CA2998042C - Dactinomycin compositions and methods for the treatment of acute myeloid leukemia - Google Patents
Dactinomycin compositions and methods for the treatment of acute myeloid leukemia Download PDFInfo
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- CA2998042C CA2998042C CA2998042A CA2998042A CA2998042C CA 2998042 C CA2998042 C CA 2998042C CA 2998042 A CA2998042 A CA 2998042A CA 2998042 A CA2998042 A CA 2998042A CA 2998042 C CA2998042 C CA 2998042C
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- dactinomycin
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| PCT/EP2016/071599 WO2017046108A1 (en) | 2015-09-14 | 2016-09-13 | Dactinomycin compositions and methods for the treatment of acute myeloid leukemia |
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| JP7001599B2 (ja) | 2015-09-14 | 2022-01-19 | ファリーニ， ブルナンジェロ | 急性骨髄性白血病の処置のためのダクチノマイシン組成物および方法 |
| US10973773B2 (en) | 2016-09-13 | 2021-04-13 | Tiziana Life Sciences Plc | Dactinomycin compositions and methods for the treatment of myelodysplastic syndrome and acute myeloid leukemia |
| WO2018175746A1 (en) | 2017-03-24 | 2018-09-27 | Kura Oncology, Inc. | Methods for treating hematological malignancies and ewing's sarcoma |
| KR101954370B1 (ko) | 2018-07-25 | 2019-03-05 | 한미약품 주식회사 | 피리미딘 화합물 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물 |
| JP2022503792A (ja) * | 2018-09-26 | 2022-01-12 | クラ オンコロジー，インク． | メニン阻害剤を用いた血液悪性腫瘍の処置 |
| PH12021551985A1 (en) | 2019-02-22 | 2022-08-22 | Hanmi Pharmaceutical Co Ltd | Pharmaceutical composition comprising flt3 inhibitor and hypomethylating agent for treating acute myeloid leukemia |
| WO2020262974A1 (ko) | 2019-06-27 | 2020-12-30 | 한미약품 주식회사 | Flt3 저해제 및 화학치료제를 포함하는 급성 골수성 백혈병 치료용 약학적 조성물 |
| KR102886965B1 (ko) * | 2022-02-28 | 2025-11-17 | 한국유나이티드제약 주식회사 | 향상된 용해도를 가지는 닥티노마이신 함유 약학조성물의 제조방법 |
| WO2024124199A1 (en) * | 2022-12-10 | 2024-06-13 | Aptose Biosciences Inc. | Methods for treating patients with hematologic malignancies |
| CN116942834B (zh) * | 2023-06-12 | 2024-04-05 | 新乡医学院 | 包含核仁应激诱导剂的抗肿瘤药物 |
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| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
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| US20070010478A1 (en) * | 2005-07-06 | 2007-01-11 | Branimir Sikic | Zosuquidar, daunorubicin, and cytarabine for the treatment of cancer |
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| US11077139B2 (en) | 2013-12-30 | 2021-08-03 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Combination of an arsenic compound and at least one retinoid for treating acute myeloid leukemia |
| JP7001599B2 (ja) | 2015-09-14 | 2022-01-19 | ファリーニ， ブルナンジェロ | 急性骨髄性白血病の処置のためのダクチノマイシン組成物および方法 |
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| JP7001599B2 (ja) | 2022-01-19 |
| CA2998042A1 (en) | 2017-03-23 |
| EP3349759B1 (en) | 2020-05-20 |
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| US11337983B2 (en) | 2022-05-24 |
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| US20190314380A1 (en) | 2019-10-17 |
| US20180207168A1 (en) | 2018-07-26 |
| WO2017046108A1 (en) | 2017-03-23 |
| EP3349759A1 (en) | 2018-07-25 |
| US10335416B2 (en) | 2019-07-02 |
| ES2809805T3 (es) | 2021-03-05 |
| AU2016324920B2 (en) | 2022-03-03 |
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