CA2978142C - Thermochemical-based antibody inactivation methods and systems - Google Patents

Thermochemical-based antibody inactivation methods and systems Download PDF

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Publication number
CA2978142C
CA2978142C CA2978142A CA2978142A CA2978142C CA 2978142 C CA2978142 C CA 2978142C CA 2978142 A CA2978142 A CA 2978142A CA 2978142 A CA2978142 A CA 2978142A CA 2978142 C CA2978142 C CA 2978142C
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Canada
Prior art keywords
heat source
sample
temperature
buffer
target
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CA2978142A
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English (en)
French (fr)
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CA2978142A1 (en
Inventor
Antony HUBBARD
Tobin Jones
Lei Tang
Wenjun Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ventana Medical Systems Inc
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Ventana Medical Systems Inc
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Publication date
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Publication of CA2978142A1 publication Critical patent/CA2978142A1/en
Application granted granted Critical
Publication of CA2978142C publication Critical patent/CA2978142C/en
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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G01N1/312—Apparatus therefor for samples mounted on planar substrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2474/00—Immunochemical assays or immunoassays characterised by detection mode or means of detection
    • G01N2474/20—Immunohistochemistry assay

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA2978142A 2015-04-13 2016-04-12 Thermochemical-based antibody inactivation methods and systems Active CA2978142C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562146610P 2015-04-13 2015-04-13
US62/146,610 2015-04-13
US201562260147P 2015-11-25 2015-11-25
US62/260,147 2015-11-25
PCT/EP2016/057955 WO2016166073A1 (en) 2015-04-13 2016-04-12 Thermochemical-based antibody inactivation methods and systems

Publications (2)

Publication Number Publication Date
CA2978142A1 CA2978142A1 (en) 2016-10-20
CA2978142C true CA2978142C (en) 2023-08-08

Family

ID=55745776

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2978142A Active CA2978142C (en) 2015-04-13 2016-04-12 Thermochemical-based antibody inactivation methods and systems

Country Status (8)

Country Link
US (1) US20180095082A1 (https=)
EP (1) EP3283881B1 (https=)
JP (1) JP6811721B2 (https=)
AU (1) AU2016248882B2 (https=)
CA (1) CA2978142C (https=)
DK (1) DK3283881T3 (https=)
ES (1) ES2939352T3 (https=)
WO (1) WO2016166073A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7262922B2 (ja) * 2017-12-06 2023-04-24 キヤノンメディカルシステムズ株式会社 タンパク質をイメージングする方法
JP7178606B2 (ja) * 2018-06-22 2022-11-28 学校法人麻布獣医学園 染色された生物組織の脱色法
WO2020033756A1 (en) * 2018-08-09 2020-02-13 F. Hoffmann-La Roche Ag Determination of parkinson's disease

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2354598T3 (es) * 1998-02-27 2011-03-16 Ventana Medical Systems, Inc. Aparato de patología molecular automatizado que tiene calefactores de portaobjetos independientes.
WO2008063378A2 (en) 2006-11-01 2008-05-29 Ventana Medical Systems, Inc. Haptens, hapten conjugates, compositions thereof and method for their preparation and use
WO2009117139A2 (en) * 2008-03-21 2009-09-24 Spring Bioscience Corporation Dual method for performing in situ hybridization

Also Published As

Publication number Publication date
AU2016248882A1 (en) 2017-09-14
JP2018514766A (ja) 2018-06-07
AU2016248882B2 (en) 2020-04-30
WO2016166073A1 (en) 2016-10-20
JP6811721B2 (ja) 2021-01-13
DK3283881T3 (da) 2023-02-27
EP3283881B1 (en) 2022-12-14
US20180095082A1 (en) 2018-04-05
ES2939352T3 (es) 2023-04-21
CA2978142A1 (en) 2016-10-20
EP3283881A1 (en) 2018-02-21

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