CA2964625C - Fatty liver disease treatment using glucocorticoid and mineralocorticoid receptor antagonists - Google Patents
Fatty liver disease treatment using glucocorticoid and mineralocorticoid receptor antagonists Download PDFInfo
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- CA2964625C CA2964625C CA2964625A CA2964625A CA2964625C CA 2964625 C CA2964625 C CA 2964625C CA 2964625 A CA2964625 A CA 2964625A CA 2964625 A CA2964625 A CA 2964625A CA 2964625 C CA2964625 C CA 2964625C
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US201462064358P | 2014-10-15 | 2014-10-15 | |
| US62/064,358 | 2014-10-15 | ||
| US201462092041P | 2014-12-15 | 2014-12-15 | |
| US62/092,041 | 2014-12-15 | ||
| PCT/US2015/055487 WO2016061195A1 (en) | 2014-10-15 | 2015-10-14 | Fatty liver disease treatment using glucocorticoid and mineralocorticoid receptor antagonists |
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| CA2964625A1 CA2964625A1 (en) | 2016-04-21 |
| CA2964625C true CA2964625C (en) | 2023-03-07 |
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| CA2964625A Active CA2964625C (en) | 2014-10-15 | 2015-10-14 | Fatty liver disease treatment using glucocorticoid and mineralocorticoid receptor antagonists |
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| BR (1) | BR112017007860B1 (OSRAM) |
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| DK (1) | DK3206692T3 (OSRAM) |
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| NZ (1) | NZ731060A (OSRAM) |
| PH (1) | PH12017500710B1 (OSRAM) |
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| PT (1) | PT3206692T (OSRAM) |
| RU (1) | RU2718921C2 (OSRAM) |
| SG (1) | SG11201703024VA (OSRAM) |
| UA (1) | UA123537C2 (OSRAM) |
| WO (1) | WO2016061195A1 (OSRAM) |
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| PT3206692T (pt) | 2014-10-15 | 2024-04-30 | Corcept Therapeutics Inc | Tratamento da doença hepática gordurosa utilizando antagonistas dos recetores de glicocorticoides e mineralocorticoides |
| JP7196201B2 (ja) * | 2018-06-04 | 2022-12-26 | コーセプト セラピューティクス， インコーポレイテッド | ピリミジンシクロヘキセニル糖質コルチコイドレセプター調節因子 |
| KR20210153056A (ko) | 2019-03-18 | 2021-12-16 | 리네트 케이. 니만 | 인슐린 감수성 개선 방법 |
| AU2021266739B2 (en) * | 2020-05-06 | 2024-11-28 | Corcept Therapeutics Incorporated | Formulations of pyrimidine cyclohexyl glucocorticoid receptor modulators |
| CA3182272A1 (en) | 2020-05-06 | 2021-11-11 | Corcept Therapeutics Incorporated | Polymorphs of pyrimidine cyclohexyl glucocorticoid receptor modulators |
| KR102481705B1 (ko) * | 2020-08-04 | 2022-12-27 | 연세대학교 산학협력단 | 트리아졸 유도체를 유효성분으로 포함하는 간 섬유증의 예방 또는 치료용 조성물 |
| KR20230124020A (ko) | 2020-12-21 | 2023-08-24 | 코어셉트 쎄라퓨틱스 인코포레이티드 | 피리미딘 시클로헥실 글루코코르티코이드 수용체 조절제의제조 방법 |
| AU2022271209A1 (en) * | 2021-05-05 | 2023-11-09 | Corcept Therapeutics Incorporated | Methods for reducing liver fat and for treating fatty liver disorders |
| WO2025174745A1 (en) * | 2024-02-12 | 2025-08-21 | Corcept Therapeutics Incorporated | MIRICORILANT TREATMENT FOR FATTY LIVER DISEASES and its EFFECTS on LIVER FAT CONTENT, FATTY ACIDS, ACYLGLYCEROLS, and SECONDARY BILE ACIDS |
| WO2025255357A1 (en) * | 2024-06-06 | 2025-12-11 | Corcept Therapeutics Incorporated | Methods for preparing and maintaining livers and portions thereof for liver transplantation |
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| GB0213745D0 (en) * | 2002-06-14 | 2002-07-24 | Univ Edinburgh | Enzyme |
| EP1534273A4 (en) | 2002-07-18 | 2007-08-22 | Bristol Myers Squibb Co | MODULATORS OF THE GLUCOCORTICOID RECEPTOR AND METHOD |
| US7745657B2 (en) | 2005-05-18 | 2010-06-29 | Merck Sharp & Dohme Corp. | D-homoandrosta-17-yl carbamate derivatives as selective glucocorticoid receptor ligands |
| WO2007022518A2 (en) | 2005-08-19 | 2007-02-22 | Amylin Pharmaceuticals, Inc. | New uses of glucoregulatory proteins |
| EP1941040A1 (en) * | 2005-09-19 | 2008-07-09 | Johnson & Johnson Pharmaceutical Research & Development L.L.C. | Modulation of glucocorticoid receptor expression |
| GB0601092D0 (en) * | 2006-01-19 | 2006-03-01 | Daniolabs Ltd | The Prevention Of Systemic Side-Effects Of Glucocorticoids |
| ES2546181T3 (es) | 2006-05-09 | 2015-09-21 | Genzyme Corporation | Métodos de tratar la enfermedad del hígado graso mediante inhibición de la síntesis de glucoesfingolípidos |
| US9623021B2 (en) | 2007-01-22 | 2017-04-18 | Gtx, Inc. | Nuclear receptor binding agents |
| MX2009011062A (es) | 2007-04-13 | 2009-10-29 | Schering Corp | Derivados de pirimidindiona y sus metodos de uso. |
| US8003689B2 (en) | 2008-06-20 | 2011-08-23 | Gtx, Inc. | Metabolites of selective androgen receptor modulators and methods of use thereof |
| AU2010232670B2 (en) | 2009-04-03 | 2015-07-09 | F. Hoffmann-La Roche Ag | Propane- I-sulfonic acid {3- [5- (4 -chloro-phenyl) -1H-pyrrolo [2, 3-b] pyridine-3-carbonyl] -2, 4-difluoro-pheny l } -amide compositions and uses thereof |
| JP6039587B2 (ja) | 2011-03-18 | 2016-12-07 | コーセプト セラピューティクス， インコーポレイテッド | ピリミジンシクロヘキシルグルココルチコイドレセプター調節因子 |
| PT3206692T (pt) | 2014-10-15 | 2024-04-30 | Corcept Therapeutics Inc | Tratamento da doença hepática gordurosa utilizando antagonistas dos recetores de glicocorticoides e mineralocorticoides |
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2015
- 2015-10-14 PT PT158512384T patent/PT3206692T/pt unknown
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- 2015-10-14 DK DK15851238.4T patent/DK3206692T3/da active
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- 2015-10-14 WO PCT/US2015/055487 patent/WO2016061195A1/en not_active Ceased
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- 2015-10-14 UA UAA201704069A patent/UA123537C2/uk unknown
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- 2015-10-14 EP EP24157529.9A patent/EP4353310A3/en active Pending
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2017
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- 2017-04-21 ZA ZA2017/02813A patent/ZA201702813B/en unknown
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2019
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2020
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2023
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2025
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