CA2953476A1 - Procede de detection et de quantification de la fibrose - Google Patents
Procede de detection et de quantification de la fibrose Download PDFInfo
- Publication number
- CA2953476A1 CA2953476A1 CA2953476A CA2953476A CA2953476A1 CA 2953476 A1 CA2953476 A1 CA 2953476A1 CA 2953476 A CA2953476 A CA 2953476A CA 2953476 A CA2953476 A CA 2953476A CA 2953476 A1 CA2953476 A1 CA 2953476A1
- Authority
- CA
- Canada
- Prior art keywords
- spectral
- fibrosis
- sample
- collagen
- infrared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 206010016654 Fibrosis Diseases 0.000 title claims abstract description 50
- 230000004761 fibrosis Effects 0.000 title claims abstract description 48
- 238000000034 method Methods 0.000 title claims abstract description 31
- 230000003595 spectral effect Effects 0.000 claims abstract description 41
- 102000008186 Collagen Human genes 0.000 claims abstract description 31
- 108010035532 Collagen Proteins 0.000 claims abstract description 31
- 229920001436 collagen Polymers 0.000 claims abstract description 31
- 238000012545 processing Methods 0.000 claims abstract description 23
- 238000001228 spectrum Methods 0.000 claims abstract description 17
- 238000002329 infrared spectrum Methods 0.000 claims abstract description 10
- 230000001575 pathological effect Effects 0.000 claims abstract description 9
- 239000012188 paraffin wax Substances 0.000 claims description 8
- 238000004566 IR spectroscopy Methods 0.000 claims description 7
- 230000009466 transformation Effects 0.000 claims description 6
- 206010061218 Inflammation Diseases 0.000 claims description 4
- 230000004054 inflammatory process Effects 0.000 claims description 4
- 238000005033 Fourier transform infrared spectroscopy Methods 0.000 claims description 3
- 230000008030 elimination Effects 0.000 claims description 3
- 238000003379 elimination reaction Methods 0.000 claims description 3
- 238000006386 neutralization reaction Methods 0.000 claims description 3
- 238000007781 pre-processing Methods 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 description 29
- 238000011002 quantification Methods 0.000 description 16
- 210000002808 connective tissue Anatomy 0.000 description 10
- 238000001574 biopsy Methods 0.000 description 9
- 238000001514 detection method Methods 0.000 description 9
- 210000000056 organ Anatomy 0.000 description 6
- 102000012422 Collagen Type I Human genes 0.000 description 5
- 108010022452 Collagen Type I Proteins 0.000 description 5
- 238000009825 accumulation Methods 0.000 description 5
- 239000003086 colorant Substances 0.000 description 4
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 208000019425 cirrhosis of liver Diseases 0.000 description 3
- 230000005284 excitation Effects 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 238000004040 coloring Methods 0.000 description 2
- 230000018044 dehydration Effects 0.000 description 2
- 238000006297 dehydration reaction Methods 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 230000002440 hepatic effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000007170 pathology Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 208000005069 pulmonary fibrosis Diseases 0.000 description 2
- 201000002793 renal fibrosis Diseases 0.000 description 2
- 210000005084 renal tissue Anatomy 0.000 description 2
- 230000011218 segmentation Effects 0.000 description 2
- 238000010200 validation analysis Methods 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 206010019668 Hepatic fibrosis Diseases 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 238000001069 Raman spectroscopy Methods 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 description 1
- 229910001634 calcium fluoride Inorganic materials 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000007882 cirrhosis Effects 0.000 description 1
- 229940096422 collagen type i Drugs 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 230000003176 fibrotic effect Effects 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000005470 impregnation Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000011862 kidney biopsy Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000005229 liver cell Anatomy 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000005300 metallic glass Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- SBIBMFFZSBJNJF-UHFFFAOYSA-N selenium;zinc Chemical compound [Se]=[Zn] SBIBMFFZSBJNJF-UHFFFAOYSA-N 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000004781 supercooling Methods 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/3563—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing solids; Preparation of samples therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N2021/3196—Correlating located peaks in spectrum with reference data, e.g. fingerprint data
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N2021/3595—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using FTIR
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/10—Scanning
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/12—Circuits of general importance; Signal processing
- G01N2201/129—Using chemometrical methods
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Physiology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1457323 | 2014-07-29 | ||
| FR1457323A FR3024546B1 (fr) | 2014-07-29 | 2014-07-29 | Procede de detection et de quantification de la fibrose |
| PCT/FR2015/051826 WO2016016531A1 (fr) | 2014-07-29 | 2015-07-02 | Procédé de détection et de quantification de la fibrose |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2953476A1 true CA2953476A1 (fr) | 2016-02-04 |
Family
ID=51787091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2953476A Abandoned CA2953476A1 (fr) | 2014-07-29 | 2015-07-02 | Procede de detection et de quantification de la fibrose |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9810625B2 (enExample) |
| EP (1) | EP3175224B1 (enExample) |
| JP (1) | JP6246978B2 (enExample) |
| CA (1) | CA2953476A1 (enExample) |
| FR (1) | FR3024546B1 (enExample) |
| WO (1) | WO2016016531A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10641659B2 (en) * | 2018-08-14 | 2020-05-05 | Shimadzu Corporation | Infrared microscope with adjustable connection optical system |
| CN110208508A (zh) * | 2019-06-18 | 2019-09-06 | 余碧芝 | 判定胶原蛋白肽品质优劣的方法 |
| JP7572063B2 (ja) * | 2019-08-26 | 2024-10-23 | 国立研究開発法人科学技術振興機構 | 線維化測定装置、線維化測定方法および特性測定装置 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6146897A (en) * | 1995-11-13 | 2000-11-14 | Bio-Rad Laboratories | Method for the detection of cellular abnormalities using Fourier transform infrared spectroscopy |
| US7277744B2 (en) * | 1999-03-22 | 2007-10-02 | Schaefer Allan L | Early detection of inflammation and infection using infrared thermography |
| US6841388B2 (en) * | 2000-12-05 | 2005-01-11 | Vysis, Inc. | Method and system for diagnosing pathology in biological samples by detection of infrared spectral markers |
| JP4588324B2 (ja) * | 2002-04-05 | 2010-12-01 | マサチユセツツ・インスチチユート・オブ・テクノロジイ | 組織測定用プローブ |
| WO2005042760A2 (en) * | 2003-09-29 | 2005-05-12 | Pathwork Informatics, Inc. | Systems and methods for detecting biological features |
| JP5372137B2 (ja) * | 2009-03-13 | 2013-12-18 | 京都府公立大学法人 | ラマン散乱を用いた生体組織イメージング |
| EP2302359A1 (en) * | 2009-09-24 | 2011-03-30 | Université De Reims Champagne-Ardenne | Serum infrared spectroscopy for non invasive assessment of hepatic fibrosis in patients with chronic liver disease |
| EP4321889A3 (en) * | 2012-03-19 | 2024-03-20 | Genetic Innovations Inc. | Devices, systems, and methods for virtual staining |
| WO2015010102A1 (en) * | 2013-07-18 | 2015-01-22 | Baylor College Of Medicine | Methods and compositions for treatment of fibrosis |
-
2014
- 2014-07-29 FR FR1457323A patent/FR3024546B1/fr not_active Expired - Fee Related
-
2015
- 2015-07-02 CA CA2953476A patent/CA2953476A1/fr not_active Abandoned
- 2015-07-02 WO PCT/FR2015/051826 patent/WO2016016531A1/fr not_active Ceased
- 2015-07-02 JP JP2017505226A patent/JP6246978B2/ja not_active Expired - Fee Related
- 2015-07-02 EP EP15756961.7A patent/EP3175224B1/fr not_active Not-in-force
- 2015-07-02 US US15/329,011 patent/US9810625B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP6246978B2 (ja) | 2017-12-13 |
| WO2016016531A1 (fr) | 2016-02-04 |
| EP3175224B1 (fr) | 2018-03-14 |
| US20170212041A1 (en) | 2017-07-27 |
| FR3024546A1 (fr) | 2016-02-05 |
| JP2017523423A (ja) | 2017-08-17 |
| EP3175224A1 (fr) | 2017-06-07 |
| US9810625B2 (en) | 2017-11-07 |
| FR3024546B1 (fr) | 2018-08-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20170818 |
|
| FZDE | Dead |
Effective date: 20200304 |