CA2989926C - Non-carcinogenic cream for delivery of active ingredient into the dermis - Google Patents
Non-carcinogenic cream for delivery of active ingredient into the dermis Download PDFInfo
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- CA2989926C CA2989926C CA2989926A CA2989926A CA2989926C CA 2989926 C CA2989926 C CA 2989926C CA 2989926 A CA2989926 A CA 2989926A CA 2989926 A CA2989926 A CA 2989926A CA 2989926 C CA2989926 C CA 2989926C
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- SNBXCWVOMQIJEH-UHFFFAOYSA-K calcium;potassium;hydroxide;sulfate Chemical compound [OH-].[K+].[Ca+2].[O-]S([O-])(=O)=O SNBXCWVOMQIJEH-UHFFFAOYSA-K 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 235000010708 frostweed Nutrition 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 230000036449 good health Effects 0.000 description 1
- 230000009442 healing mechanism Effects 0.000 description 1
- 235000010181 horse chestnut Nutrition 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 238000013160 medical therapy Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229940049964 oleate Drugs 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000008058 pain sensation Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 210000000697 sensory organ Anatomy 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Health & Medical Sciences (AREA)
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- Microbiology (AREA)
- Mycology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
INGREDIENT INTO THE DERMIS
BACKGROUND
(a) Field [0001] The subject matter disclosed generally relates to a non-carcinogenic cream for delivery of active ingredients into the dermis of a patient for pain related to joint, lymphatic and blood circulation, nerve and skin.
(b) Related Prior Art
File No. P4334CA00 Many injuries have a multiplicity of symptoms which require a cocktail of ingredients working together in order to provide relief.
Date Recue/Date Received 2022-09-29 File No. P4334CA00
SUMMARY
= about 12.8% of emulsifier;
= about 1.05% of preservative; and = about 65.67% of water; and = about 4.78% the homeopathic active ingredient comprises at least pancreatinum, ruta graveolens, ledum palustre, colchicum autumnale, symphytum officinalis, arnica montana, atropa belladonna, achillea millefolium, hamamelis, mercurius solubilis, mercurius iodatus, conium maculatum, echinacea angustifolia, echinacea purpurea, aconitum napellus, hypericum perforatum, bellis perennis, matricaria chamomilla, calendula officinalis and hepar sulphur's.
O a second ingredient chosen from at least one of arnica montana, atropa belladonna, achillea millefolium or hamamelis;
O a third ingredient chosen from at least one of mercurius solubilis, mercurius iodatus, conium maculatum, echinacea angustifolia or echinacea purpurea;
O a fourth ingredient chosen from at least one perennis, matricaria chamomilla, gallium aparine, phytolacca decandra, scrofularia nosada, or pulsatilla;
O a fifth ingredient chosen from at least one of pancreatinum, calendula officinalis, hepar sulphuris, somniferrum, calcarea fluorica, thiosinaminum, hydrastis, arctium lappa, gallium aparine, urtica urens, aloe, graphite, or petroleum.
Accordingly, the drawings and the description are to be regarded as illustrative in nature, and not as restrictive and the full scope of the subject matter is set forth in the claims.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
File No. P4334CA00
This restores blood flow to the inflammed areas where most of the pain is File No. P4334CA00 realized. When blood flow is improved to an ailing joint, healing begins and true pain relief is realized.
Mate extract is commercially available in combination with extracts of Kola and Guarana which is sold by Cosmetic Ingredient Resources of Stamford under the trademark "QUENCHT."
Cream to treat pain
= 12.7% of a synergistic combination of emu oil, olive oil, argan nut oil, sunflower/safflower oil and coconut oil;
= 15.8% of a synergistic combination of coleyl oleate and cetearyl alcohol;
= 1.05% of a synergistic combination of glucose, glucose oxidase and lactoperoxidase;
File No. P4334CA00 = 65.67% of water and = 4.78% of a combination of homeopathic extracts containing:
O 0.05 % by weight of pancreatinum, O 0.01% by weight of ruta graveolens, O 0.01% by weight of ledum palustre, O 0.1% by weight of colchicum autumnale, O 0.1% by weight of symphytum officinal's, O 1.5% by weight of arnica montana, O 0.5% by weight of atropa belladonna, O 0.07% by weight of achillea millefolium, O 0.45% by weight of hamamelis, O 0.04% by weight of mercurius solubilis, O 0.01% by weight of mercurius iodatus, O 0.1% by weight of conium maculatum, o 0.15% by weight of echinacea angustifolia, O 0.15% by weight of echinacea purpurea, O 0.5% by weight of aconitum napellus, O 0.09% by weight of hypericum perforatum, o 0.1% by weight of bellis perennis, O 0.15% by weight of matricaria chamomilla, O 0.45% by weight of calendula officinalis and O 0.25% by weight of hepar sulphuris.
Cream to treat pain File No. P4334CA00
= 14.7% of a synergistic combination of emu oil, olive oil, argon nut oil, sunflower/safflower oil and coconut oil;
= 12.8% of a synergistic combination of oleyl oleate and cetearyl alcohol;
= 1.05% of a synergistic combination of benzyl alcohol, salicylic acid, glycerin and sorbic acid;
= 65.67% of water and = 4.78% of a combination of homeopathic extracts containing:
O 0.05 % by weight of pancreatinum, O 0.01% by weight of ruta graveolens, o 0.01% by weight of ledum palustre, O 0.1% by weight of colchicum autumnale, O 0.1% by weight of symphytum offleinalis, o 1.5% by weight of arnica montana, O 0.5% by weight of atropa belladonna, O 0.07% by weight of achillea millefolium, = 0.45% by weight of hamamelis, O 0.04% by weight of mercurius solubilis, O 0.01% by weight of mercurius iodatus, O 0.1% by weight of conium maculatum, O 0.15% by weight of echinacea angustifolia, O 0.15% by weight of echinacea purpurea, O 0.5% by weight of aconitum napellus, O 0.09% by weight of hypericum perforatum, File No. P4334CA00 O 0.1% by weight of bellis perennis, o 0.15% by weight of matricaria chamomilla, O 0.45% by weight of calendula officinalis and O 0.25% by weight of hepar sulphuris.
While preferred embodiments have been described above and illustrated in the accompanying drawings, it will be evident to those skilled in the art that modifications may be made without departing from this disclosure. Such modifications are considered as possible variants comprised in the scope of the disclosure.
Claims (6)
cream for delivery of active ingredients in the derm is of a patient, which comprises a combination of = about 10 to about 25% by weight of oil = about 10 to about 25% by weight of emulsifier = about 1 to about 12% by weight of preservative = about 45 to about 80% by weight of water, aloe water or hamamelis water;
and = about 1 to about 25% by weight of a combination of at least five homeopathic active ingredients comprising:
O a first ingredient for improving joint conditions chosen from one of ruta graveolens, ledum palustre, colchicum autumnale, symphytum officinalis, salix alba, harpagophytum, bryonia, capsicum, rhododendron, benzoic acid, salicilicum acid or a combination thereof;
O a second ingredient for improving blood circulation chosen from one of arnica montana, atropa belladonna, achillea millefolium, hamamelis, agaricus, aesculus or a combination thereof;
O a third ingredient for improving lymphatic circulation chosen from one of mercurius solubilis, mercurius iodatus, conium maculatum, echinacea angustifolia, echinacea purpurea, gallium aparine, phytolacca decandra, scrofularia nosada, pulsatilla, or a combination thereof;
O a fourth ingredient for improving sensitive nerves chosen from aconitum napellus, hypericum perforatum, bellis perennis, matricaria chamomilla, ranunculus, phytolacca decandra, dulcamara solanum, kalmia, actea racemosa, spigelia, gnaphalium, or a combination thereof; and O a fifth ingredient for reducing scars and/or keloids of the skin chosen from pancreatinum, calendula officinalis, hepar sulphuric, somniferrum, calcarea fluorica, thiosinaminum, hydrastis, arctium lappa, gallium aparine, urtica urens, aloe, graphite, petroleum or a combination thereof.
Date recue/Date received 2023-06-05
= about 14% by weight of emulsifier;
= about 1% by weight of preservative; and = about 66% by weight of water; and = about 5% by weight of the homeopathic active ingredient which comprises at least pancreatinum, ruta graveolens, ledum palustre, colchicum autumnale, symphytum officinalis, arnica montana, atropa belladonna, achillea millefolium, hamamelis, mercurius solubilis, mercurius iodatus, conium maculatum, echinacea angustifolia, echinacea purpurea, aconitum napellus, hypericum perforatum, bellis perennis, matricaria chamomilla, calendula officinalis and hepar sulphuris.
Date recue/Date received 2023-06-05
Use of the cream of any one of claims 1-5 as a topical-based treatment for improving joint conditions, blood circulation, lymphatic circulation, sensitive nerves, and reducing scars and/or keloids of the skin and promoting granulation tissue growth wherein - joint conditions in a patient comprises pain, stiffness, sprain, strain, swelling, inflammation, wound and injury;
- blood circulation in a patient comprises pain, muscle elongations and/or contractions, congestion, capillary distension, swelling, inflammation, bruise, wound and injury;
- lymphatic circulation in a patient comprises pain, congestion of lymphatic system, glandular swelling, bruise, stiffness, muscular weakness, lymphatic inflammation, wound and injury; and - sensitive nerves conditions in a patient comprises pain, joint swelling, irritation in joint and/or muscle, nerve contraction, wound and injury.
Date Recue/Date Received 2023-09-20
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