CA3001890A1 - Selective nr2b antagonists - Google Patents
Selective nr2b antagonists Download PDFInfo
- Publication number
- CA3001890A1 CA3001890A1 CA3001890A CA3001890A CA3001890A1 CA 3001890 A1 CA3001890 A1 CA 3001890A1 CA 3001890 A CA3001890 A CA 3001890A CA 3001890 A CA3001890 A CA 3001890A CA 3001890 A1 CA3001890 A1 CA 3001890A1
- Authority
- CA
- Canada
- Prior art keywords
- water
- column
- mmol
- acetonitrile
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3308DE2015 | 2015-10-14 | ||
| IN3308/DEL/2015 | 2015-10-14 | ||
| PCT/US2016/056714 WO2017066366A1 (en) | 2015-10-14 | 2016-10-13 | Selective nr2b antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3001890A1 true CA3001890A1 (en) | 2017-04-20 |
Family
ID=57223768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3001890A Abandoned CA3001890A1 (en) | 2015-10-14 | 2016-10-13 | Selective nr2b antagonists |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10344020B2 (OSRAM) |
| EP (1) | EP3362441B1 (OSRAM) |
| JP (1) | JP6938485B2 (OSRAM) |
| KR (1) | KR20180063306A (OSRAM) |
| CN (1) | CN108137543B (OSRAM) |
| AU (1) | AU2016340237A1 (OSRAM) |
| BR (1) | BR112018006537A2 (OSRAM) |
| CA (1) | CA3001890A1 (OSRAM) |
| EA (1) | EA201890946A1 (OSRAM) |
| ES (1) | ES2818254T3 (OSRAM) |
| IL (1) | IL258603A (OSRAM) |
| MX (1) | MX2018004256A (OSRAM) |
| WO (1) | WO2017066366A1 (OSRAM) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20230116865A (ko) * | 2020-12-04 | 2023-08-04 | 노파르티스 아게 | 우울증의 치료를 위한 nr2b-nmda 수용체 nam의 투여요법 |
| US11646085B2 (en) | 2021-06-17 | 2023-05-09 | Sandisk Technologies Llc | Toggle mode frequency optimization by dynamic ODT matching for non-volatile memory |
| CN116354923B (zh) * | 2021-12-27 | 2025-05-09 | 江苏恩华药业股份有限公司 | 一种含氮杂环化合物及其应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6960589B2 (en) | 2001-03-09 | 2005-11-01 | Abbott Laboratories | Benzimidazoles that are useful in treating sexual dysfunction |
| US7022728B2 (en) * | 2001-03-09 | 2006-04-04 | Abbott Laboratories | Benzimidazoles that are useful in treating male sexual dysfunction |
| EP1648882B1 (en) | 2003-06-04 | 2008-08-06 | Merck & Co., Inc. | 3-fluoro-piperidines as nmda/nr2b antagonists |
| EP1988077A4 (en) * | 2006-02-23 | 2009-09-02 | Shionogi & Co | NUCLEIC HETEROCYCLIC DERIVATIVES SUBSTITUTED BY CYCLIC GROUPS |
| KR20100045983A (ko) | 2007-06-29 | 2010-05-04 | 에모리 유니버시티 | 신경보호를 위한 ｎｍｄａ 수용체 길항물질 |
| JP2009067784A (ja) * | 2007-08-21 | 2009-04-02 | Shionogi & Co Ltd | 環式基で置換された含窒素複素環誘導体を含有する鎮痛剤 |
| EP2163541A1 (en) | 2008-09-12 | 2010-03-17 | Bayer Schering Pharma Aktiengesellschaft | Piperazine derivatives for binding and imaging amyloid plaques and their use |
| CN102933226A (zh) | 2010-02-11 | 2013-02-13 | 西北大学 | 二级结构稳定化的nmda受体调节剂及其用途 |
| US9624170B2 (en) * | 2013-12-26 | 2017-04-18 | Takeda Pharmaceutical Company Limited | 4-(piperrazin-1-yl)-pyrrolidin-2-one compounds as monoacylglycerol lipase (MAGL) inhibitors |
| US9187506B2 (en) * | 2014-01-09 | 2015-11-17 | Bristol-Myers Squibb Company | (R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one and its prodrugs for the treatment of psychiatric disorders |
| US9221796B2 (en) * | 2014-01-09 | 2015-12-29 | Bristol-Myers Squibb Company | Selective NR2B antagonists |
| ES2822830T3 (es) * | 2015-10-14 | 2021-05-05 | Bristol Myers Squibb Co | Antagonistas selectivos de NR2B |
-
2016
- 2016-10-13 WO PCT/US2016/056714 patent/WO2017066366A1/en not_active Ceased
- 2016-10-13 AU AU2016340237A patent/AU2016340237A1/en not_active Abandoned
- 2016-10-13 CA CA3001890A patent/CA3001890A1/en not_active Abandoned
- 2016-10-13 BR BR112018006537A patent/BR112018006537A2/pt not_active Application Discontinuation
- 2016-10-13 EP EP16790475.4A patent/EP3362441B1/en active Active
- 2016-10-13 ES ES16790475T patent/ES2818254T3/es active Active
- 2016-10-13 MX MX2018004256A patent/MX2018004256A/es unknown
- 2016-10-13 JP JP2018519321A patent/JP6938485B2/ja active Active
- 2016-10-13 EA EA201890946A patent/EA201890946A1/ru unknown
- 2016-10-13 KR KR1020187013126A patent/KR20180063306A/ko not_active Abandoned
- 2016-10-13 CN CN201680060583.4A patent/CN108137543B/zh active Active
- 2016-10-13 US US15/767,386 patent/US10344020B2/en active Active
-
2018
- 2018-04-10 IL IL258603A patent/IL258603A/en unknown
-
2019
- 2019-07-03 US US16/502,684 patent/US10961229B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| IL258603A (en) | 2018-06-28 |
| JP2018536637A (ja) | 2018-12-13 |
| EP3362441A1 (en) | 2018-08-22 |
| US20180312491A1 (en) | 2018-11-01 |
| EA201890946A1 (ru) | 2018-09-28 |
| US10344020B2 (en) | 2019-07-09 |
| KR20180063306A (ko) | 2018-06-11 |
| AU2016340237A1 (en) | 2018-05-31 |
| ES2818254T3 (es) | 2021-04-09 |
| EP3362441B1 (en) | 2020-08-12 |
| CN108137543A (zh) | 2018-06-08 |
| JP6938485B2 (ja) | 2021-09-22 |
| CN108137543B (zh) | 2021-11-23 |
| WO2017066366A1 (en) | 2017-04-20 |
| MX2018004256A (es) | 2018-05-16 |
| US20200071304A1 (en) | 2020-03-05 |
| US10961229B2 (en) | 2021-03-30 |
| BR112018006537A2 (pt) | 2018-10-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20201015 |