CA3002962A1 - Protein quantitation in multicellular tissue specimens - Google Patents

Protein quantitation in multicellular tissue specimens Download PDF

Info

Publication number
CA3002962A1
CA3002962A1 CA3002962A CA3002962A CA3002962A1 CA 3002962 A1 CA3002962 A1 CA 3002962A1 CA 3002962 A CA3002962 A CA 3002962A CA 3002962 A CA3002962 A CA 3002962A CA 3002962 A1 CA3002962 A1 CA 3002962A1
Authority
CA
Canada
Prior art keywords
protein
component
biospecimen
heterogeneous
amount
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3002962A
Other languages
English (en)
French (fr)
Inventor
Daniel C. Liebler
Lisa J. Zimmerman
Robbert J.C. Slebos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vanderbilt University
Original Assignee
Vanderbilt University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vanderbilt University filed Critical Vanderbilt University
Publication of CA3002962A1 publication Critical patent/CA3002962A1/en
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA3002962A 2015-11-05 2016-04-20 Protein quantitation in multicellular tissue specimens Pending CA3002962A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562251604P 2015-11-05 2015-11-05
US62/251,604 2015-11-05
PCT/US2016/028426 WO2017078787A1 (en) 2015-11-05 2016-04-20 Protein quantitation in multicellular tissue specimens

Publications (1)

Publication Number Publication Date
CA3002962A1 true CA3002962A1 (en) 2017-05-11

Family

ID=58662934

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3002962A Pending CA3002962A1 (en) 2015-11-05 2016-04-20 Protein quantitation in multicellular tissue specimens

Country Status (5)

Country Link
US (1) US11047860B2 (https=)
EP (1) EP3371605B1 (https=)
JP (1) JP6742034B2 (https=)
CA (1) CA3002962A1 (https=)
WO (1) WO2017078787A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021055894A1 (en) * 2019-09-19 2021-03-25 Janssen Biotech, Inc. Materials and methods for differential characterization of molecular conjugates and conjugation
US20220011318A1 (en) * 2020-06-18 2022-01-13 Regeneron Pharmaceuticals, Inc. Heavy peptide approach to accurately measure unprocessed c-terminal lysine in antibodies
CN112150044B (zh) * 2020-11-04 2022-04-22 南京大学 基于高分辨率质谱的污水厂含氮有机物去除效果评价方法
US20240295561A1 (en) * 2021-06-17 2024-09-05 Konica Minolta, Inc. Quantification method and labeling method

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5725481A (en) * 1996-05-17 1998-03-10 A. Fem Medical Corporation Method and apparatus for collecting vaginal fluid and exfoliated vaginal cells for diagnostic purposes
AU2004303448A1 (en) * 2003-12-23 2005-07-07 Mount Sinai Hospital Methods for detecting markers associated with endometrial disease or phase
US20070019854A1 (en) 2005-05-10 2007-01-25 Bioimagene, Inc. Method and system for automated digital image analysis of prostrate neoplasms using morphologic patterns
JP5240739B2 (ja) * 2007-04-13 2013-07-17 オーエスアイ・フアーマシユーテイカルズ・エル・エル・シー キナーゼ阻害剤に対する抗癌応答を予測する生物学的マーカー
CA2749601C (en) 2009-01-14 2020-07-21 Stephen M. Hewitt Ratio based biomarkers and methods of use thereof
EP2309262A1 (en) 2009-10-06 2011-04-13 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Method for quantifying biomolecules
WO2013165598A1 (en) * 2012-04-30 2013-11-07 The Research Foundation For Suny Cancer blood test using bc200 rna isolated from peripheral blood for diagnosis and treatment of invasive breast cancer
WO2014085826A2 (en) * 2012-11-30 2014-06-05 Applied Proteomics, Inc. Method for evaluation of presence of or risk of colon tumors
EP3092495B1 (en) 2014-01-06 2020-11-25 Expression Pathology, Inc. Srm assay for pd-l1

Also Published As

Publication number Publication date
US11047860B2 (en) 2021-06-29
EP3371605A1 (en) 2018-09-12
JP2018536175A (ja) 2018-12-06
US20190154699A1 (en) 2019-05-23
EP3371605A4 (en) 2019-05-01
WO2017078787A1 (en) 2017-05-11
JP6742034B2 (ja) 2020-08-19
EP3371605B1 (en) 2021-06-23

Similar Documents

Publication Publication Date Title
US11624083B2 (en) Use of aptamers in proteomics
Kennedy et al. Demonstrating the feasibility of large-scale development of standardized assays to quantify human proteins
MacMullan et al. Quantitative proteomics and metabolomics reveal biomarkers of disease as potential immunotherapy targets and indicators of therapeutic efficacy
KR101595305B1 (ko) Ｔｉａｂｓ의 조성물 및 검출 방법
KR101658347B1 (ko) 폐암 바이오마커 및 그것들의 용도
DK2486405T3 (en) A method for the quantitative determination of biomolecules
Selevsek et al. Systematic quantification of peptides/proteins in urine using selected reaction monitoring
CN102027373A (zh) 发现用于前列腺癌诊断和治疗之生物标志物和药物靶标的方法及其确立的生物标志物测定
CN105177119A (zh) 用于测定抗egfr抗体在癌症治疗中的功效的生物标记和方法
US20170299605A1 (en) Srm methods in alzheimer's disease and neurological disease assays
Wang et al. Optimized data-independent acquisition approach for proteomic analysis at single-cell level
Umelo et al. Innovative methods for biomarker discovery in the evaluation and development of cancer precision therapies
US11047860B2 (en) Protein quantitation in multicellular tissue specimens
JP2019058171A (ja) Ｐｄ−ｌ１に対するｓｒｍアッセイ
JP6645981B2 (ja) サーマルシフトアッセイを使用して薬物反応の減少の指標となるバイオマーカーを識別するための方法
Wouters Proteomics: methodologies and applications in oncology
CN113330312B (zh) 评估生物样品中与分子效应相关的分子变化的方法
WO2017040404A1 (en) A method of detecting molecules in proximity to a target molecule in a sample
Lei et al. The breast cancer proteome and precision oncology
Liu et al. Multiplexed Data-Independent Acquisition (mDIA) to Profile Extracellular Vesicle Proteomes
Mahajan et al. Evolving stratification and biomarker discovery in cancer research with technological advancement of proteomics: 35 years and counting
CN106093241A (zh) 可用于检测喉癌的标志物及其用途
Buczak Spatial proteomics: from tissue organization to protein function
Blackler et al. Companion and complementary diagnostics by mass spectrometry
Mostolizadeh Quantification of Her2 Expression in Her2-low Tumors by Targeted Mass Spectrometry

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20210326