CA2986769A1 - Utilisation de therapie par cellules encapsulees pour le traitement de troubles ophtalmiques - Google Patents

Utilisation de therapie par cellules encapsulees pour le traitement de troubles ophtalmiques Download PDF

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Publication number
CA2986769A1
CA2986769A1 CA2986769A CA2986769A CA2986769A1 CA 2986769 A1 CA2986769 A1 CA 2986769A1 CA 2986769 A CA2986769 A CA 2986769A CA 2986769 A CA2986769 A CA 2986769A CA 2986769 A1 CA2986769 A1 CA 2986769A1
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Prior art keywords
cells
biologically active
cntf
eye
membrane
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Pending
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CA2986769A
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English (en)
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Jeffrey Louis Goldberg
Cahil MCGOVERN
Weng Tao
Konrad Kauper
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Neurotech USA Inc
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Neurotech USA Inc
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Publication of CA2986769A1 publication Critical patent/CA2986769A1/fr
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • A61K9/0051Ocular inserts, ocular implants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/185Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • A61K38/2066IL-10
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/21Interferons [IFN]
    • A61K38/212IFN-alpha
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/21Interferons [IFN]
    • A61K38/215IFN-beta
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816Wall or shell material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Developmental Biology & Embryology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Virology (AREA)
  • Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention concerne des procédés et des dispositifs pour le traitement à long terme de troubles ophtalmiques. L'invention concerne également des dispositifs de thérapie par cellules encapsulées (ECT), qui sécrètent une molécule biologiquement active, ainsi que leurs procédés d'utilisation pour le traitement de divers types de troubles ophtalmiques, comprenant la rétinite pigmentaire, l'atrophie géographique (dégénérescence maculaire de type sec liée à l'âge), un glaucome et/ou la télangiectasie maculaire.
CA2986769A 2015-05-27 2016-05-27 Utilisation de therapie par cellules encapsulees pour le traitement de troubles ophtalmiques Pending CA2986769A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562167213P 2015-05-27 2015-05-27
US62/167,213 2015-05-27
PCT/US2016/034552 WO2016191645A1 (fr) 2015-05-27 2016-05-27 Utilisation de thérapie par cellules encapsulées pour le traitement de troubles ophtalmiques

Publications (1)

Publication Number Publication Date
CA2986769A1 true CA2986769A1 (fr) 2016-12-01

Family

ID=56133060

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2986769A Pending CA2986769A1 (fr) 2015-05-27 2016-05-27 Utilisation de therapie par cellules encapsulees pour le traitement de troubles ophtalmiques

Country Status (8)

Country Link
US (5) US10456356B2 (fr)
EP (2) EP3302524B1 (fr)
JP (2) JP6850734B2 (fr)
AU (1) AU2016267579B2 (fr)
CA (1) CA2986769A1 (fr)
ES (1) ES2833457T3 (fr)
IL (2) IL255917B (fr)
WO (1) WO2016191645A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10456356B2 (en) 2015-05-27 2019-10-29 Neurotech Usa, Inc. Use of encapsulated cell therapy for treatment of ophthalmic disorders
JP2021531328A (ja) * 2018-06-19 2021-11-18 セラ セラピューティクス エルエルシー 神経栄養剤、アポトーシスシグナリング断片化阻害剤(FAS)もしくはFASリガンド(FASL)阻害剤、腫瘍壊死因子α(TNF−α)もしくはTNF受容体阻害剤、ミトコンドリアペプチド、オリゴヌクレオチド、ケモカイン阻害剤、またはシステイン−アスパラギン酸プロテアーゼを含む薬剤送達系
CN112566622A (zh) * 2018-06-19 2021-03-26 细胞疗法有限责任公司 用于治疗青光眼或高眼压症的包含眼内压降低剂、cnp化合物、npr-b化合物、tie-2激动剂或神经营养剂的缓释药物递送系统
DE102018126842B4 (de) * 2018-10-26 2020-10-15 Carl Zeiss Meditec Ag Ophthalmologisches Implantat, Verfahren zum Herstellen eines ophthalmologischen Implantats und Verwendung eines Liganden zur Herstellung eines ophthalmologischen Implantats
US20220249700A1 (en) * 2019-05-13 2022-08-11 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Polymer-based implant for retinal therapy and methods of making and using the same
CA3156941A1 (fr) 2019-11-01 2021-05-06 Neurotech Usa, Inc. Systeme, appareils, dispositifs et methodes pour un dispositif implantable de diffusion d'analyte
KR20220118499A (ko) * 2019-12-18 2022-08-25 셀라 테라퓨틱스, 엘엘씨 신경영양제, 세포자멸 신호전달 단편 억제제(FAS) 또는 FAS 리간드(FASL) 억제제, 종양 괴사 인자-α(TNF-α) 또는 TNF 수용체 억제제, 미토콘드리아 펩티드, 올리고뉴클레오티드, 케모카인 억제제 또는 시스테인-아스파틱 프로테아제 억제제를 포함하는 약물 전달 시스템
CN111437725A (zh) * 2020-03-23 2020-07-24 天津工业大学 氧化石墨烯-聚乙二醇/聚偏氟乙烯复合超滤膜制备方法
CN116456963A (zh) 2020-11-02 2023-07-18 尼科斯股份有限公司 用于治疗干性年龄相关性黄斑变性、地图状萎缩和青光眼相关性神经变性的no-pde5抑制剂
WO2023201258A2 (fr) * 2022-04-12 2023-10-19 Avenge Bio, Inc. Cellules encapsulées et leurs procédés de conservation

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Also Published As

Publication number Publication date
AU2016267579A1 (en) 2017-12-07
ES2833457T3 (es) 2021-06-15
US10195140B2 (en) 2019-02-05
US20200197297A1 (en) 2020-06-25
IL283713A (en) 2021-07-29
JP2020200347A (ja) 2020-12-17
AU2016267579B2 (en) 2024-02-01
EP3302524B1 (fr) 2020-09-23
IL255917B (en) 2021-06-30
US20180055766A1 (en) 2018-03-01
US10456356B2 (en) 2019-10-29
US11207266B2 (en) 2021-12-28
US20220071897A1 (en) 2022-03-10
EP3302524A1 (fr) 2018-04-11
EP3662923A1 (fr) 2020-06-10
WO2016191645A1 (fr) 2016-12-01
JP2018515582A (ja) 2018-06-14
US20240285521A1 (en) 2024-08-29
IL255917A (en) 2018-01-31
JP7078683B2 (ja) 2022-05-31
IL283713B (en) 2022-03-01
JP6850734B2 (ja) 2021-03-31
US20160346197A1 (en) 2016-12-01

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