CA2943659C - Pyridyl piperidines - Google Patents
Pyridyl piperidines Download PDFInfo
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- CA2943659C CA2943659C CA2943659A CA2943659A CA2943659C CA 2943659 C CA2943659 C CA 2943659C CA 2943659 A CA2943659 A CA 2943659A CA 2943659 A CA2943659 A CA 2943659A CA 2943659 C CA2943659 C CA 2943659C
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- spiro
- cancer
- pyrazol
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- diaza
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- -1 Pyridyl piperidines Chemical class 0.000 title claims abstract description 172
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- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 10
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14001145.3 | 2014-03-27 | ||
| EP14001145 | 2014-03-27 | ||
| PCT/EP2015/000528 WO2015144290A1 (en) | 2014-03-27 | 2015-03-10 | Pyridyl piperidines |
Publications (2)
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| CA2943659A1 CA2943659A1 (en) | 2015-10-01 |
| CA2943659C true CA2943659C (en) | 2023-04-25 |
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| CA2943659A Active CA2943659C (en) | 2014-03-27 | 2015-03-10 | Pyridyl piperidines |
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| JP (1) | JP6434989B2 (enExample) |
| CN (1) | CN106458992B (enExample) |
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| CA (1) | CA2943659C (enExample) |
| ES (1) | ES2720324T3 (enExample) |
| IL (1) | IL247728B (enExample) |
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| JP6447304B2 (ja) * | 2015-03-27 | 2019-01-09 | Jsr株式会社 | 液晶配向剤、液晶配向膜及びその製造方法、液晶表示素子、位相差フィルム及びその製造方法、重合体並びに化合物 |
| MX2017015456A (es) | 2015-06-01 | 2018-11-29 | Bantam Pharmaceutical Llc | Compuestos de pirazol y pirrol sustituidos y metodos para su uso por inhibición de iniciación de traducción y tratamiento de enfermedades y trastornos relacionados con ellos. |
| MX390651B (es) * | 2015-11-03 | 2025-03-21 | Apriligen Inc | Compuestos para el tratamiento de trastornos hipoproliferativos |
| CN110769823A (zh) | 2016-11-30 | 2020-02-07 | 班塔姆制药有限责任公司 | 使用被取代的吡唑和吡咯化合物以及治疗过度增生性疾病的方法 |
| AU2017366901B2 (en) * | 2016-11-30 | 2022-09-29 | Bantam Pharmaceutical, Llc | Substituted pyrazole compounds and methods of using them for treatment of hyperproliferative diseases |
| EP3575297B1 (en) | 2017-01-30 | 2024-12-18 | Kyoto University | Novel compound, and method for producing regulatory t cells |
| CN111163775B (zh) | 2017-10-02 | 2023-07-11 | 勃林格殷格翰国际有限公司 | 作为cdk8/cdk19抑制剂的新型[1,6]萘啶化合物和衍生物 |
| WO2021126725A1 (en) * | 2019-12-17 | 2021-06-24 | Merck Sharp & Dohme Corp. | Novel substituted 1,3,8-triazaspiro[4,5]decane-2,4-dione compounds as indoleamine 2,3-dioxygenase (ido) and/or tryptophan 2,3-dioxygenase (tdo) inhibitors |
| AR127141A1 (es) | 2021-09-27 | 2023-12-20 | Univ Kyoto | Método para producir células t |
| CN118591379A (zh) | 2021-11-24 | 2024-09-03 | 雷格细胞股份有限公司 | 用于治疗或预防t细胞相关疾病的药物组合物 |
| KR20240116751A (ko) | 2021-11-24 | 2024-07-30 | 레그셀 가부시키가이샤 | 사람 유도성 제어성 t세포 및 그 제작 방법 |
| TW202345878A (zh) | 2022-03-23 | 2023-12-01 | 國立大學法人京都大學 | 控制性ｔ細胞之製造方法 |
| AU2023353929A1 (en) | 2022-09-26 | 2025-05-01 | Kyoto University | T cell production method |
| JPWO2024071039A1 (enExample) | 2022-09-26 | 2024-04-04 | ||
| TW202448492A (zh) | 2023-02-08 | 2024-12-16 | 日商雷格細胞股份有限公司 | 用於治療或預防天皰瘡的藥物組合物 |
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| GB0818241D0 (en) * | 2008-10-06 | 2008-11-12 | Cancer Res Technology | Compounds and their use |
| WO2012062901A2 (en) * | 2010-11-12 | 2012-05-18 | Deutsches Krebsforschungszentrum (Dkfz) | Chromene derivatives and their analoga as wnt pathway antagonists |
| PH12017500997A1 (en) * | 2012-04-04 | 2018-02-19 | Samumed Llc | Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof |
| JP6209593B2 (ja) * | 2012-05-04 | 2017-10-04 | サミュメッド リミテッド ライアビリティ カンパニー | １Ｈ−ピラゾロ［３，４−ｂ］ピリジンおよびそれらの治療的使用 |
| JP6317360B2 (ja) * | 2012-10-08 | 2018-04-25 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | ２−アミノピリジン化合物 |
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2015
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- 2015-03-10 EP EP15709097.8A patent/EP3122739B1/en not_active Not-in-force
- 2015-03-10 JP JP2016559366A patent/JP6434989B2/ja not_active Expired - Fee Related
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| WO2015144290A8 (en) | 2015-12-23 |
| IL247728B (en) | 2019-12-31 |
| EP3122739A1 (en) | 2017-02-01 |
| JP2017510590A (ja) | 2017-04-13 |
| CN106458992A (zh) | 2017-02-22 |
| AU2015236855B2 (en) | 2018-11-01 |
| WO2015144290A1 (en) | 2015-10-01 |
| JP6434989B2 (ja) | 2018-12-05 |
| US20170107222A1 (en) | 2017-04-20 |
| CA2943659A1 (en) | 2015-10-01 |
| EP3122739B1 (en) | 2019-01-16 |
| US9926319B2 (en) | 2018-03-27 |
| AU2015236855A1 (en) | 2016-11-10 |
| CN106458992B (zh) | 2019-03-15 |
| IL247728A0 (en) | 2016-11-30 |
| ES2720324T3 (es) | 2019-07-19 |
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