CA2983651A1 - Antibacterial compositions comprising copper oxo-hydroxide nanoparticles and their uses as biocidal agents - Google Patents
Antibacterial compositions comprising copper oxo-hydroxide nanoparticles and their uses as biocidal agentsInfo
- Publication number
- CA2983651A1 CA2983651A1 CA2983651A CA2983651A CA2983651A1 CA 2983651 A1 CA2983651 A1 CA 2983651A1 CA 2983651 A CA2983651 A CA 2983651A CA 2983651 A CA2983651 A CA 2983651A CA 2983651 A1 CA2983651 A1 CA 2983651A1
- Authority
- CA
- Canada
- Prior art keywords
- copper
- oxo
- hydroxide
- composition
- nanoparticles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000203 mixture Substances 0.000 title claims abstract 41
- 239000002105 nanoparticle Substances 0.000 title claims abstract 38
- VTGNXADCFUDPLG-UHFFFAOYSA-N O(O)O.[Cu] Chemical compound O(O)O.[Cu] VTGNXADCFUDPLG-UHFFFAOYSA-N 0.000 title claims abstract 33
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract 25
- 239000003139 biocide Substances 0.000 title 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims abstract 4
- 229910052802 copper Inorganic materials 0.000 claims abstract 4
- 239000010949 copper Substances 0.000 claims abstract 4
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 claims abstract 3
- 239000000463 material Substances 0.000 claims abstract 2
- 239000003446 ligand Substances 0.000 claims 15
- 238000000034 method Methods 0.000 claims 9
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 8
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 6
- 208000015181 infectious disease Diseases 0.000 claims 5
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims 4
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims 4
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 4
- 230000000813 microbial effect Effects 0.000 claims 4
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 3
- WLJVNTCWHIRURA-UHFFFAOYSA-N pimelic acid Chemical compound OC(=O)CCCCCC(O)=O WLJVNTCWHIRURA-UHFFFAOYSA-N 0.000 claims 3
- 235000002906 tartaric acid Nutrition 0.000 claims 3
- 239000011975 tartaric acid Substances 0.000 claims 3
- 208000035143 Bacterial infection Diseases 0.000 claims 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 claims 2
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims 2
- 108010024636 Glutathione Proteins 0.000 claims 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 claims 2
- 239000001361 adipic acid Substances 0.000 claims 2
- 235000011037 adipic acid Nutrition 0.000 claims 2
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 claims 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims 2
- 229940050410 gluconate Drugs 0.000 claims 2
- 239000000174 gluconic acid Substances 0.000 claims 2
- 235000012208 gluconic acid Nutrition 0.000 claims 2
- 229960003180 glutathione Drugs 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 239000011159 matrix material Substances 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims 1
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 claims 1
- 241000588626 Acinetobacter baumannii Species 0.000 claims 1
- 241000588625 Acinetobacter sp. Species 0.000 claims 1
- 241000194110 Bacillus sp. (in: Bacteria) Species 0.000 claims 1
- 235000014469 Bacillus subtilis Nutrition 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims 1
- 241000222122 Candida albicans Species 0.000 claims 1
- 241001495184 Chlamydia sp. Species 0.000 claims 1
- 241000193163 Clostridioides difficile Species 0.000 claims 1
- 241000193464 Clostridium sp. Species 0.000 claims 1
- 208000034423 Delivery Diseases 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 241000488157 Escherichia sp. Species 0.000 claims 1
- 206010017533 Fungal infection Diseases 0.000 claims 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 1
- 238000004566 IR spectroscopy Methods 0.000 claims 1
- 241000588754 Klebsiella sp. Species 0.000 claims 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 claims 1
- 241000191938 Micrococcus luteus Species 0.000 claims 1
- 241000191936 Micrococcus sp. Species 0.000 claims 1
- 241000187488 Mycobacterium sp. Species 0.000 claims 1
- 208000031888 Mycoses Diseases 0.000 claims 1
- 241000589774 Pseudomonas sp. Species 0.000 claims 1
- 241000607149 Salmonella sp. Species 0.000 claims 1
- 206010041925 Staphylococcal infections Diseases 0.000 claims 1
- 241000191967 Staphylococcus aureus Species 0.000 claims 1
- 241001147693 Staphylococcus sp. Species 0.000 claims 1
- 241000193996 Streptococcus pyogenes Species 0.000 claims 1
- 241000194022 Streptococcus sp. Species 0.000 claims 1
- 241000607284 Vibrio sp. Species 0.000 claims 1
- 206010052428 Wound Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 239000000084 colloidal system Substances 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 210000002615 epidermis Anatomy 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 229950006191 gluconic acid Drugs 0.000 claims 1
- 230000009036 growth inhibition Effects 0.000 claims 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 1
- 239000001630 malic acid Substances 0.000 claims 1
- 235000011090 malic acid Nutrition 0.000 claims 1
- 208000015688 methicillin-resistant staphylococcus aureus infectious disease Diseases 0.000 claims 1
- 229960003085 meticillin Drugs 0.000 claims 1
- 239000004745 nonwoven fabric Substances 0.000 claims 1
- 239000002244 precipitate Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 239000012429 reaction media Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000007790 solid phase Substances 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 1
- 239000001384 succinic acid Substances 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 201000008827 tuberculosis Diseases 0.000 claims 1
- 230000009677 vaginal delivery Effects 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 229910001431 copper ion Inorganic materials 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 230000009257 reactivity Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/30—Copper compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/34—Copper; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A61K9/0017—Non-human animal skin, e.g. pour-on, spot-on
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Otolaryngology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Urology & Nephrology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1507002.2 | 2015-04-24 | ||
| GBGB1507002.2A GB201507002D0 (en) | 2015-04-24 | 2015-04-24 | Copper Oxo-hydroxide nanoparticles and their uses as biocidal agents |
| PCT/EP2016/059074 WO2016170152A1 (en) | 2015-04-24 | 2016-04-22 | Antibacterial compositions comprising copper oxo-hydroxide nanoparticles and their uses as biocidal agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2983651A1 true CA2983651A1 (en) | 2016-10-27 |
Family
ID=53488605
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2983651A Abandoned CA2983651A1 (en) | 2015-04-24 | 2016-04-22 | Antibacterial compositions comprising copper oxo-hydroxide nanoparticles and their uses as biocidal agents |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20180147177A1 (enExample) |
| EP (1) | EP3285759B1 (enExample) |
| JP (1) | JP6775523B2 (enExample) |
| CN (1) | CN108064152B (enExample) |
| CA (1) | CA2983651A1 (enExample) |
| ES (1) | ES2767651T3 (enExample) |
| GB (1) | GB201507002D0 (enExample) |
| SG (1) | SG11201708618WA (enExample) |
| WO (1) | WO2016170152A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3789046A1 (en) | 2019-09-05 | 2021-03-10 | Nanordica Medical Oü | Biocompatible nanoparticles with various surface functionalization for antimicrobial applications |
| US20240081336A1 (en) * | 2019-09-16 | 2024-03-14 | Corning Incorporated | Color stabilization of biocidal coatings |
| US11247184B2 (en) | 2019-12-30 | 2022-02-15 | Marathon Petroleum Company Lp | Methods and systems for spillback control of in-line mixing of hydrocarbon liquids |
| US11559774B2 (en) | 2019-12-30 | 2023-01-24 | Marathon Petroleum Company Lp | Methods and systems for operating a pump at an efficiency point |
| US11607654B2 (en) | 2019-12-30 | 2023-03-21 | Marathon Petroleum Company Lp | Methods and systems for in-line mixing of hydrocarbon liquids |
| CA3103413C (en) | 2019-12-30 | 2023-04-25 | Marathon Petroleum Company Lp | Methods and systems for inline mixing of hydrocarbon liquids based on density or gravity |
| GB202005054D0 (en) | 2020-04-06 | 2020-05-20 | Nemysis Ltd | Carboxylate Ligand Modified Ferric Iron Hydroxide Compositions for Use in the Treatment or Prevention of Iron Deficiency Associated with Liver Diseases |
| CN111592032A (zh) * | 2020-05-09 | 2020-08-28 | 山东科技大学 | 抗菌氢氧化铜纳米线膜及其制备方法及其二次利用方法 |
| WO2021231702A1 (en) * | 2020-05-15 | 2021-11-18 | Rutgers, The State University Of New Jersey | Compositions and methods for treating wounds |
| US12012883B2 (en) | 2021-03-16 | 2024-06-18 | Marathon Petroleum Company Lp | Systems and methods for backhaul transportation of liquefied gas and CO2 using liquefied gas carriers |
| US11578836B2 (en) | 2021-03-16 | 2023-02-14 | Marathon Petroleum Company Lp | Scalable greenhouse gas capture systems and methods |
| US11655940B2 (en) | 2021-03-16 | 2023-05-23 | Marathon Petroleum Company Lp | Systems and methods for transporting fuel and carbon dioxide in a dual fluid vessel |
| US11578638B2 (en) | 2021-03-16 | 2023-02-14 | Marathon Petroleum Company Lp | Scalable greenhouse gas capture systems and methods |
| US12129559B2 (en) | 2021-08-26 | 2024-10-29 | Marathon Petroleum Company Lp | Test station assemblies for monitoring cathodic protection of structures and related methods |
| US11447877B1 (en) | 2021-08-26 | 2022-09-20 | Marathon Petroleum Company Lp | Assemblies and methods for monitoring cathodic protection of structures |
| US12043905B2 (en) | 2021-08-26 | 2024-07-23 | Marathon Petroleum Company Lp | Electrode watering assemblies and methods for maintaining cathodic monitoring of structures |
| US12180597B2 (en) | 2021-08-26 | 2024-12-31 | Marathon Petroleum Company Lp | Test station assemblies for monitoring cathodic protection of structures and related methods |
| US11686070B1 (en) | 2022-05-04 | 2023-06-27 | Marathon Petroleum Company Lp | Systems, methods, and controllers to enhance heavy equipment warning |
| CN116237532A (zh) * | 2022-12-22 | 2023-06-09 | 江南大学 | 一种糖基配体类似物诱导手性钴基超小纳米粒子的合成方法 |
| US12012082B1 (en) | 2022-12-30 | 2024-06-18 | Marathon Petroleum Company Lp | Systems and methods for a hydraulic vent interlock |
| US12043361B1 (en) | 2023-02-18 | 2024-07-23 | Marathon Petroleum Company Lp | Exhaust handling systems for marine vessels and related methods |
| US12006014B1 (en) | 2023-02-18 | 2024-06-11 | Marathon Petroleum Company Lp | Exhaust vent hoods for marine vessels and related methods |
| US12297965B2 (en) | 2023-08-09 | 2025-05-13 | Marathon Petroleum Company Lp | Systems and methods for mixing hydrogen with natural gas |
| US12220492B1 (en) | 2023-09-08 | 2025-02-11 | King Faisal University | Wound dressing based on polymeric mixture of cellulose acetate and hyaluronic acid embedded with copper oxide and magnesium oxide nanoparticles |
| US12087002B1 (en) | 2023-09-18 | 2024-09-10 | Marathon Petroleum Company Lp | Systems and methods to determine depth of soil coverage along a right-of-way |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5164367A (en) * | 1990-03-26 | 1992-11-17 | Procyte Corporation | Method of using copper(ii) containing compounds to accelerate wound healing |
| JP2004513905A (ja) * | 2000-11-16 | 2004-05-13 | ザイラー， ケネス ティー． | 抗真菌爪用組成物および使用方法 |
| AU2006314306A1 (en) * | 2005-11-17 | 2007-05-24 | Remedy Research Limited | Pathogen - controlling products |
| NZ567962A (en) * | 2006-04-24 | 2011-05-27 | Nm Tech Ltd Nanomaterials And Microdevices Technology | Functional nanomaterials with antibacterial and antiviral activity |
| US20080147019A1 (en) * | 2006-12-19 | 2008-06-19 | Kimberly-Clark Worldwide, Inc. | Antimicrobial component system containing metallic nanoparticles and chitosan and/or its derivatives |
| EA019635B1 (ru) * | 2007-02-06 | 2014-05-30 | Медикал Ресёрч Каунсил | Лиганд-модифицированные полиоксогидроксидные материалы с ионами металла, их применение и способы их получения |
| GB0702270D0 (en) * | 2007-02-06 | 2007-03-14 | Medical Res Council | Ligand modified poly oxo-hydroxy metal ion materials, their uses and processes for their preparation |
| IT1391668B1 (it) * | 2008-07-23 | 2012-01-17 | Universita' Degli Studi Di Trieste | Materiali nanocompositi basati su nanoparticelle metalliche stabilizzate con polisaccaridi a struttura ramificata. |
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| CN102631699A (zh) * | 2011-02-11 | 2012-08-15 | 佛山市优特医疗科技有限公司 | 含有纳米金属的抗菌性纤维类敷料及其制备方法 |
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| GB201207617D0 (en) * | 2012-05-02 | 2012-06-13 | Systagenix Wound Man Ip Co Bv | Wound dressings |
| US9255449B2 (en) * | 2012-07-30 | 2016-02-09 | Baker Hughes Incorporated | Drill bit with electrohydraulically adjustable pads for controlling depth of cut |
| US10398733B2 (en) * | 2013-03-15 | 2019-09-03 | Cda Research Group, Inc. | Topical copper ion treatments and methods of treatment using topical copper ion treatments in the dermatological areas of the body |
| GB201402672D0 (en) * | 2014-02-14 | 2014-04-02 | Medical Res Council | Materials and methods relating to stabilised polymeric silicate compositions |
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2015
- 2015-04-24 GB GBGB1507002.2A patent/GB201507002D0/en not_active Ceased
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2016
- 2016-04-22 ES ES16717670T patent/ES2767651T3/es active Active
- 2016-04-22 CA CA2983651A patent/CA2983651A1/en not_active Abandoned
- 2016-04-22 CN CN201680037392.6A patent/CN108064152B/zh not_active Expired - Fee Related
- 2016-04-22 EP EP16717670.0A patent/EP3285759B1/en active Active
- 2016-04-22 SG SG11201708618WA patent/SG11201708618WA/en unknown
- 2016-04-22 JP JP2017555479A patent/JP6775523B2/ja not_active Expired - Fee Related
- 2016-04-22 US US15/567,419 patent/US20180147177A1/en not_active Abandoned
- 2016-04-22 WO PCT/EP2016/059074 patent/WO2016170152A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP3285759B1 (en) | 2019-11-13 |
| EP3285759A1 (en) | 2018-02-28 |
| HK1245642A1 (en) | 2018-08-31 |
| JP6775523B2 (ja) | 2020-10-28 |
| CN108064152A (zh) | 2018-05-22 |
| US20180147177A1 (en) | 2018-05-31 |
| GB201507002D0 (en) | 2015-06-10 |
| CN108064152B (zh) | 2021-07-09 |
| ES2767651T3 (es) | 2020-06-18 |
| SG11201708618WA (en) | 2017-11-29 |
| WO2016170152A1 (en) | 2016-10-27 |
| JP2018513186A (ja) | 2018-05-24 |
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