CA2980478C - Compositions and methods for inhibiting kinases - Google Patents
Compositions and methods for inhibiting kinases Download PDFInfo
- Publication number
- CA2980478C CA2980478C CA2980478A CA2980478A CA2980478C CA 2980478 C CA2980478 C CA 2980478C CA 2980478 A CA2980478 A CA 2980478A CA 2980478 A CA2980478 A CA 2980478A CA 2980478 C CA2980478 C CA 2980478C
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- CA
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- compound
- virus
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- composition
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562151659P | 2015-04-23 | 2015-04-23 | |
| US62/151,659 | 2015-04-23 | ||
| US201562182955P | 2015-06-22 | 2015-06-22 | |
| US62/182,955 | 2015-06-22 | ||
| PCT/US2016/028914 WO2016172528A1 (en) | 2015-04-23 | 2016-04-22 | Compositions and methods for inhibiting kinases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2980478A1 CA2980478A1 (en) | 2016-10-27 |
| CA2980478C true CA2980478C (en) | 2024-01-23 |
Family
ID=57144281
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2980478A Active CA2980478C (en) | 2015-04-23 | 2016-04-22 | Compositions and methods for inhibiting kinases |
Country Status (6)
| Country | Link |
|---|---|
| US (8) | US9828370B2 (https=) |
| EP (1) | EP3286179A4 (https=) |
| JP (1) | JP6795518B2 (https=) |
| AU (2) | AU2016252860B2 (https=) |
| CA (1) | CA2980478C (https=) |
| WO (1) | WO2016172528A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3286179A4 (en) * | 2015-04-23 | 2018-08-29 | Inhibikase Therapeutics, Inc. | Compositions and methods for inhibiting kinases |
| US20200046699A1 (en) * | 2016-10-25 | 2020-02-13 | Inhibikase Therapeutics, Inc. | Compositions and methods for inhibiting kinases |
| US10855891B2 (en) | 2016-11-21 | 2020-12-01 | Samsung Electro-Mechanics Co., Ltd. | Apparatus for controlling position of camera module |
| US20220010382A1 (en) * | 2018-11-12 | 2022-01-13 | Blueprint Medicines Corporation | Avapritinib resistance of kit mutants |
| CN114127065A (zh) * | 2019-03-05 | 2022-03-01 | 鸿仪有限责任公司 | 用于治疗神经退行性疾病和癌症的化合物 |
| CN115175673A (zh) * | 2020-02-26 | 2022-10-11 | 上海科技大学 | 双硫仑在抗冠状病毒中的应用 |
| CA3176661A1 (en) * | 2020-04-24 | 2021-10-28 | Memorial Sloan-Kettering Cancer Center | Targeted therapy for the treatment & prevention of life-threatening complications of infection |
| CN112552283A (zh) * | 2020-12-07 | 2021-03-26 | 天津羲泽润科技有限公司 | 一种新型替尼类药物的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE454152T1 (de) * | 2003-06-13 | 2010-01-15 | Novartis Pharma Gmbh | 2-aminopyrimidin-derivate als raf-kinase-hemmer |
| US8268809B2 (en) * | 2006-09-05 | 2012-09-18 | Emory University | Kinase inhibitors for preventing or treating pathogen infection and method of use thereof |
| US8466154B2 (en) * | 2006-10-27 | 2013-06-18 | The Board Of Regents Of The University Of Texas System | Methods and compositions related to wrapping of dehydrons |
| CN102406648A (zh) | 2010-09-21 | 2012-04-11 | 中国科学院生物物理研究所 | 甲磺酸伊马替尼在制备抗帕金森病药物中的应用 |
| WO2013171642A1 (en) | 2012-05-15 | 2013-11-21 | Novartis Ag | Benzamide derivatives for inhibiting the activity of abl1, abl2 and bcr-abl1 |
| AU2013326850B2 (en) | 2012-10-04 | 2017-09-21 | Inhibikase Therapeutics, Inc. | Novel compounds, their preparation and their uses |
| EP3286179A4 (en) | 2015-04-23 | 2018-08-29 | Inhibikase Therapeutics, Inc. | Compositions and methods for inhibiting kinases |
| US20200046699A1 (en) | 2016-10-25 | 2020-02-13 | Inhibikase Therapeutics, Inc. | Compositions and methods for inhibiting kinases |
-
2016
- 2016-04-22 EP EP16783966.1A patent/EP3286179A4/en active Pending
- 2016-04-22 US US15/136,497 patent/US9828370B2/en active Active
- 2016-04-22 CA CA2980478A patent/CA2980478C/en active Active
- 2016-04-22 JP JP2017555374A patent/JP6795518B2/ja active Active
- 2016-04-22 AU AU2016252860A patent/AU2016252860B2/en active Active
- 2016-04-22 WO PCT/US2016/028914 patent/WO2016172528A1/en not_active Ceased
-
2017
- 2017-11-07 US US15/805,693 patent/US10118923B2/en active Active
-
2018
- 2018-10-24 US US16/169,677 patent/US10316031B2/en active Active
- 2018-10-24 US US16/169,683 patent/US10344027B2/en active Active
-
2019
- 2019-06-26 US US16/452,828 patent/US10906896B2/en active Active
-
2020
- 2020-12-14 AU AU2020286339A patent/AU2020286339B2/en active Active
-
2021
- 2021-01-05 US US17/141,825 patent/US11407747B2/en active Active
-
2022
- 2022-06-24 US US17/849,141 patent/US11725005B2/en active Active
-
2024
- 2024-09-24 US US18/894,338 patent/US20250250266A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US10906896B2 (en) | 2021-02-02 |
| US9828370B2 (en) | 2017-11-28 |
| AU2020286339A1 (en) | 2021-01-21 |
| US11725005B2 (en) | 2023-08-15 |
| US20210130343A1 (en) | 2021-05-06 |
| US20230159514A1 (en) | 2023-05-25 |
| WO2016172528A1 (en) | 2016-10-27 |
| US20160311816A1 (en) | 2016-10-27 |
| AU2016252860B2 (en) | 2020-09-17 |
| US20190119266A1 (en) | 2019-04-25 |
| US10316031B2 (en) | 2019-06-11 |
| US10344027B2 (en) | 2019-07-09 |
| AU2020286339B2 (en) | 2021-10-21 |
| AU2016252860A1 (en) | 2017-09-21 |
| EP3286179A4 (en) | 2018-08-29 |
| JP6795518B2 (ja) | 2020-12-02 |
| CA2980478A1 (en) | 2016-10-27 |
| US11407747B2 (en) | 2022-08-09 |
| US20190055234A1 (en) | 2019-02-21 |
| US20250250266A1 (en) | 2025-08-07 |
| JP2018513868A (ja) | 2018-05-31 |
| US20180057488A1 (en) | 2018-03-01 |
| EP3286179A1 (en) | 2018-02-28 |
| US20200031819A1 (en) | 2020-01-30 |
| US10118923B2 (en) | 2018-11-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20210421 |
|
| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 9TH ANNIV.) - STANDARD Year of fee payment: 9 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20241227 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT Effective date: 20241227 |