CA2956658C - Composition comprenant des solutions de polyglucosamine-glyoxylate melangees avec de l'hyaluronane - Google Patents

Composition comprenant des solutions de polyglucosamine-glyoxylate melangees avec de l'hyaluronane Download PDF

Info

Publication number
CA2956658C
CA2956658C CA2956658A CA2956658A CA2956658C CA 2956658 C CA2956658 C CA 2956658C CA 2956658 A CA2956658 A CA 2956658A CA 2956658 A CA2956658 A CA 2956658A CA 2956658 C CA2956658 C CA 2956658C
Authority
CA
Canada
Prior art keywords
composition
chitosan
polyglucosamine
glyoxylate
hyaluronan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2956658A
Other languages
English (en)
Other versions
CA2956658A1 (fr
Inventor
Amine Selmani
Abdellatif Chenite
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oligo Medic Inc
Original Assignee
Oligo Medic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oligo Medic Inc filed Critical Oligo Medic Inc
Publication of CA2956658A1 publication Critical patent/CA2956658A1/fr
Application granted granted Critical
Publication of CA2956658C publication Critical patent/CA2956658C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/02—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group

Abstract

La présente invention porte sur un procédé qui permet la formation directe de solution de type gel de polyglucosamine à un pH neutre de 7 à 8, supprimant la nécessité d'une dissolution préalable de polyglucosamine en milieu acide, et sur une association liquide homogène de polyglucosamine-glyoxylate dans de l'hyaluronane. L'invention porte également sur l'utilisation de ces solutions dans le traitement d'affections articulaires telles que l'arthrose.
CA2956658A 2013-07-30 2014-07-29 Composition comprenant des solutions de polyglucosamine-glyoxylate melangees avec de l'hyaluronane Active CA2956658C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361859921P 2013-07-30 2013-07-30
US61/859,921 2013-07-30
PCT/CA2014/050713 WO2015013821A1 (fr) 2013-07-30 2014-07-29 Composition comprenant des solutions de polyglucosamine-glyoxylate mélangées avec de l'hyaluronane

Publications (2)

Publication Number Publication Date
CA2956658A1 CA2956658A1 (fr) 2015-02-05
CA2956658C true CA2956658C (fr) 2021-03-02

Family

ID=52430790

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2956658A Active CA2956658C (fr) 2013-07-30 2014-07-29 Composition comprenant des solutions de polyglucosamine-glyoxylate melangees avec de l'hyaluronane

Country Status (2)

Country Link
CA (1) CA2956658C (fr)
WO (1) WO2015013821A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITUA20164153A1 (it) * 2016-06-07 2017-12-07 Jointherapeutics S R L Composizioni polisaccaridiche impiegabili nella riparazione tissutale
WO2022226633A1 (fr) * 2021-04-30 2022-11-03 Oligo Médic Inc. Nouvelles compositions solubles dans l'eau de chitosane et procédé pour leur préparation

Also Published As

Publication number Publication date
WO2015013821A1 (fr) 2015-02-05
CA2956658A1 (fr) 2015-02-05

Similar Documents

Publication Publication Date Title
JP7368940B2 (ja) ｉｎ ｓｉｔｕ架橋性多糖類組成物及びその使用
US8784850B2 (en) Highly biocompatible dual thermogelling chitosan/glucosamine salt composition
CA2672495C (fr) Nouveaux melanges injectables de chitosans formant des hydrogels
JP5746617B2 (ja) キトサン混合物を形成する注入可能なヒドロゲル
US20070254016A1 (en) Biodegradable foam
TWI683674B (zh) 具有改良抗性之多糖軟組織充填劑
SG183379A1 (en) An intra-articular supplementation method for treating joint diseases and injuries
US20210308332A1 (en) Hydrogel compositions encapsulating solid particles
JP2011037849A (ja) 消化性潰瘍及び十二指腸潰瘍の治療及び予防に使用されるヒアルロン酸混合物
CA2808872C (fr) Compositions de sel de chitosane/glucosamine doubles gelifiant sous l'effet de la chaleur et hautement biocompatibles
CA2956658C (fr) Composition comprenant des solutions de polyglucosamine-glyoxylate melangees avec de l'hyaluronane
US10857176B2 (en) Composition comprising polyglucosamine-glyoxylate solutions mixed with hyaluronan
Fakhari Biomedical application of hyaluronic acid nanoparticles
KR102580370B1 (ko) 생체적합성 천연고분자 및 dna 단편 혼합물을 함유하는 유착방지제 및 이의 제조 방법
JP2024518575A (ja) ポリマー組成物およびその製造方法
KR20220155555A (ko) 폴리머 조성물 및 이의 제조방법
CN116687835A (zh) 一种可关节腔注射的长效缓释凝胶及其制备方法
KR20210120998A (ko) 아미드 가교결합된 하이드로겔의 가교결합-후 부분 분해

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20190729