CA2981288C - Amphotericin b derivative with reduced toxicity - Google Patents
Amphotericin b derivative with reduced toxicity Download PDFInfo
- Publication number
- CA2981288C CA2981288C CA2981288A CA2981288A CA2981288C CA 2981288 C CA2981288 C CA 2981288C CA 2981288 A CA2981288 A CA 2981288A CA 2981288 A CA2981288 A CA 2981288A CA 2981288 C CA2981288 C CA 2981288C
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- Prior art keywords
- epiamb
- amb
- mmol
- equiv
- yeast
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- 230000002829 reductive effect Effects 0.000 title abstract description 17
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461994450P | 2014-05-16 | 2014-05-16 | |
| US61/994,450 | 2014-05-16 | ||
| US201462045907P | 2014-09-04 | 2014-09-04 | |
| US62/045,907 | 2014-09-04 | ||
| PCT/US2015/030965 WO2015175875A1 (en) | 2014-05-16 | 2015-05-15 | Amphotericin b derivative with reduced toxicity |
Publications (2)
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| CA2981288A1 CA2981288A1 (en) | 2015-11-19 |
| CA2981288C true CA2981288C (en) | 2022-12-06 |
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| CA2981288A Active CA2981288C (en) | 2014-05-16 | 2015-05-15 | Amphotericin b derivative with reduced toxicity |
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| EP (1) | EP3142672B1 (enExample) |
| JP (1) | JP6543272B2 (enExample) |
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| DK (1) | DK3142672T3 (enExample) |
| ES (1) | ES2749927T3 (enExample) |
| WO (1) | WO2015175875A1 (enExample) |
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| WO2016061437A1 (en) | 2014-10-17 | 2016-04-21 | The Board Of Trustees Of The University Of Illinois | Scalable synthesis of reduced toxicity derivative of amphotericin b |
| EP3283171B1 (en) | 2015-04-15 | 2021-05-26 | Sfunga Therapeutics, Inc. | Derivatives of amphotericin b |
| CN113056274A (zh) | 2018-09-07 | 2021-06-29 | 伊利诺伊大学评议会 | 具有降低的毒性的杂化两性霉素b衍生物 |
| WO2021026450A1 (en) * | 2019-08-08 | 2021-02-11 | The Board Of Trustees Of The University Of Illinois | Hybrid amphotericin b derivatives with reduced toxicity |
| WO2021030183A1 (en) * | 2019-08-09 | 2021-02-18 | The Board Of Trustees Of The University Of Illinois | Combination treatment of systemic fungal infections |
| MX2023001649A (es) * | 2020-08-10 | 2023-04-24 | Univ Illinois | Derivados de amida hibrida de anfotericina b. |
| EP4551584A2 (en) * | 2022-07-08 | 2025-05-14 | The Board Of Trustees Of The University Of Illinois | Transfer of c2'-epimerized sugars to the amphotericin b aglycone |
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| JP2006528704A (ja) * | 2003-05-27 | 2006-12-21 | セラヴァンス インコーポレーテッド | グリコペプチド抗細菌剤と組み合わせたポリエンマクロライド抗真菌剤の使用 |
| CN101442989B (zh) * | 2004-06-21 | 2013-04-03 | 诺瓦帝斯公司 | 包括两性霉素b的组合物 |
| US8513204B2 (en) * | 2004-06-21 | 2013-08-20 | Novartis Ag | Compositions comprising amphotericin B, mehods and systems |
| WO2014059436A1 (en) * | 2012-10-12 | 2014-04-17 | The Board Of Trustees Of The University Of Illinois | Electronic tuning of site selectivity |
| WO2016061437A1 (en) * | 2014-10-17 | 2016-04-21 | The Board Of Trustees Of The University Of Illinois | Scalable synthesis of reduced toxicity derivative of amphotericin b |
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2015
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- 2015-05-15 CA CA2981288A patent/CA2981288C/en active Active
- 2015-05-15 JP JP2016567865A patent/JP6543272B2/ja active Active
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- 2015-05-15 US US15/310,815 patent/US9738677B2/en active Active
- 2015-05-15 EP EP15793421.7A patent/EP3142672B1/en active Active
- 2015-05-15 ES ES15793421T patent/ES2749927T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3142672B1 (en) | 2019-09-25 |
| JP6543272B2 (ja) | 2019-07-10 |
| EP3142672A4 (en) | 2017-11-15 |
| US9738677B2 (en) | 2017-08-22 |
| WO2015175875A1 (en) | 2015-11-19 |
| EP3142672A1 (en) | 2017-03-22 |
| DK3142672T3 (da) | 2019-10-21 |
| US20170088572A1 (en) | 2017-03-30 |
| JP2017518982A (ja) | 2017-07-13 |
| CA2981288A1 (en) | 2015-11-19 |
| ES2749927T3 (es) | 2020-03-24 |
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