CA3002965A1 - Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tightened gut mucosal barrier - Google Patents

Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tightened gut mucosal barrier Download PDF

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Publication number
CA3002965A1
CA3002965A1 CA3002965A CA3002965A CA3002965A1 CA 3002965 A1 CA3002965 A1 CA 3002965A1 CA 3002965 A CA3002965 A CA 3002965A CA 3002965 A CA3002965 A CA 3002965A CA 3002965 A1 CA3002965 A1 CA 3002965A1
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Canada
Prior art keywords
gene
bacterium
butyrate
promoter
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3002965A
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English (en)
French (fr)
Inventor
Dean Falb
Vincent M. Isabella
Jonathan W. Kotula
Paul F. Miller
Yves Millet
Adam Fisher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synlogic Operating Co Inc
Original Assignee
Synlogic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/998,376 external-priority patent/US20160206666A1/en
Priority claimed from PCT/US2016/020530 external-priority patent/WO2016141108A1/en
Application filed by Synlogic Inc filed Critical Synlogic Inc
Publication of CA3002965A1 publication Critical patent/CA3002965A1/en
Pending legal-status Critical Current

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    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
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US14/998,376 2015-12-22
US14/998,376 US20160206666A1 (en) 2014-12-22 2015-12-22 Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tighten gut mucosal barrier
US201662291461P 2016-02-04 2016-02-04
US201662291470P 2016-02-04 2016-02-04
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