CA3002587A1 - Single-chain light receptor agonist proteins - Google Patents

Single-chain light receptor agonist proteins Download PDF

Info

Publication number
CA3002587A1
CA3002587A1 CA3002587A CA3002587A CA3002587A1 CA 3002587 A1 CA3002587 A1 CA 3002587A1 CA 3002587 A CA3002587 A CA 3002587A CA 3002587 A CA3002587 A CA 3002587A CA 3002587 A1 CA3002587 A1 CA 3002587A1
Authority
CA
Canada
Prior art keywords
light
receptor agonist
seq
protein
domain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA3002587A
Other languages
English (en)
French (fr)
Inventor
Christian Gieffers
Oliver Hill
Meinolf Thiemann
Tim SCHNYDER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Apogenix AG
Original Assignee
Apogenix AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apogenix AG filed Critical Apogenix AG
Publication of CA3002587A1 publication Critical patent/CA3002587A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA3002587A 2015-10-23 2016-10-24 Single-chain light receptor agonist proteins Abandoned CA3002587A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562245943P 2015-10-23 2015-10-23
US62/245,943 2015-10-23
PCT/EP2016/075536 WO2017068180A1 (en) 2015-10-23 2016-10-24 Single-chain light receptor agonist proteins

Publications (1)

Publication Number Publication Date
CA3002587A1 true CA3002587A1 (en) 2017-04-27

Family

ID=57206257

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3002587A Abandoned CA3002587A1 (en) 2015-10-23 2016-10-24 Single-chain light receptor agonist proteins

Country Status (7)

Country Link
US (2) US10683332B2 (https=)
EP (1) EP3365361A1 (https=)
JP (1) JP6873119B2 (https=)
CN (1) CN108699129A (https=)
AU (1) AU2016342420B2 (https=)
CA (1) CA3002587A1 (https=)
WO (1) WO2017068180A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017068183A1 (en) * 2015-10-23 2017-04-27 Apogenix Ag Single-chain cd137-receptor agonist proteins
EP3866846A4 (en) * 2018-10-17 2022-08-31 Albert Einstein College of Medicine METHOD OF INCREASING ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY (ADCC)
EP4149964A2 (en) 2020-05-15 2023-03-22 Apogenix AG Multi-specific immune modulators
EP4255464A4 (en) * 2020-12-03 2025-02-26 Shattuck Labs, Inc. METHODS OF TREATING CANCER USING CHIMERIC PROTEINS FORMED FROM TIGIT AND LIGHT
WO2023088876A1 (en) 2021-11-16 2023-05-25 Apogenix Ag Multi-specific immune modulators
CN114632156B (zh) * 2022-05-17 2022-08-16 中国人民解放军军事科学院军事医学研究院 Tim-3在预防、治疗或减轻疼痛中的应用
JP2025521227A (ja) * 2022-06-08 2025-07-08 ギリアード サイエンシーズ， インコーポレイテッド Ｌｉｇｈｔムテイン及びその使用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7645700A (en) 1999-10-07 2001-05-10 Maxygen Aps Single-chain antagonist polypeptides
DE19963859A1 (de) 1999-12-30 2001-07-12 Apotech Res & Dev Ltd Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen
CA2314199A1 (en) 2000-07-21 2002-01-21 Robert Simoneau C-chip
CA2520138C (en) 2003-03-26 2017-05-23 Apogenix Gmbh Improved fc fusion proteins
DE102004014983A1 (de) 2004-03-26 2005-10-20 Univ Stuttgart Rekombinante Polypeptide der Mitglieder der TNF Ligandenfamilie und deren Verwendung
JP2008528006A (ja) * 2005-01-28 2008-07-31 アポロ ライフ サイエンシズ リミテッド 分子およびそのキメラ分子
CN101160322A (zh) * 2005-01-28 2008-04-09 阿波罗生命科学有限公司 分子及其嵌合分子
JP2008537941A (ja) * 2005-03-31 2008-10-02 ゼンコー・インコーポレイテッド 最適化特性を有するＦｃ変異体
DK2604693T3 (en) * 2008-07-21 2016-05-30 Apogenix Gmbh Single-chain TNFSF molecules
EP3010547B1 (en) * 2013-06-20 2021-04-21 Innate Pharma Enzymatic conjugation of polypeptides
NO2776305T3 (https=) * 2014-04-23 2018-01-27
US10428149B2 (en) * 2015-03-18 2019-10-01 Universitat Stuttgart Single-chain tumor necrosis factor (TNF) ligand family molecules, fusion proteins and derivatives thereof

Also Published As

Publication number Publication date
JP2018533948A (ja) 2018-11-22
US20200331979A1 (en) 2020-10-22
AU2016342420B2 (en) 2020-10-01
US20180251509A1 (en) 2018-09-06
WO2017068180A1 (en) 2017-04-27
EP3365361A1 (en) 2018-08-29
US10683332B2 (en) 2020-06-16
AU2016342420A1 (en) 2018-04-26
JP6873119B2 (ja) 2021-05-19
CN108699129A (zh) 2018-10-23

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20210428

FZDE Discontinued

Effective date: 20230912