥發展公司股份有限公司 用於重症肌無力治療之免疫修飾奈米粒子之處理
WO2024243410A1 (en) 2023-05-23 2024-11-28 Cour Pharmaceuticals Development Company Inc. Preparation of tolerizing nanoparticles for the treatment of primary biliary cholangitis
TW202500576A (zh) 2023-05-25 2025-01-01 美商庫爾製藥發展公司股份有限公司 以免疫耐受性(tolerizing)奈米粒子治療1型糖尿病(t1d)
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